New Mexico Cancer Center

Pediatric and Adolescent Cancers Among American Indian and Alaska Native Peoples

OBJECTIVES To understand the burden of cancer in American Indian and Alaska Native (AIAN) children (0–14 y) and adolescents (15–19 y), and determine relative burden of cancer compared with other racial and ethnic groups. METHODS We used the Surveillance, Epidemiology, and End Res...

Association between index adenomas and advanced neoplasia at third surveillance colonoscopy: Data from the New Hampshire Colonoscopy Registry

Background: Due to a lack of data, the USMTSF does not provide guidance for the 3 rd surveillance exam for adenomas detected on index colonoscopy. Our aim was to assess advanced outcome risk at 3 rd surveillance in patients with index adenomas. Methods: We included patients from...

End processing in NHEJ by Polymerase λ and PNKP is coordinated during short-range synapsis

Non-homologous end joining (NHEJ) is a major pathway of DNA double strand break (DSB) repair, capable of directly joining both damaged strands of DNA through the coordinated activities of repair factors that detect the termini, physically bridge them together, and perform the che...

Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα

Eukaryotic genomic DNA is packaged into chromatin through a fundamental repeating unit known as the nucleosome core particle. Within this chromatin context, genomic DNA is constantly exposed to endogenous and exogenous stress that result in the formation of DNA damage, which must...