New Generation University College

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Establishment and tenogenic characterization of canine tendon-derived stem cells compared with adipose-derived stem cells

Abstract Background Tendon-derived stem cells (TDSCs) possess inherent lineage specificity for tendon regeneration. However, their characteristics in dogs remain poorly defined. Establishing a canine tendon-derived stem cell (cTDSC) population and verifying its tenogenic properti...

Combined Ramp Lesion and Lateral Meniscus Root Tear Increase Rotational and Translational Instability in an Anterior Cruciate Ligament‐Deficient Knee: A Cadaveric Study

Purpose To evaluate knee instability associated with combined ramp lesion and lateral meniscus posterior root tear (LMRT) in an anterior cruciate ligament (ACL)‐deficient knee (the new terrible triad). Methods Ten cadaveric knees were tested biomechanically. Internal rotation (IR...

False-positive patterns in optical coherence tomography in hyperopic and myopic eyes

Background/aims This study aimed to evaluate how axial length influences false-positive rates in ganglion cell analysis (GCA) and retinal nerve fibre layer (RNFL) maps and to identify distinct false-positive patterns on optical coherence tomography (OCT) deviation maps across axi...

COBRA: Cell-type-specific Orthogonal Batch effect Removal Algorithm in single cell RNA-sequencing data

Abstract Motivation Single-cell RNA sequencing (scRNA-seq) enables high-resolution profiling of cellular heterogeneity, yet batch effects remain a critical challenge in data integration. Existing batch correction methods often assume homogeneous batch effect across cell types, op...

Perceived training needs and barriers among Korean residents: a cross-sectional survey for competency-based education

PURPOSE: Current South Korean resident education relies heavily on apprenticeship models rather than the systematic curricula needed for multifaceted competency development. Therefore, a rigorous needs assessment is required for effective program design, particularly to target ye...

Mutation-agnostic base editing of the progerin farnesylation site rescues Hutchinson-Gilford progeria syndrome phenotypes in neuromuscular organoids

Abstract Hutchinson Gilford progeria syndrome (HGPS) is a fatal premature aging disorder caused by pathogenic farnesylated lamin A variants that disrupt nuclear architecture and DNA repair. Current therapies, including farnesyltransferase inhibitors, provide only modest survival...

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

WHO CNS5 mandates integrated histo-molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low- and lower-middle-income countries (LICs/LMICs), limiting implementation of molecularly in...

Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population

OBJECTIVE: This study was undertaken to assess long-term efficacy, safety, and tolerability of adjunctive cenobamate in an open-label extension (OLE) of a randomized, double-blind, placebo-controlled, dose-response study (NCT04557085; YKP3089C035 [Study C035]) in Asian patients w...

Assessment of urban green space in Suwon special city: focusing on everyday nature spaces in neighborhood level

Abstract Urban green spaces are essential resources directly linked to citizens’ quality of life, providing a wide range of ecosystem services. However, existing policies and research have primarily focused on quantitative indicators such as area, while overlooking the qualitativ...

Ultra-processed food intake, genetic polymorphisms, and the risk of obesity in a pooled analysis of three prospective cohorts

Obesity is a major risk factor for non-communicable diseases and mortality. This study aimed to examine the associations between ultra-processed food intake and the risks of obesity and weight gain, and to evaluate whether these associations differed by polygenic scores for obesi...

Patterns of failure after primary treatment and prognostic factors in stage I, grade 2-3 endometrial cancer

Purpose: This study aimed to characterize recurrence patterns and identify prognostic factors in patients with stage I, grade 2-3 endometrioid endometrial cancer. Materials and Methods: We retrospectively analyzed 298 patients with 2009 International Federation of Gynecology and...

LDL-C–stratified residual lipoprotein(a) and inflammatory risk after acute myocardial infarction among patients with prior statin use

Abstract Background Patients can experience acute myocardial infarction (AMI) despite documented prior statin exposure, indicating persistent residual cardiovascular risk. The prognostic relevance of lipoprotein(a) [Lp(a)] and residual inflammation in this setting remains unclear...

Impact of Concomitant Grade I Degenerative Spondylolisthesis on Clinical and Radiographic Outcomes Following Biportal Endoscopic versus Microscopic Laminectomy for Lumbar Spinal Stenosis: A Post Hoc Analysis of a Multicenter Randomized Clinical Trial

Study DesignPost hoc analysis.ObjectiveTo determine whether Meyerding grade I degenerative spondylolisthesis (DS1) modifies 12-month clinical or radiographic outcomes after biportal endoscopic laminectomy (BE-L) versus microscopic laminectomy (M-L) for lumbar spinal stenosis, and...

Perioperative outcomes of robot-assisted, laparoscopic or thoracoscopic, and open surgery across 13 cancer operations: a single-institution cohort of 36,208 cases

Abstract To compare perioperative outcomes of robot-assisted surgery, video-assisted (laparoscopic or thoracoscopic) surgery and open surgery across 13 oncologic procedure groups, because aggregate technology-level comparison is confounded by procedure mix and by the calendar tim...

The Effect of Central Sensitization on Long‐Term Prognosis and Comorbidity Levels in Temporomandibular Disorders: A Prospective Longitudinal Study

ABSTRACT Background Temporomandibular disorders (TMD) have the potential to progress to a chronic form associated with various comorbidities. Prolonged symptoms may lead to central sensitization (CS), resulting in decreased treatment response and highlighting the need for persona...

Effect of visual stimulation on quantitative light-touch assessment using the active von Frey filament test

Quantitative assessment of light-touch sensation is essential in the evaluation of peripheral nerve disorders. Although the active von Frey filament test (AvF) provides objective and continuous tactile threshold measurements, the influence of testing conditions on AvF values rema...

Maternal diabetes and childhood cancer risks in offspring: a nationwide cohort study

Maternal diabetes is associated with several adverse childhood outcomes, but its link to childhood cancer remains inconclusive. We investigated this in a nationwide birth cohort using the Korean National Health Insurance database. We analyzed women who delivered singletons betwee...

A sacrificial HfN interlayer enables oxygen-buffered Mo electrodes for sub‑0.4nm equivalent oxide thickness of HfO2/ZrO2 nanolaminates for DRAM capacitors

Continued scaling of dynamic random-access memory (DRAM) capacitors demands simultaneous achievement of high capacitance density and extremely low leakage current at ever-decreasing physical thickness, making interfacial chemistry and defect control as critical as the choice of h...