National University Health System

Perioperative Hospital‐at‐Home Program: A Scoping Review

BACKGROUND: Hospital-at-Home (HaH) is an established model of care for medical patients, particularly following rapid expansion during the COVID-19 pandemic. In contrast, perioperative HaH remains in its early stages, with limited understanding of appropriate care delivery models...

Does EQ-5D measure the most relevant aspects of health across cultures? Findings from a multi-country qualitative and card-sorting study

The EQ-5D is a widely used measure of health-related quality of life (HRQoL) in health services and economic evaluations globally. However, its cross-cultural content validity remains underexplored. This study assesses the relevance and adequacy of EQ-5D across diverse cultural c...

Technical Note - A patient-specific implant for orbital wall reconstruction with infraorbital rim extension: Accuracy and proof-of-principle evaluation of an “one-fit-only” design

Accurate intraoperative positioning of patient-specific implants (PSI) in orbital wall reconstruction remains challenging due to residual translational and rotational freedom. The aim of this proof-of-principle study was to introduce an orbital PSI design refinement incorporating...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Exploring treatment burden and self-management experiences among adults receiving haemodialysis to inform person-centred digital care: a descriptive qualitative study

Person-centred care identifies the need to understand what matters to an individual, as opposed to what is the matter with them. Although digital technologies are increasingly used to support haemodialysis self-management, little is known about how the experiences of those receiv...

Transportability of Prognostic Markers

Transportability, the ability to maintain performance across populations, is a desirable property of markers of clinical outcomes. However, empirical findings indicate that markers often exhibit varying performances across populations. For prognostic markers that are advertised a...

Formal and informal science-policy interaction during public health emergencies of international concern: a scoping review

Abstract Background Interaction between science and policy might be a crucial asset for policy decisions during public health emergencies. Much work has been published about processes and forms of science-policy interaction on the one hand and challenges of public health emergenc...

Sleep Duration and Metabolic Biomarkers During Pregnancy: A Longitudinal Study in a Multiracial Cohort

Abstract Objective: To examine associations between sleep duration and metabolic biomarkers in pregnant women. Methods: This nested case-control study involved 321 pregnant women from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth...

The extended cascade of type 2 diabetes care in Belgium: a population-based study

Abstract Background Type 2 diabetes (T2D) is a major public health challenge, yet a comprehensive assessment of the quality of T2D care in Belgium is lacking. We therefore developed an extended cascade of T2D care that integrates the traditional care continuum stages with a broad...

Factors Influencing Consumer Engagement in Hospital Care: An Interview Study of Perceptions and Experiences of Patients, Carers and Care Providers

ABSTRACT Aim(s) To explore the challenges and facilitators to consumer engagement in care during hospital attendance, integrating the perspectives of patients, informal carers and care providers. Design A qualitative descriptive study using semi‐structured interviews. Methods A t...

Efficacy of a soft robotic exoskeleton for upper-limb rehabilitation in subacute stroke inpatient rehabilitation: a randomised controlled trial

Soft robotic devices may be a useful adjunct for stroke rehabilitation by providing higher intensity training, while allowing comfort and portability compared to rigid exoskeletons. We evaluated the efficacy of a sensor-assisted soft robotic glove (SSR) during inpatient stroke re...

Lack of Efficacy of Low‐Dose Cyclobenzaprine on Electromyographic Activity Related to Sleep Bruxism: A Randomized Crossover Double‐Blind Placebo‐Controlled Clinical Trial

Sleep bruxism (SB) is a motor activity characterized by repetitive masticatory muscle contractions during sleep, commonly associated with tooth damage and jaw pain or headache. Pharmacological management strategies targeting its central nervous system-related mechanisms remain li...

Machine Learning-Based First-Trimester Antenatal Risk Prediction for Adverse Maternal and Neonatal Outcomes: Multicenter Model Development Study.

Background: Maternal outcomes remain inequitable worldwide. Severe morbidity persists, and current risk assessment tools are largely arbitrary, focusing on biomedical factors while overlooking social determinants of health. There is a need for data-driven AI models to improve ear...

The impact and evolution of environmental/occupational, behavioural, and metabolic risk factors on CVD burdens in the Asia–Pacific region from 1990 to 2023: a secondary analysis of the Global Burden of Disease Study 2023

Background Understanding epidemiological trends of the cardiovascular risk factors is integral in designing effective countermeasures in tackling cardiovascular diseases (CVD) in the Asia–Pacific. The study aims to examine the cardiovascular risk factor burden in the Asia–Pacific...

Implementing telemedicine under polycrisis: a mixed-methods case study from Myanmar using the RE-AIM framework

Myanmar’s March 2025 7.7-magnitude earthquake intersected with conflict, governance breakdown, and economic collapse, leaving 12.9 million people needing health assistance, yet evidence on how telemedicine functions under such polycrisis conditions remains limited. We conducted a...

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Association between prior ICU admission for drug overdose and ICU readmission: A retrospective registry-based study

Objective We aimed to investigate patients discharged alive from hospital following an ICU admission for drug overdose and whether exposure of prior overdose-related ICU admission was associated with a future ICU readmission. Design, setting, participants This multicentre registr...

Phenotypes of painful TMDs and bruxism based on clinical, psychosocial and somatosensory features: a cluster analysis

To identify pain phenotypes among individuals with bruxism and painful temporomandibular disorders (TMD) by integrating clinical, psychosocial, and somatosensory variables. This cross-sectional observational study included 54 adults who self-reported and were clinically assessed...

Tea and cognitive health in aging: Current evidence and future directions

The health benefits of tea drinking have been extensively studied, and in the past 20 years, there has been increasing interest in the role of tea drinking in promoting cognitive health among older adults. This review aims to analyze existing evidence on the benefits of tea drink...

Risk of new‐incident mental health diagnoses following SARS ‐ CoV ‐2 infection amongst children and young adults in Singapore: a retrospective cohort study

Background Mental‐health‐disorders in children/young adults increased post‐pandemic; however, the absence of linkage to COVID‐19 registries made direct attribution of psychological sequelae to acute infection challenging. Methods Healthcare‐claims databases in Singapore were util...