National University Health System

Implementing telemedicine under polycrisis: a mixed-methods case study from Myanmar using the RE-AIM framework

Myanmar’s March 2025 7.7-magnitude earthquake intersected with conflict, governance breakdown, and economic collapse, leaving 12.9 million people needing health assistance, yet evidence on how telemedicine functions under such polycrisis conditions remains limited. We conducted a...

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Association between prior ICU admission for drug overdose and ICU readmission: A retrospective registry-based study

Objective We aimed to investigate patients discharged alive from hospital following an ICU admission for drug overdose and whether exposure of prior overdose-related ICU admission was associated with a future ICU readmission. Design, setting, participants This multicentre registr...

Phenotypes of painful TMDs and bruxism based on clinical, psychosocial and somatosensory features: a cluster analysis

To identify pain phenotypes among individuals with bruxism and painful temporomandibular disorders (TMD) by integrating clinical, psychosocial, and somatosensory variables. This cross-sectional observational study included 54 adults who self-reported and were clinically assessed...

Tea and cognitive health in aging: Current evidence and future directions

The health benefits of tea drinking have been extensively studied, and in the past 20 years, there has been increasing interest in the role of tea drinking in promoting cognitive health among older adults. This review aims to analyze existing evidence on the benefits of tea drink...

Risk of new‐incident mental health diagnoses following SARS ‐ CoV ‐2 infection amongst children and young adults in Singapore: a retrospective cohort study

Background Mental‐health‐disorders in children/young adults increased post‐pandemic; however, the absence of linkage to COVID‐19 registries made direct attribution of psychological sequelae to acute infection challenging. Methods Healthcare‐claims databases in Singapore were util...

A Technology-Blended Exercise Intervention for Cognitive Risk Reduction and Brain Health in Middle-Aged and Older Adults with Type 2 Diabetes in Singapore

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major modifiable risk factor for accelerated brain ageing, cognitive decline, and dementia. However, sustainable lifestyle interventions targeting cognitive health in at-risk older adult populations remain limited. This mixed-metho...

Implant Migration and Dislocation Following Lumbar Total Disc Replacement: A Scoping Review of Risk Factors, Treatment, and Results

<sec><title>Background</title> Lumbar total disc replacement (TDR) is an alternative to interbody fusion for treating symptomatic degenerative disc disease. This approach involves replacing deteriorated lumbar discs with a prosthetic device to alleviate pain and maintain spinal m...

Antibiotic development and a path to access in India

Antibiotic development has historically been concentrated in high-income countries. We discuss how India is emerging as an important centre for antimicrobial development, and the implications for global health and equity of access to life-saving therapies. India is emerging as an...