National Research Council Canada

Altered sperm DNA methylation provides an epigenetic route from overweight and older men to intergenerational disease transmission

The occurrence of childhood neurodevelopmental disorders has been steadily increasing for decades, yet we have little understanding of modes of inheritance implicated in these diseases. Epidemiology studies have revealed an association between an elevated paternal Body Mass Index...

Calcium Isotopic Composition in Reindeer ( Rangifer tarandus ) Bones and Tooth Enamel: A Scalable Tool to Quantify Nursing Frequency in Past and Modern Populations?

RATIONALE: Populations of North American caribou and Eurasian reindeer (Rangifer tarandus sspp.), essential for Arctic ecosystems and human communities, are experiencing unprecedented declines due to climate change and anthropogenic pressures. While understanding their historical...

CHO cell production of a single, enveloped VLP vaccine co-displaying SARS-CoV-2, influenza and RSV antigens

Abstract Concurrent circulation of SARS-CoV-2, influenza A (IAV), and respiratory syncytial virus (RSV) remains a major public health concern, driving the need for multivalent, combined vaccines. Here, we report the generation of trivalent enveloped virus-like particles (eVLPs) c...

Influence of chemical composition on the gassing behavior of biodegradable dielectric liquids: A review

The increasing adoption of biodegradable dielectric liquids in power transformers introduces new challenges for condition assessment, as Dissolved Gas Analysis (DGA) methods developed for mineral oils often yield inconsistent results when applied to alternative insulating fluids....

Assessing the Condition of Concrete Bridge Decks Subjected to Corrosion and Fatigue in a Changing Climate Using Nonhomogeneous Markov Processes

Abstract Bridge deterioration is influenced by material and structural design properties, traffic-induced fatigue, climatic and environmental loads, and maintenance history, all of which may be affected by population growth and climate change. As a result, deterioration rates are...

Size and coating impacts on copper oxide nanoparticle transformations and toxicity to earthworms

Introduction: A key concern for the risk assessment of metallic engineered nanomaterials in the terrestrial environment is the degree to which particle size and functional coatings may alter particle dissolution transformations and subsequent toxicity and bioaccumulation effects....

Fall Risk Identification with Innovative Technologies for Aging in Place: A Clinical Needs Assessment Study

Background: Falls are a leading cause of injury and loss of independence among older adults. While gait-monitoring technologies offer promise for early fall risk detection, adoption is hindered by usability, cost, and integration challenges. Few studies incorporate perspectives f...

Compostable biocomposite PLA/PBSA cast films with TPS and lignin: Properties, biodegradation and ecotoxicity assessment

As the agricultural sector strives for sustainable solutions, the use of biodegradable plastic mulch films continues to garner attention over polyethylene (PE) based films. These eco-friendly alternative films can mitigate the drawbacks of PE film disposal after use, while mainta...

Structural dynamics during the three-ion Coulomb explosion of highly charged CS2 in intense soft x-ray pulses

Using intense femtosecond soft x-ray pulses above the sulfur 2p edge produced by the Free-electron LASer in Hamburg (FLASH), we investigate the multiple ionization and fragmentation dynamics of CS2. We focus on the three-ion fragmentation pathways of CS2 polycations with total ch...

A generalized algorithm for inferring wildfire evacuation decisions and departure times using large-scale mobile device location data

Understanding wildfire evacuation behavior is essential for effective disaster planning, yet current approaches often rely on event-specific methods that limit broader applicability. This paper proposes a generalized algorithm for inferring wildfire evacuation decisions and depar...

Compositional neurosymbolic representations enable efficient active exploration

Abstract Autonomous systems that learn and explore over long horizons face a problem. Standard methods scale poorly in the number of observations, n , precluding sustained operation on bounded hardware. We show that compositional, high-dimensional vector representations inspired...

Proper Orthogonal Decomposition-based Model-Order Reduction for Smoothed Particle Hydrodynamics Simulation—Mass-Spring-Damper System

Model Order Reduction (MOR) based on Proper Orthogonal Decomposition (POD) and Smooth Particle Hydrodynamics (SPH) has proven effective in various applications. Most MOR methods utilizing POD are implemented within a pure Eulerian framework, while significantly less attention has...

An openBIM–openGIS framework for route-aware embodied-carbon assessment in public building procurement

Urban construction supply chains contribute substantially to greenhouse-gas emissions and logistical inefficiencies, partly due to fragmented digital workflows between Building Information Modelling (BIM) and Geographic Information Systems (GIS). This study introduces an openBIM–...

Growth efficiencies of essential fatty acids vary with dietary concentration in Atlantic Pollock (Pollachius virens)

The essential fatty acids (EFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are required for the maintenance of good health in humans. In the marine environment, they are primarily synthesized by phytoplankton and their production is predicted to decrease with warm...