National Research and Innovation Agency

Chamfer effect in the step and Eddy corner of the backward-facing step fluidic oscillator

Abstract A backward-facing step fluidic oscillator (BFSFO) was modified by creating chamfers at step and Eddy corners with variations from 20% to 80%. Analysis was conducted using CFD methods involving an SST k-ω turbulence model. Reynolds numbers ranged from 3 × 10⁴ to 5.5 × 10⁴...

The molecular spectrum of alpha- and beta-thalassemia pathogenic variants in Indonesia: implications for national screening and prevention

Abstract Background Thalassemia is classified globally as a rare disease; however, it represents a major public health burden in many low‑ and middle‑income countries due to its high prevalence and limited access to care. In Indonesia, one of the world’s most genetically diverse...

pH-Driven Structural Optimization of Hydroxyapatite/Alginate Composites for Sustained Clindamycin Release and Antibacterial Applications

Bacterial infections, especially those caused by Staphylococcus aureus and Escherichia coli, still pose a significant challenge for biomedical applications, such as the management of wound and bone infections. This investigation aimed to prepare and characterize hydroxyapatite–al...

Validity of Using Artificial Intelligence to Predict Skeletal Maturation in Orthodontic Treatment: A Systematic Review and Meta-analysis

Abstract This systematic review aimed to evaluate the performance and clinical validation of artificial intelligence (AI) and rule-based methods for skeletal maturation assessment using cervical vertebral maturation (CVM) and hand–wrist radiography. The review was conducted in ac...

Unravelling the genomic potential of sponge-associated Streptomyces sp. BLC 17–3 from Indonesia for mannooligosaccharide production

This research aims to show the promising capacity of Streptomyces sp. BLC 17–3 to produce high β-mannanase enzymes and generate mannooligosaccharide (MOS) such as mannobiose, mannotriose, mannotetraose and mannopentaose when exposed to mannan polymers. Streptomyces sp. BLC 17–3 w...

Intraspecies genetic diversity and host-associated distribution of Endolimax nana in Sumba Island, Indonesia

Endolimax nana is a common intestinal archamoebid within Evosea (Amoebozoa), alongside genera such as Entamoeba , Iodamoeba , and Mastigamoeba . Despite its frequent colonization of humans, it has received limited attention as a presumed non-pathogenic commensal, and its genetic...