National Institutes of Health

Therapeutic NAMPT inhibition reveals a targetable metabolic vulnerability in neuroblastoma

Abstract Background Neuroblastoma (NB) remains a major cause of pediatric cancer mortality for which new therapeutic strategies are needed. Exploitation of reprogrammed metabolic pathways offers an opportunity for cell-type specific anticancer therapeutics. To identify pediatric...

Association between self-reported oral health issues and autoimmune diseases: evidence from UK biobank

Oral microbiome dysbiosis may contribute to autoimmune disease development, but epidemiological evidence linking oral health and autoimmune disease risk is limited. To evaluate the association between self-reported oral health issues by questionnaire—defined as the presence of pa...

A non-neuronal fMRI signal: both a confound and an opportunity for insight

Abstract Functional magnetic resonance imaging (fMRI) is widely used to investigate brain function. However, interpretation of the blood oxygen level-dependent (BOLD) signal is complicated by the fact that it reflects both neuronal activity and vascular physiology. This problem i...

Cell surface ADGRG1 and CD86 expression identifies antitumor CD4 + T cells in human cancer

Adoptive cell transfer of tumor infiltrating CD4 + T cells or T cells genetically modified to express antitumor CD4 + T cell receptors (TCRs) has shown clinical efficacy in patients with advanced solid tumors. We previously defined unique transcriptomic states of antitumor, neoan...