National Institute of Mental Health

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

A Kv4.2-mGluR5 complex drives enhanced depotentiation in a mouse model of improved cognitive flexibility

Memory updating promotes cognitive flexibility by enabling suppression of outdated information to optimize behavioral strategies in response to a changing environment. While some circuits involved have been identified, the synaptic mechanisms underlying this process remain uncert...

Harm Reduction-Oriented Occupational Therapy for Substance Use Disorders: A Retrospective Cohort Study

ImportanceIdentifying factors associated with sustained engagement in harm reduction-oriented occupational therapy may help inform more accessible interventions for individuals with substance use disorders (SUDs).ObjectiveTo examine participant characteristics associated with sus...

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation combined with antidepressants in major depressive disorder: a randomized, double-blind, single-center, sham-controlled trial

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation (DMPFC-rTMS) has shown some evidence of an antidepressant effect. This study aimed to examine the efficacy and safety of DMPFC-rTMS as a combination strategy with concurrently initiated selective serotonin...