National Institute of Mental Health

Ets2 Is an Activity‐Dependent Transcriptional Regulator of a Fast‐Twitch Muscle Program

The functional properties of excitable cells, including skeletal muscle, are regulated by electrical activity. Distinct motoneuron firing patterns control contraction speed, strength, and endurance of fast- and slow-twitch myofibers by activating transcriptional programs that spe...

Single-nucleus atlas of cell-type specific genetic regulation in the human brain

Abstract Genetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression. Although bulk tissue studies have elucidated shared mechanisms of regulatory and disease-associated genetics, the cellular specificity of th...

Anodal Transcranial Direct Current Stimulation Improves Social Behavior Alongside Neuroplastic Changes in a Tsc2 +/− Rat Model of Autism Spectrum Disorder

ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by altered synaptic connectivity and network organization, resulting in profound impairments in social communication and interaction. Transcranial direct current stimulation (tDCS) represents a...

Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling, often irreversible toxicity that affects millions of patients, limits life-saving cancer therapy, and lacks proven treatment. In this work, we show that as little as two doses of psilocybin before chemotherapy dura...

Developing a core competency framework for psychiatric pharmacists: a Europe-wide e-Delphi consensus study conducted by the European Society of Clinical Pharmacy Mental Health Special Interest Group

Abstract Introduction Consensus on essential clinical activities of psychiatric pharmacists is currently unavailable. Agreement on core non-clinical roles relating to research, education, leadership and management is also unavailable. Consensus on the core clinical and non-clinic...

Impact of prompt engineering and workflow modifications on the performance of a Delphi-based automated abstract screening system in a psychiatric systematic review

Large language models (LLMs) can facilitate the labor-intensive screening of literature for systematic reviews and meta-analyses. Ensembling multiple LLMs to reach consensus on screening may allow locally deployed LLMs to achieve acceptable performance while reducing hallucinatio...

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation combined with antidepressants in major depressive disorder: a randomized, double-blind, single-center, sham-controlled trial

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation (DMPFC-rTMS) has shown some evidence of an antidepressant effect. This study aimed to examine the efficacy and safety of DMPFC-rTMS as a combination strategy with concurrently initiated selective serotonin...

Medium-term prediction of clinically relevant outcomes in first-episode schizophrenia patients

Background Predicting long-term outcomes in first-episode schizophrenia (FES) remains difficult, despite being especially important early in the illness, when timely intervention is most critical. It also remains unclear how much data from the initial phase of illness is required...