National Clinical Research Center for Digestive Diseases

PI3K/AKT signaling pathway: molecular crossroads in tumorigenesis and therapeutic innovation

The PI3K/AKT signaling pathway serves as a pivotal regulatory hub that governs essential cellular processes, including growth, proliferation, metabolism, survival, and migration. In the context of tumorigenesis and cancer development, aberrant activation of this pathway drives ma...

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

ABSTRACT Achieving efficient bone repair necessitates a thorough understanding of the physiological activities of native bone tissue, enabling selection and design of appropriate materials. To date, artificial scaffolds have been developed from inert materials to bioactive materi...

Local vs systemic inflammation and outcomes after percutaneous coronary intervention

BACKGROUND AND AIMS: Inflammation influences outcomes after percutaneous coronary intervention (PCI) in coronary artery disease (CAD). This study aimed to evaluate the relative and combined prognostic value of local coronary inflammation, and systemic inflammation for adverse out...

Efficacy and Safety Analysis of Single‐Port Robotic Assisted Cholecystectomy Using a Novel Surgical Platform: A Bicentre, Single‐Arm, Prospective Phase II Clinical Study

ABSTRACT Background Single‐port robotic cholecystectomy offers minimally invasive benefits. This trial evaluated the feasibility and safety of a novel system, MicroPort SA‐1000. Methods In this dual centre, single‐arm, prospective study, eligible patients underwent single‐port ro...

Integrated multiomics reveals a clinically relevant CXCL8-centric protein network in pediatric postinfectious bronchiolitis obliterans

Pediatric postinfectious bronchiolitis obliterans (PIBO) is a long-term sequela of severe lower respiratory tract infection. However, the underlying pathogenic mechanisms within the airways remain poorly understood. Bronchoalveolar lavage fluid (BALF) from six children with PIBO...

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Non-invasive preimplantation genetic testing (niPGT) using cell-free DNA (cfDNA) extracted from spent embryo culture medium (SECM) has shown great potential, providing economic and practical advantages for embryo ploidy testing and quality assessment, while minimizing the risk of...

Merging artificial intelligence and retinal vascular geometric parameters: A novel tool for diagnosis and prognosis prediction of diabetic nephropathy

Abstract Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. The retinal microvasculature, as the only directly observable microvasculature, may reflect DN progression. This study aims to construct a non-invasive diagnostic and prognostic predic...

Transcriptional Profiling of Growth Hormone–Secreting Pituitary Adenoma Stem‐Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications

ABSTRACT Growth hormone–secreting pituitary adenoma (GHPA) can cause excessive growth hormone production, which can lead to clinical symptoms such as acromegaly. Tumor stem cells (TSCs) are postulated to play a significant role in the development of GHPA. We performed RNA sequenc...

Discrimination of the National Early Warning Score versus the 2018 Chinese Emergency Triage Standard for in-hospital mortality in emergency department patients with confirmed high-risk cardiovascular and aortic emergencies: a single-centre retrospective cohort study

Abstract Background The National Early Warning Score (NEWS) is a physiological severity score, whereas the 2018 Chinese Emergency Triage Standard is a categorical triage system used to assign treatment priority. Both use information available at first emergency department (ED) as...

A retrospective comparative study of chronic subdural hematoma in patients with or without decreased level of consciousness

Abstract Background In this retrospective cross-sectional study, we aimed to investigate the effects of preoperative decreased level of consciousness (DOC) on 6-month outcome and the risk factors that compromised the consciousness at admission in patients with chronic subdural he...

Secondary Narrow Nostril Deformity After Unilateral Cleft Lip Repair: Etiology, Classification, and Surgical Strategies

Secondary narrow nostril deformity after unilateral cleft lip repair remains a stubborn clinical challenge, with an incidence of approximately 84%. It compromises both nasal airway function and facial esthetics. The etiology is multifactorial, involving congenital tissue deficien...

Chinese expert consensus on extraintestinal manifestations of inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory condition of the gastrointestinal tract that primarily includes Crohn's disease and ulcerative colitis. Beyond the typical gastrointestinal symptoms, IBD is frequently associated with various extraintestinal m...

Elucidating relationships among upward social comparison on social networking sites (SNSs), depressive symptoms, and SNS addiction in college students: insights from structural equation modeling and network analysis

With the burgeoning prevalence of social networking sites (SNSs), the likelihood of upward social comparison on SNSs has concomitantly escalated, particularly among college students. Notably, upward social comparison on SNSs has been linked to negative emotions and problematic be...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

Pathogenesis of lymphangioleiomyomatosis: from TSC mutations, metabolic reprogramming, to microenvironmental interactions

Lymphangioleiomyomatosis is a rare disease primarily affecting women of reproductive age, characterized by progressive pulmonary cystic destruction and driven by TSC gene loss-induced constitutive mTORC1 activation. Current understanding of the disease extends beyond this primary...

A case of mucopolysaccharidosis I with severely increased albuminuria and Graves’ disease, and functional analysis of previously uncharacterized variant

Abstract Background Mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders which results in accumulation of glycosaminoglycans throughout the body. MPS I is a subtype characterized by mutations in the α-L-iduronidase (IDUA) gene with subsequent multiorga...

Association between living environmental quality and risk of gastrointestinal diseases among middle-aged and older adults: evidence from a national study

Abstract Background With the rapid progression of population aging in China, gastrointestinal (GI) diseases have become one of the most common chronic conditions among middle-aged and older adults, substantially impairing quality of life and increasing healthcare burdens. However...

From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease

Panvascular diseases (PVDs) stand as the leading cause of global mortality, necessitating a paradigm shift from local anatomical repair to the systemic restoration of vascular homeostasis. While intravascular optical imaging has revolutionized diagnosis, it remains a passive obse...

Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology

Orthodontic treatment corrects various craniofacial malformations primarily through triggering active alveolar bone remodeling, however the potential impacts of this intervention on the systemic immune state have long been insufficiently explored. Here, we show that mechanical fo...