National Cheng Kung University

Effects of Dynamic Neck Sensorimotor Biofeedback Training in Individuals With Mechanical Neck Pain: A Pilot Randomized Controlled Trial

Mechanical neck pain (MNP) is commonly accompanied by pain-related functional limitations, sensorimotor disturbances, and fear of movement, which together may contribute to persistent disability. This preliminary randomized controlled trial study investigated the short-term effec...

Reorganization of motor unit discharge-state space during ischemia-assisted fatigue: an energy landscape analysis

Neuromuscular fatigue increases variability in motor-unit (MU) discharge and force output, yet how it reorganizes population-level MU discharge dynamics remains poorly understood. Conventional analytical approaches primarily quantify discharge magnitude, variability, and common s...

TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation

Phosphorylation-targeting chimeras (PhosTACs) enable targeted protein dephosphorylation by recruiting phosphatases through induced proximity. However, the direct recruitment of phosphatase subunits or holoenzymes with small molecules remains challenging, as suitable ligands are s...

Efficient Hot‐Carrier Injection in Gradient‐Nanogap Plasmonic Absorbers for Solar‐Driven CO 2 Reduction

ABSTRACT Efficient light harvesting for photocatalytic CO 2 reduction has attracted considerable attention, yet thin‐film plasmonic photocatalysts often rely on lithography‐based techniques that limit scalability and increase cost, complexity, and reproducibility issues. Here, we...

Adaptive Event‐Triggered Mechanism for Uncertain Unmanned Surface Vehicle Systems Under Sequential Scaling Attacks

ABSTRACT This investigation focuses on adaptive event triggered fault‐tolerant control for uncertain unmanned surface vehicle systems (UUSVs) in the bearing of actuator failures and sequential scaling attacks. In this model, the effects of actuator failures are addressed through...

Latanoprost Acid–Brimonidine, a New Amide Prodrug for Glaucoma Management Based on the Concept of Sustained Release

Glaucoma is an ocular disease caused by the improper management of elevated intraocular pressure (IOP). IOP-lowering via topical administration is the first choice to prevent further progression. However, patients may forget to administer their medication, compromising IOP contro...

Associations between impaired intrinsic capacity and emergency room visits among community-dwelling older adults

Background Emergency room (ER) visits in older adults are associated with increased morbidity and mortality. The World Health Organization’s Integrated Care for Older People (ICOPE) framework assesses intrinsic capacity (IC), but the association between IC impairments and ER visi...

Health Care Stigma and HIV/Sexually Transmitted Infection Prevention Service Uptake Among Cisgender Men and Gender-Diverse Individuals Who Have Sex with Men in Five Asian Countries: Implications for Differentiated Service Delivery

Health care stigma remains a key barrier to HIV and sexually transmitted infection (STI) prevention, yet its effects may differ across health care systems. We examined associations between health care stigma and HIV/STI prevention service uptake across five Asian countries. A cro...

Tumor-derived RPS19 engages C5AR1+ inflammatory macrophages to drive astrocyte reprogramming and glioblastoma progression

Glioblastoma (GBM) is an incurable brain tumor with poor survival outcomes. Its progression and recurrence are strongly influenced by infiltrative growth of tumor cells and tumor microenvironment (TME) components, particularly tumor-associated macrophages (TAMs). To identify pote...

Magneto-Electronically Coupled Quasiparticle Statesin Monolayered MoS2 Driven by the Proximity Effect of UltrathinSmFeO3

Abstract The magnetic proximity effect (MPE) of magnetic substrates provides an effective route to manipulate spin/valley-dependent quasiparticles in two-dimensional transition-metal dichalcogenides (TMDs) without requiring large external magnetic fields. Herein, we demonstrate a...

Effects of Ageism, Depression, Physical Resilience, and Frailty on Quality of Life Among Older Women

In Taiwan, as a super-aging society, older women face unique challenges that affect their health and quality of life (QoL). The present 1-year longitudinal study was conducted to examine changes in physical and psychosocial health and the relationship between these factors and Qo...

Predicting infection risk in rheumatoid arthritis patients receiving biological or targeted synthetic disease-modifying anti-rheumatic drugs: an application of machine learning and healthcare big data

Patients with rheumatoid arthritis (RA) initiating biologic or targeted synthetic disease-modifying antirheumatic drugs (b/ts DMARDs) face elevated risk of serious infections, necessitating tools for individualized risk stratification. Primary objective was to develop and validat...

Prevention of new-onset chronic kidney disease with renin–angiotensin system blockers in type 2 diabetes with preserved kidney function

Renin–angiotensin system (RAS) blockers, including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), are known to slow chronic kidney disease (CKD) progression in patients with established renal impairment. However, whether RAS blockade ca...

Networked Solid Polymer Electrolyte Enabling 5C Fast Cycling and Enhanced Stability of Oriented LiCoO 2 All‐Solid‐State Thin Film Batteries

ABSTRACT Polyethylene oxide (PEO)‐based solid polymer electrolytes (SPEs) have emerged as promising candidates for advancing the all‐solid‐state lithium metal batteries (ASSLMBs) market. However, conventional PEO‐based SPEs exhibit low room‐temperature (RT) ionic conductivity and...

Sulfated PSGL-1 primes the enterovirus A71 fivefold vertex for localized remodeling

Enterovirus A71 (EV-A71) causes hand, foot, and mouth disease and poses a significant public health threat through severe neurological complications in pediatric cases. P-selectin glycoprotein ligand-1 (PSGL-1) functions as an attachment factor, yet the structural basis of PSGL-1...