National Cancer Center

Preclinical characterization and first-in-human phase I dose-escalation results with JYB1907, a novel anti-GARP-TGF-β1 complex monoclonal antibody in patients with advanced solid tumors

Transforming growth factor-β1 (TGF-β1) promotes immunosuppression in the tumor microenvironment via the GARP-latent TGF-β1 complex on regulatory T cells. JYB1907 is a humanized IgG4 monoclonal antibody targeting this complex. Preclinically, JYB1907 bound GARP-latent TGF-β1 comple...

Complete staging surgery and radioiodine therapy were predictive of disease progression of malignant struma ovarii: a retrospective study from a single-center in China and literature review

Malignant struma ovarii (MSO) is a rare subtype of ovarian cancer. We aimed to evaluate the role of complete staging surgery (CSS) and adjuvant radioiodine therapy in this rare malignancy. MSO patients with sufficient information who were treated at the Cancer Hospital & Institut...

Extracellular Vesicles: Emerging Players in Tumor Progression, Diagnosis, and Therapeutic Applications

Abstract Extracellular vesicles (EVs) are emerging as critical players in oncology and also exert vital regulatory effects on exercise-induced muscle injury repair, offering novel insights into tumor biology. Tumor-derived EVs facilitate intercellular communication by carrying bi...

A study to learn how well HER3-DXd (patritumab deruxtecan) works and how safe it is in people with previously treated non-small-cell lung cancer that has a mutation in the EGFR gene: a plain language summary of the HERTHENA-Lung01 study

Plain Language SummaryWhat is this summary about?This is a summary of the publication about the HERTHENA-Lung01 study, which was published in the Journal of Clinical Oncology in September 2023. The study included 277 adults with non-small-cell lung cancer (NSCLC) that had a mutat...

Clinical significance of intramammary lymph nodes in female primary breast cancer: a systematic review and meta-analysis

Intramammary lymph nodes (IntraMLNs), located within the breast parenchyma or axillary tail, are uncommon, and their clinical significance in primary breast cancer remains unclear. This meta-analysis evaluated the association between IntraMLN and axillary lymph node (ALN) status,...

Establishing gender- and age-specific reference ranges for eight tumor markers in adults based on real-world data from Southern China

Abstract Objectives To establish and validate age- and sex-specific reference intervals (RIs) for eight common tumor markers using large-scale real-world data (RWD) and to compare the performance of five indirect statistical algorithms for RI derivation. Methods This retrospectiv...

Evaluation of acute FGF2 and PRDX3 for long COVID prediction across cohorts and proteomic platforms

Abstract Blood proteins measured during acute COVID-19 may help predict Long COVID, but models may fail when moved between cohorts and proteomic platforms. We fitted a reference model using age and sex (C0) in Su/INCOV and a protein model that also included FGF2 and PRDX3 (C2). T...

A dual-tower multimodal framework with feature quality enhancement for predicting pathological complete response after neoadjuvant chemotherapy in breast cancer: a multicenter study

BACKGROUND: Pathological complete response (pCR) is a key endpoint following neoadjuvant chemotherapy (NAC) in breast cancer, with potential to guide treatment adaptation and surgical de-escalation. However, limited generalizability across institutions remains a major challenge d...

Epidemiology and treatment outcomes of bone and soft tissue sarcoma in pediatric and adolescent and young adult patients in Japan: data from population-based National Cancer Registry 2016–2019

This Japanese population-based retrospective study using National Cancer Registry data (2016-2019) revealed age-specific disparities in treatment and outcomes of bone and soft tissue sarcomas in patients under 40 years. A total of 1,209 bone sarcoma (BS) and 3,096 soft tissue sar...

Does a Multi-Location CT Scan Provide a Survival Benefit as Surveillance after Curative-Intent Surgery in Early-Stage Non-Small Cell Lung Cancer?

Purpose: The NCCN guidelines recommend a chest computed tomography (CT) scan every 6 months for 2-3 years for patients with early-stage non-small cell lung cancer (NSCLC). This study aimed to evaluate whether multi-location CT scans offer a survival benefit. Materials and Methods...

Breaking the Lipid Bottleneck: A Mitophagy‐Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy

ABSTRACT Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME‐responsive nanometabolic regulator, ZnO 2 @Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferropt...

The Lactate–Lactylation Axis as a Metabolic–Epigenetic Framework for Therapeutic Adaptation in Esophageal Squamous Cell Carcinoma

Therapeutic failure in esophageal squamous cell carcinoma (ESCC) can arise as tumor cells and their microenvironment adapt to sustained treatment pressure. The lactate–lactylation axis may connect altered metabolism with adaptive treatment responses through changes in protein and...

Deep learning predicts gene rearrangements from histopathology in large B-cell lymphoma

Abstract Large B-cell lymphomas are molecularly heterogeneous mature B-cell neoplasms in which assessment of MYC , BCL2 , and BCL6 rearrangement status contributes to integrated diagnosis, risk stratification, and treatment planning. Fluorescence in situ hybridization (FISH) rema...

Integrated single-cell and bulk RNA sequencing analysis reveals a TPM1-positive myCAF-associated gene signature predicting pancreatic cancer prognosis

Pancreatic cancer (PC) has a poor prognosis, and treatment is largely ineffective because of its unique tumor microenvironment (TME). We identified key cell types in PC using the GSE197177 dataset generated through single-cell RNA sequencing (scRNA-seq) analysis. Using TCGA-PAAD...

Association between annual air pollutant exposure and thyroid function: a retrospective cross-sectional study

Abstract Aims Despite the high burden of air pollutants, the association between air pollutant exposures and thyroid function in the general population is inconclusive. This study aimed to investigate the association between annual exposure to air pollutants and thyroid function...

Hereditary Diffuse Gastric Cancer With Poorly Differentiated Gallbladder Adenocarcinoma: A Case Report Suggesting Carcinogenesis in the Stomach and Gallbladder Caused by a Pathogenic Germline Variant in CDH1

Background/Aim: Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome primarily characterized by a high lifetime risk of diffuse gastric cancer and lobular breast cancer. It is predominantly caused by inactivating germline variants in the tumor suppres...

Successful Management of Ultra-high-risk Mixed Ovarian Germ Cell Tumor Using a Pediatric-inspired Intensive Chemotherapy Regimen: A Case Report

Background/Aim: Non-gestational ovarian choriocarcinoma is an extremely aggressive malignancy with limited standardized treatment protocols. We present a successful multidisciplinary approach for a high-risk mixed malignant ovarian germ cell tumor (MOGCT) containing a predominant...

MIDAS: A multimodal interview-based framework for depression assessment from clinical interviews

Automated depression assessment from clinical interviews is a challenging intelligent healthcare task because depressive states are reflected not only in verbal responses, but also in acoustic and visual-behavioral cues. Existing multimodal methods have improved prediction perfor...

Institutional enrollment volume and clinical outcomes after surgery or chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma: a supplementary analysis of JCOG0502

Abstract Background Surgery and chemoradiotherapy (CRT) are standard options for clinical stage I esophageal squamous cell carcinoma (ESCC). JCOG0502, a multicenter, non-randomized, parallel-group comparison, demonstrated the non-inferiority of definitive CRT compared with surger...

The optimal neoadjuvant modality in locally advanced gastric cancer in the era of immune-drugs: a multicenter retrospective analysis

Optimal neoadjuvant strategies for locally advanced gastric cancer (LAGC) remain contentious. The purpose of this study was to compare the survival prognosis and safety of LAGC receiving three different neoadjuvant modalities. In this multicenter retrospective cohort, 670 patient...