National Cancer Center

P1.100. Impact of Immunotherapy Introduction on Real-World Treatment Patterns for Advanced Esophageal Cancer: A Retrospective Database Cohort Study From Japan

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background Treatment of advanced esophageal cancer (EC) has evolved with immune checkpoint inhibitors (ICIs), including nivolumab or pembrolizumab plus doublet chemotherapy (IO-chemo) and nivolumab plus ipilimumab...

P1.196. Short-Term Outcomes of Robot-Assisted Versus Conventional Thoracoscopic Esophagectomy: A Nationwide Inpatient Database Study in Japan

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Although the clinical application of robot-assisted esophagectomy (RE) has increased globally, its advantages over conventional thoracoscopic esophagectomy (TE)...

P1.084. Exploring the Role of Adjuvant Nivolumab After Neoadjuvant FLOT Followed by Surgery in Resectable ESCC: Implications for Cisplatin-Unfit Patients

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background In Western countries, neoadjuvant chemoradiotherapy (CRT) is standard, and CheckMate 577 showed adjuvant nivolumab prolonged disease free survival (DFS) with non-pathological complete response (non-p...

Surgical resection and angularis oris axial pattern flap reconstruction with adjuvant radiation therapy for recurrent soft palate leiomyosarcoma in a dog

Leiomyosarcoma of the oral cavity is extremely rare in both human and veterinary medicine. To the best of our knowledge, this is the first report describing the clinical course and multimodal treatment of a canine leiomyosarcoma arising in the soft palate. A 3-year-old, spayed fe...

The prognostic value of sarcopenia combined with preoperative C-reactive protein-albumin ratio in patients with gastric signet ring cell carcinoma

Abstract Background Gastric signet ring cell carcinoma (GSRCC) is an aggressive subtype of gastric cancer with poor prognosis. Sarcopenia and systemic inflammation have been linked to adverse outcomes in malignancies. This study aimed to evaluate the prognostic value of sarcopeni...

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer

Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...

Pharmacist–Physician Task Sharing for Anti-MRSA TDM Orders in a Cancer Center: A Retrospective Before-and-After Study

In August 2025, we implemented physician-pharmacist task sharing for therapeutic drug monitoring (TDM) of anti-methicillin-resistant Staphylococcus aureus agents. Before implementation, physicians entered initial and follow-up TDM orders after pharmacist feedback, but afterward,...

Numerical and Interpretive Comparability of Optical and Mechanical Coagulation Analyzers: A Zlog-Supported Method Comparison Study

Background/Objectives: In laboratories using coagulation analyzers with different clot-detection principles and platform-specific reference intervals (RIs), numerical agreement does not necessarily ensure concordant clinical interpretation. We evaluated how analytical agreement a...

Anorectal manometry after rectal cancer surgery: physiological insights, clinical interpretation, and limitations

Abstract Anorectal manometry (ARM) provides objective physiological information on anal sphincter function, rectal or neorectal sensation, reservoir capacity, and anorectal reflexes after rectal cancer surgery. In rectal cancer surgery, ARM has been used to evaluate functional ch...