National Cancer Center

Paradoxical bradycardia from occult venous hemorrhage mimicking vasovagal syncope - A case report -

Background: Hemorrhagic shock typically presents with tachycardia; however, profound hypovolemia can paradoxically induce bradycardia via the Bezold-Jarisch reflex. This can lead to misdiagnosis of vasovagal syncope, causing dangerous treatment delays. Case: A 50-year-old woman d...

Long-term clinical outcomes of moderate hypofractionated proton beam therapy for localized prostate cancer: a single-institution retrospective analysis

To evaluate long-term oncologic outcomes and toxicity of moderate hypofractionated proton beam therapy (PBT) in patients with localized prostate cancer. We retrospectively analyzed 192 patients with localized prostate cancer (cT1–T4N0M0) treated with definitive PBT between 2010 a...

Screening strategies for the early detection of non-cardia gastric cancer in low- to moderate-prevalence regions: Asia-Pacific gastroesophageal cancer congress consensus 2026

Abstract Background Gastric cancer (GC) remains a major global health burden, and early detection is essential for improving patient outcomes. Although GC screening has been widely implemented in East Asian countries with a high disease burden, the optimal screening strategy for...

Clinical Significance of BRIP1 Pathogenic Germline Variant

속하는 ATP 의존성 DNA 헬리케이스를 암호화한다.2001년 Cantor 등에 의해 BRCA1-결합 단백질(BRCA1-associated C-terminal helicase 1, BACH1)로 처음 확인되었으며[1], 이후 연구를 통해 판 코니 빈혈 J형(Fanconi anemia complementation group J, FA-J; MIM 609054)의 원인 유전자임이 밝혀져 FANC...

Clinical Significance of Ataxia-Telangiectasia Mutated Pathogenic Germline Variant

Ataxia-telangiectasia mutated (ATM) encodes a serine/threonine protein kinase that coordinates the cellular response to DNA double-strand breaks.Biallelic pathogenic variants in ATM cause ataxia-telangiectasia, an autosomal recessive multisystem disorder characterized by progress...

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

Postendoscopic Submucosal Dissection Bleeding Risk of Periprocedural Aspirin Maintenance Therapy in Clopidogrel Users as Single or Dual Antiplatelet Agents

Background/Aims: Aspirin maintenance is recommended during endoscopic submucosal dissection (ESD) in patients with antiplatelet therapy (APT) who are at high-thromboembolic risk. We evaluated the post-ESD bleeding risk during aspirin maintenance therapy and the timing of clopidog...

Residential indoor air monitoring to assess long-term exposure to air pollution in susceptible populations for epidemiology: overview and early findings

While there has been accumulating evidence of the association between long-term exposure to air pollution and various health endpoints, most epidemiological studies relied on ambient air pollution which showed substantial deviation from indoor. This difference could lead to biase...

Is Transanal Local Excision Oncologically Safe After Chemoradiotherapy? A Multicenter Phase II Study in ycT0–1 Rectal Cancer

PurposeTo evaluate the feasibility of local excision (LE) as an organ-preserving approach in patients with locally advanced rectal cancer showing a good response to neoadjuvant chemoradiotherapy (CRT). Materials and MethodsThis prospective, multicenter, single-arm phase II study...

Long-term exposure to ambient air pollution and an increased risk of hyperuricemia

Abstract Objectives Evidence suggests that ambient air pollution contributes to metabolic dysregulation, including hyperuricemia. However, previous studies were limited to specific groups or regions with relatively high air pollutant concentrations. This study examined the associ...

Occurrence of New Helicobacter pylori Infections in Healthy, Helicobacter pylori-Negative Adults: A Prospective Observational Study

Objectives: The annual incidence of new Helicobacter pylori infections evaluated by serological test in Korean adults has been reported to be 2.1%–3.3%. This study evaluated the rate of new H. pylori infections using the urea breath test (UBT) and the factors associated with new...

Age- and sex-adjusted genomic differences between Korean and Beat AML cohorts

Genomic profiling plays a central role in risk stratification and therapeutic decision-making in acute myeloid leukemia (AML), yet the clinical implications of population-specific genomic architectures remain incompletely defined. We conducted a prospective, multicenter study of...

Association between annual air pollutant exposure and thyroid function: a retrospective cross-sectional study

Abstract Aims Despite the high burden of air pollutants, the association between air pollutant exposures and thyroid function in the general population is inconclusive. This study aimed to investigate the association between annual exposure to air pollutants and thyroid function...

Successful Management of Ultra-high-risk Mixed Ovarian Germ Cell Tumor Using a Pediatric-inspired Intensive Chemotherapy Regimen: A Case Report

Background/Aim: Non-gestational ovarian choriocarcinoma is an extremely aggressive malignancy with limited standardized treatment protocols. We present a successful multidisciplinary approach for a high-risk mixed malignant ovarian germ cell tumor (MOGCT) containing a predominant...

Early On-Treatment Host Fitness Dynamics Refine Prognostic Stratification in Advanced NSCLC Receiving First-Line Immunotherapy

PurposeWe assessed whether baseline and early on-treatment measurements of host fitness using the Prognostic Nutritional Index (PNI) provide complementary prognostic information in advanced non-small cell lung cancer (NSCLC). Materials and MethodsWithin the prospective, multicent...

Nutritional support for critically ill patients by the Korean Society for Parenteral and Enteral Nutrition—part II: a clinical practice guideline

Purpose: Nutritional therapy is an essential component of intensive care management. Appropriate nutritional support may reduce infectious and metabolic complications and promote recovery in critically ill patients. However, nutritional practices vary across institutions, and int...