Nanyang Technological University

Resolving the Sensitivity–Specificity Trade‐Off in Fluorescent Probes via a Tandem‐Activatable Shielding Strategy

ABSTRACT For precise tumor diagnosis, the intrinsic trade‐off between sensitivity and specificity in fluorescent probes remains a longstanding bottleneck, underscoring an urgent need for strategies to break this fundamental constraint. To address the specificity limitation, we ex...

Biomarker and Bioorthogonality Dual‐Locked Chemiluminescent Probes for Cancer Urine Test

ABSTRACT Bioorthogonality‐activatable optical imaging activates caged or quenched probes via bioorthogonal reactions for disease diagnosis. Although chemiluminescence enables low‐background detection, it has rarely been applied to bioorthogonality‐activatable imaging. Here, we sy...

Heat and mass transfer modeling and performance analysis of a multi-stage coaxial solar-magnetic hybrid distiller based on global energy balance

Dissipation of condensation latent heat constrains the energy utilization, and multi-stage latent heat recovery is a promising strategy to overcome the efficiency limitation of solar-driven interfacial evaporation. Here, we design and demonstrate a multi-stage coaxial solar-magne...

τ-Law-Driven Cross-Level Temporal Optimization for Ultra-Scale Electronic-Photonic Integrated Circuits: Modeling and Experimental Validation

The continuous scaling of semiconductor technology is facing increasing physical limitations, making conventional geometry-driven scaling insufficient for future ultra-scale computing systems. Electronic-photonic integrated circuits (EPICs) provide a promising approach to overcom...

Safeguarding global terrestrial vertebrate species from future sea-level rise

Sea-level rise (SLR) threatens terrestrial biodiversity, yet its spatiotemporal and species-specific impacts remain unclear. Integrating relative SLR projections across five Shared Socioeconomic Pathways (SSPs) with Area of Habitat (AOH) maps for 34,120 terrestrial vertebrate spe...

Calcium looping for post-combustion CO2 capture using sorbents derived from incineration ashes

A method was developed to capture carbon dioxide (CO 2 ) from waste gas streams using ash-derived sorbents via the calcium looping process. The captured CO 2 can be subsequently sequestered in geological formations or utilised to produce fuels and chemicals. This study explored t...

Low-cost single-beam SONAR localization in AUVs: Systematic experiments with acoustic and optical perception

This work presents a low-cost acoustic sensing framework for underwater robot (UWR) localization and perception, using single-beam sonars (SBS) and an external forward-looking sonar (FLS) for confined environments in place of costlier Doppler velocity logs (DVL) and onboard imagi...

Dynamic Mean-Variance Asset Allocation in General Incomplete Markets

Abstract. This paper studies dynamic mean-variance (MV) asset allocation problems in general incomplete markets. Besides the conventional MV objective on a portfolio’s terminal wealth, our framework can accommodate running MV objectives with general (nonexponential) discounting f...

β-CF3 Alkynones for Amine Conjugation under Aqueous Conditions

Abstract We report an aqueous conjugate addition of primary and secondary amines to β-CF3 alkynones under mild conditions without added metal catalysts or activating reagents. This protocol affords stable, CF3-containing enaminone conjugates in phosphate buffer and is applicable...

Reframing Museum Intelligence: A Survey of Large Language Models in Museums

Large language models (LLMs) have recently emerged as a transformative technology for museums, enabling a shift from static content delivery toward interactive and intelligent systems. However, existing studies and deployments remain fragmented, with a lack of systematic analysis...

Liquid-mediated mechanosynthesis of Zn-BDC coordination polymers via ball milling and twin-screw extrusion

Abstract Mechanochemical synthesis methods can offer a low cost, low waste route to prepare metal–organic materials (MOMs); however, the influence of liquid additives on phase formation remains understudied. In this work, the mechanosynthesis of Zn-BDC (BDC = benzene-1,4-dicarbox...

Supramolecular Polymerization of Triphenylamine[3]arenes for Switchable and Stimuli‐Responsive Chiroptical Properties

ABSTRACT The design of advanced photonic materials with integrated stimuli‐responsive properties remains coveted yet challenging. Herein, we demonstrate that chiral supramolecular assembly of triphenylamine[3]arenes (TPA[3]s) offers an efficient and modular solution to address th...

Instability mechanism and failure mode identification of axially loaded CFST columns under lateral impact: A modified 2-DOF approach

Concrete-filled steel tube (CFST) columns are exposed to accidental lateral impact hazards. The instability-driven fracture mechanism under high axial load or intense impact remains unclear, and the quantitative method for identifying instability failure is lacking. To fill this...

Mechanisms and clinical characteristics of organ injury in severe fever with thrombocytopenia syndrome: a comprehensive review

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonotic disease caused by Bandavirus dabieense (commonly referred to as SFTS virus, SFTSV), with a case-fatality rate as high as 30%. Although SFTSV is mainly found in East Asia (China, Japan, and South...

Conjugated Polymer‐Microbe Interactions Trigger Regulatory Reprogramming for Enhanced Bioelectrocatalysis

ABSTRACT Abiotic redox‐active materials are increasingly used to interface with electroactive microorganisms, yet their influence on cellular regulation remains poorly understood. Here, Shewanella oneidensis MR‐1 was coupled with the electron‐transporting conjugated polymer poly(...

Can Non‐Orthogonal Bases Form Stable Skyrmionic Beams?

ABSTRACT Skyrmions, topologically stable spin textures, have recently garnered significant attention in optics, promising robust high‐density information transmission and nontrivial light‐matter interaction. Optical skyrmionic beams have generally been considered to require the s...

A Survey of Robotic Navigation and Manipulation with Physics Simulators in the Era of Embodied AI

Navigation and manipulation are core capabilities in Embodied AI, but training agents to perform them directly in the real world is costly, time-consuming, and unsafe. Therefore, sim-to-real transfer has emerged as a key approach, yet the sim-to-real gap persists. This survey exa...

Dietary and Nutritional Considerations for Metabolic Dysfunction-Associated Steatotic Liver Disease in Psoriasis and Hidradenitis Suppurativa: A Narrative Review

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognised in patients with chronic inflammatory skin disease, particularly psoriasis, for which epidemiological evidence of increased MASLD prevalence is relatively strong; corresponding data in hid...

Neurodegenerative disease risk associated with gene expression in peripheral monocytes across ancestries

Abstract It is hypothesised that peripheral immune states responding to regional environmental triggers contribute to central neurodegeneration. Region-specific genetic selection pressures require this hypothesis to be assessed in an ancestry-specific manner. Here, we utilise gen...

Mind the Gap: An Empirical Study of Synchronization Gaps, Delays, and Missed Opportunities in Software Forks

Fork-based development enables parallel evolution of software, but unsynchronized contributions create persistent divergence: security patches, bug fixes, and quality improvements often fail to propagate across fork families, leaving downstream users exposed to known vulnerabilit...