Nanfang Hospital

Baseline anti-PLA2R antibody titer predicts treatment response and renal outcomes in rituximab-treated membranous nephropathy

Abstract Introduction As rituximab (RTX) has become a first-line therapy for idiopathic membranous nephropathy (IMN), identifying baseline predictors of treatment response is crucial for personalized management. This study was conducted to evaluate whether baseline anti-PLA2R tit...

Senescent cancer-associated fibroblasts secrete Tenascin-C to promote tumor progression in high-grade serous ovarian cancer

Cellular senescence is a hallmark of cancer, and senescent cancer-associated fibroblasts (seneCAFs) contribute to tumor progression across multiple malignancies. However, how seneCAFs promote high-grade serous ovarian (HGSOC) remains unclear. We integrated public single-cell RNA...

Phase separation of PHLDB2 promotes lung adenocarcinoma progression through FLNA stabilization and ERK activation

Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer, but the phase separation-related mechanisms that support its progression remain poorly defined. By integrating phase separation-related gene profiling with prognostic modeling, we identified PHLDB2...

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

ABSTRACT Successful pregnancy requires dynamic extracellular matrix (ECM) remodeling at the maternal‐fetal interface, yet whether individual collagen subtypes actively regulate this process remains unknown. Here, collagen type XXIV alpha 1 chain (COL24A1), a uterine‐enriched fibr...

Regulatory T cells in liver diseases: roles and therapeutic targeting

The liver is an immune-tolerogenic organ in which coordinated interactions between resident and infiltrating immune cells maintain hepatic and systemic homeostasis. Disruption of this balance can lead to chronic inflammation, fibrogenesis, infection, and malignant transformation,...

Stage-specific nanotherapeutics for glaucoma target elevated IOP, impaired aqueous-humor outflow, RGC degeneration, and fibrotic inflammation during postoperative wound healing

Glaucoma is a chronic neurodegenerative disease in which elevated intraocular pressure (IOP), impaired aqueous-humor outflow, retinal ganglion cell (RGC) degeneration, and postoperative fibrosis may coexist or predominate at different stages. Conventional therapies are effective...

Emotional distress and pathological response to neoadjuvant immunotherapy in locally advanced gastric cancer: a multicentre retrospective cohort study

To investigate the association between emotional distress (ED) and pathological response to neoadjuvant immune checkpoint inhibitor (ICI)-based therapy in patients with locally advanced gastric cancer (GC). In this retrospective cohort study (April 2022–December 2024), 129 advanc...

Longitudinal assessment of early childhood caries increment and exploratory dmft progression among children of medical college employees

Abstract Background This study aimed to evaluate the progression of early childhood caries (ECC) and identify its associated risk factors among preschool children of medical college employees. Methods From October 2021 to March 2023, baseline and two follow-up examinations were c...

Decoding the adipose-fibrotic axis: multi-organ mechanisms, crosstalk networks and emerging therapeutic targets

Adipose tissue is a dynamic endocrine and immunometabolic organ that shapes fibrotic remodeling within and beyond its anatomical boundaries. This review synthesizes evidence across skin, heart, liver and intestine to articulate a unifying adipose-fibrotic axis. We highlight depot...

SCADA-informed surrogate modeling and evolutionary optimization for simultaneous exergy, cost, and vibration management in gas turbine systems

The transition toward sustainable industrial power generation requires highly efficient and reliable energy conversion systems. However, balancing thermodynamic performance with economic viability and mechanical integrity under fluctuating operational loads remains a critical eng...

Integrated multi-omics decodes the AKI-to-CKD transition: from ensemble discovery to structure-guided translational targeting

The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) constitutes a major global health burden. Identifying causal drivers remains challenging due to proteomic complexity and confounding biases. We aimed to construct a discovery framework to identify actio...

The impact of big data capabilities and business model innovation on new venture performance

This study develops a mediation framework grounded in dynamic capability and innovation theories to unpack how big data capabilities shape new venture performance through business model innovation. Valid survey responses from 400 Chinese startups operating less than eight years a...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Obstructive sleep apnea as a risk factor for postoperative complications in lumbar spine surgery: a nationwide inpatient sample database study

Obstructive sleep apnea (OSA) is a prevalent sleep-disordered breathing condition associated with systemic comorbidities; however, its specific impact on postoperative outcomes following lumbar spine surgery (LSS) remains under-characterized. This study aimed to determine the evo...

Cognitive function among COVID-19 survivors in the subacute phase during the epidemic of Omicron variant in China

Following the relaxation of pandemic control measures in China, the impact of coronavirus disease 2019 (COVID-19) on cognitive function in the Chinese population has not been investigated. Therefore, this study aimed to assess cognitive function and identify its risk factors in t...

Environmental Statecraft, Fragmented Authoritarianism, and Technocratic Governance: The Structure and Agency of China's Local Environmental Politics

ABSTRACT Local environmental politics in China is often said to be dominated by state‐controlled modes of multi‐level governance. However, top‐down governance is embedded within and transformed by local politics, adding complexity to governance practices and environmental outcome...

An Apoptotic Body‐Mimetic Nanoagonist for Synergistic Diabetic Wound Immunotherapy

Diabetic skin injury (DSI), which are challenging to heal, contribute to global economic losses exceeding US$ 250 billion annually. The impaired healing process is primarily driven by severe local inflammation, excessive oxidative stress, and restricted angiogenesis, with dysfunc...

Genetic prioritization and multi-omic characterization of GNS-associated thromboinflammatory signatures in venous thromboembolism

Venous thromboembolism (VTE) remains a major cause of cardiovascular morbidity and mortality. Beyond dysregulated coagulation, accumulating evidence implicates immune and inflammatory pathways in thromboinflammatory susceptibility. However, the genetic determinants of VTE and the...

Rethinking sympathetic regulation in cancer: From uniform signaling to context-dependent precision targeting

Accumulating evidence has established the sympathetic nervous system (SNS) as a critical regulator of tumor progression, making adrenergic signaling an attractive therapeutic target in oncology. Consequently, β-adrenergic blockade has been widely investigated as a strategy to inh...

Efficacy and Safety Analysis of Single‐Port Robotic Assisted Cholecystectomy Using a Novel Surgical Platform: A Bicentre, Single‐Arm, Prospective Phase II Clinical Study

ABSTRACT Background Single‐port robotic cholecystectomy offers minimally invasive benefits. This trial evaluated the feasibility and safety of a novel system, MicroPort SA‐1000. Methods In this dual centre, single‐arm, prospective study, eligible patients underwent single‐port ro...