Ministry of Health

Health services intervention integrating HTN and HIV care improves long-term blood pressure control among people living with HIV in Uganda

Background Globally, the prevalence of hypertension (HTN) among people with HIV (PWH) has increased dramatically over the last decade. In a cluster randomized trial, we evaluated the effect of a multicomponent intervention model on blood pressure (BP) control among PWH in rural U...

Caregivers’ willingness and factors influencing uptake of the malaria vaccine among under-five children at Masaka Regional Referral Hospital, Uganda

Uganda ranks third with the highest malaria cases globally, highlighting limitations in existing prevention efforts. Malaria vaccination is a key promising strategy to reduce both morbidity and severity among children under 5 (U5) years. In April 2025, Uganda introduced a four-do...

Early insights into predicted efficacy of Ebola monoclonal antibodies for the 2026 Bundibugyo virus disease outbreak

The 2026 Bundibugyo virus disease (BVD) outbreak in the DRC and Uganda raises urgent questions about the efficacy of existing Ebola virus (EBOV) monoclonal antibodies (mAbs) against Bundibugyo virus (BDBV). Here, we perform genomic and structural analyses of 44 BDBV sequences, in...

Analytical performance verification of the Deeplex Myc-TB assay using well-characterized Mycobacterium tuberculosis proficiency testing isolates

Rapid and accurate detection of drug-resistant Mycobacterium tuberculosis is critical for effective patient management and tuberculosis (TB) control. Targeted next-generation sequencing (tNGS) assays such as Deeplex® Myc-TB offer rapid detection of resistance-associated mutations...

Nutrient profiles and labelling practices of marketed packaged processed and ultra-processed foods in Uganda

The consumption of processed and ultra-processed foods is increasing globally and has been associated with an increased risk of diet-related non-communicable diseases (NCDs), partly due to their adverse nutrient profiles. In Uganda, there is limited evidence on whether these prod...

Proteomic Immune Signatures of Severe HIV-Associated Tuberculosis in Sub-Saharan Africa: A Prospective, Multicenter Analysis From Uganda

Abstract Objective Severe tuberculosis (TB) is a major cause of critical illness and death in people living with HIV (PLWH) worldwide. Despite this, the immunopathology of severe HIV-associated TB (HIV/TB) is poorly understood. We aimed to identify an immunopathologic signature o...

Service user and healthcare-worker perspectives on Substance Use Disorder treatment journeys, relapse, and recovery in Sub-Saharan Africa: Evidence from Uganda

Abstract Introduction Substance Use Disorders (SUDs) pose significant public health challenges in sub-Saharan Africa. However, there is limited evidence on how service users (SUs) and front-line health care workers (HCWs) experience SUD treatment and recovery within resource cons...

One Health and antimicrobial stewardship: a call to multi-sectoral collaboration to prevent the emerging epidemic of antimicrobial resistance

A common misconception is that Antimicrobial resistance (AMR) stems solely from poor treatment management in hospitals and weak health systems. AMR is, however, driven by a multitude of factors, including environmental stressors such as contamination from industrial, agricultural...

Cost comparison of community-based vector surveillance using VectorCamTM, an AI-enabled mosquito identification tool, versus routine entomological surveillance in Uganda

Abstract Background National malaria elimination programs depend on timely and reliable vector surveillance data to guide interventions. Current systems rely on analog data collection and microscopy-based morphological identification of mosquitoes by entomologists (vector control...