Ministry of Education

Self‐Assembled Dual‐Drug Nanoparticles for Tumor‐Targeted Delivery and Enhanced Antitumor Chemo‐Immunotherapy

ABSTRACT Insufficient tumor‐targeting accumulation and the immunosuppressive tumor microenvironment (TME) greatly restrict the efficacy of chemo‐immunotherapy. Herein, AWS@PTNC nanoparticles (NPs) are elaborately fabricated via self‐assembly of paclitaxel dimer and serine synthes...

Biotactic Nanodrugs Induce Tumor‐Localized and Durable Embolization via Programmatic Participation in Physiological Biochemical Reactions

The clinical application of tumor vascular obstruction therapy (TVOT) is mainly hindered by imprecise obstruction localization and transient embolic effects. We developed a biotactic nanodrug termed PDA-A@Fib to achieve precise and sustained TVOT by programmatically participating...

Nomograms based on clinical characteristics and baseline dual-layer spectral detector computed tomography imaging parameters: potential clinical utility in predicting the efficacy of first-line lymphoma treatment

Abstract Background Spectral computed tomography (CT) is considered a useful tool for predicting tumor treatment response and survival. However, its role in lymphoma treatment remains unclear. The purpose of this study was to develop spectral CT-based nomogram for predicting resp...

Antibiotic-induced alterations of biogeochemical processes of nitrogen mediated by microorganisms in hyporheic zone and their environmental implications: A systematic review

Antibiotics persist as critical pervasive pollutants within hyporheic zones, exerting selective pressures that disrupt the essential nitrogen (N) cycling. This systematic review synthesises the current evidence on how antibiotic contamination affects microbial community structure...

Lycopene mitigates T-2 toxin-induced systemic inflammation and oxidative stress in association with gut microbiota and SCFAs regulation in mice

T-2 toxin is a trichothecene mycotoxin produced by Fusarium species and can cause disease after contaminated food or feed ingestion. This study aimed to investigate the impact of lycopene (Ly) on systemic inflammation, oxidative stress, and dysbiosis in mice exposed to T-2 toxin....

Targeted microglial ROS-scavenging alleviates neuroinflammation and cognitive deficits via restoration of the 2-AG/CB2R signaling axis in schizophrenia

Cognitive impairment in schizophrenia is inadequately treated. The molecular link between oxidative stress and neuroinflammation in its pathophysiology remains unclear. We measured CB2R in circulating microglia‑derived exosomes from schizophrenia patients and healthy controls. In...

Age-related shifts of dissolved hydrogen and its impact on rumen fermentation dynamics and microbial communities in goats (Capra hircus)

Abstract The rumen is a complex anaerobic fermentation ecosystem in which microbial communities undergo dynamic changes during host development, influencing fermentation efficiency, hydrogen utilization, and methane (CH₄) production. However, how rumen maturation reshapes hydroge...

Deoxynivalenol-induced intestinal toxicity in piglets is mediated by multi-kingdom microbial dysbiosis and metatranscriptomic reprogramming

Mycotoxin contamination of feed and food, particularly with deoxynivalenol (DON), poses significant threats to intestinal health in livestock, yet the role of gut fungi (mycobiota) and fungal-bacterial interactions remains unclear. Across four piglet experiments integrating multi...

Photothermal Superhydrophobic Textiles: An Emerging Paradigm from Passive Water Repellency to Active Thermal Management

Photothermal superhydrophobic textiles represent an emerging paradigm integrating active light-driven functionality with passive liquid repellency. While previous reviews treated superhydrophobicity and photothermal effects in isolation, this work pioneers a systematic analysis o...

Enhancing Mn(II)/Mn(IV) Redox Activity and Reducing Polarization of NASICON‐Type Na 3 MnTi(PO 4 ) 3 Through Al‐Doping

ABSTRACT NASICON‐type cathode materials have garnered significant interest for their stable structure and favorable Na + diffusion pathways. However, Na 3 MnTi(PO 4 ) 3 (NMTP) often suffers from substantial voltage hysteresis and limited capacity, primarily attributed to intrinsi...