Michigan State University

Exploring cerebral small vessel disease signatures in familial Parkinson’s disease

Familial Parkinson's disease (PD) and vascular parkinsonism (VP) present overlapping features and may co-exist. To investigate whether PD and VP may share a potential pathogenic link and to what extent white matter hyperintensities may influence PD phenotype, we used the modified...

Fracture-Controlled Mechanical Behavior of Steel Fiber-Reinforced Ultra-High-Performance Concrete Incorporating Slag and Limestone Powder Under Static and Impact Loading

Ultra-high-performance concrete (UHPC) is characterized by exceptional compressive strength; however, its structural performance is primarily governed by tensile behavior, fracture resistance, and energy dissipation. This study presents a comprehensive mechanical characterization...

A Modular Tecton Matrix for Mechanosynthesis of Large‐Pore Hydrogen‐Bonded Organic Frameworks With Programmable Pore Environments

ABSTRACT Hydrogen‐bonded organic frameworks (HOFs) offer versatile porous architectures, yet predictable pore expansion via tecton extension remains challenging because framework assembly is highly sensitive to solvent‐mediated crystallization. Here, we establish a mechanosynthes...

Temporal Changes in Fungal and Bacterial Communities in Developing Hop Cones and Rhizomes Over a Single Growing Season

Hops are a culturally and economically important crop with centuries of use. The primary harvested component is the hop cone (female flower), which undergoes physiological and chemical changes during development. To better understand the relationship between developing hop cones...

Les Houches study on inclusive jet production at NNLO+NNLL

Jet production at the LHC is a powerful probe of QCD, making it ideal for precision tests and determinations of QCD parameters such as parton distribution functions and the strong coupling constant. To make the most of the abundant jet production data collected at the LHC, precis...

Comparing Spatial Covariance to Common Field Vegetation Metrics

Spatial covariance is a metric used to delineate grassland cores and track state transitions driven by woody encroachment in rangelands, and it does so by calculating the degree of spatial coexistence between functional groups like grasses and trees at different scales. Spatial c...

Development of FamTAM Intervention for Speech and Language Pathologists and Family Members

Children with complex communication needs, including approximately one-third of children with autism, use augmentative and alternative communication (AAC) to meet their daily communication needs. AAC includes gestures, sign language, picture symbols, and computerized systems to a...

Mental Health Care Access in Rural Communities Amid the Expansion of Telehealth

Abstract Introduction Compared to metropolitan residents, rural residents face disparities in access to local mental health providers that are even larger than for other health care services. Telehealth appears to be a solution: patients should be able to more easily access provi...

What makes ornamental cayenne truly desirable? Revealing consumer-preferred traits through agronomic and preference assessment of F5 cayenne breeding lines

Cayenne development is not limited to improving production but also offers opportunities to reach new consumer markets through its aesthetic value. Consequently, cayenne cultivation can be directed towards both functional and ornamental purposes to bolster household food resilien...

Invisible Threats, Relentless Hunters: Biosurveillance of Airborne Plant Pathogens

Airborne dispersal enables plant pathogens to travel across fields, regions, and continents, fueling rapid epidemics and emerging disease threats. Biosurveillance, the systematic monitoring of airborne inoculum, offers the opportunity to detect pathogens before symptoms appear an...

Comparative Genomic Analysis of Clonal Variants of a Spirabiliibacterium Lineage Recovered from a Chicken in the United States

The family Pasteurellaceae includes pathogenic and opportunistic bacteria affecting poultry, yet taxonomic resolution remains challenging due to phenotypic heterogeneity, limited genomic representation, and the poor performance of routine diagnostic systems for uncommon taxa. At...

Effective Tumor Protection by a Tumor-Associated Mucin-1 Glycopeptide-Based Conjugate Vaccine in a Spontaneous Mouse Breast Cancer Model

Abstract Human mucin-1 (MUC1) is an attractive tumor antigen due to its high expression levels on tumor cells and its important roles in tumor development. Due to the aberrant glycosylation of MUC1 on tumor cells, tumor-associated MUC1 (tMUC1) has a shortened O-glycan attached on...

Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

Monogenic syndromes are associated with neurodevelopmental changes that result in cognitive impairments and neurobehavioral phenotypes, including autism and seizures. Limited studies and resources are available to make meaningful headway into the underlying molecular mechanisms t...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...

Two-Step Access to High-Energy Materials via Intrinsic Fuel–Oxidizer Design

Abstract The development of advanced energetic materials that balance high performance with synthetic accessibility remains a formidable challenge in aerospace and defense applications. Here, we report a simple two-step synthetic strategy to access two distinct yet complementary...

Proposing a Role for Maternal Positive Empathy in the Caregiving Relationship

ABSTRACT When mothers empathize with their children, they are motivated to respond in an attuned manner that prioritizes their children's well‐being. A substantial body of research links maternal empathy and attuned caregiving to adaptive socioemotional development in young child...

Local IGF-1 and Akt/mTOR signaling in skeletal muscle of lubabegron-supplemented finishing steers

Abstract Lubabegron (LUB) is a β-adrenergic agonist/antagonist approved for reduction of ammonia gas emissions in feedlot cattle; improvements in growth and carcass yield have also been reported, although the underlying mechanism remains unresolved. Thirty-two Angus-influenced st...

Integrated Analysis of Species Invasion Under the Telecoupling Framework: Burmese Python Across Southeast Asia, the USA, and Beyond

In an increasingly globalizing world, invasive species have become a serious concern worldwide. Numerous studies have focused on the biology of different invasive species, but few have systematically integrated socioeconomic and environmental factors. The framework of telecouplin...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Double orthodontia formulas and Lascoux positivity

We give a new formula for double Grothendieck polynomials based on Magyar’s orthodontia algorithm for diagrams. Our formula implies a similar formula for double Schubert polynomials 𝔖 w ( x ; y ) . We also prove a curious positivity result: for vexillary permutations w ∈ S n , th...