Michigan Medicine

Window-of-Opportunity Study Utilizing Preoperative Cetuximab in Patients with Head and Neck Cancer

Abstract Purpose. AXL, is a receptor tyrosine kinase implicated in EGFR resistance. The primary objective of this study was to test the hypothesis, generated in preclinical studies, that low AXL correlates with clinical response to cetuximab in patients with head and neck cancer...

Mouse bio-behavioral phenotyping using a digital homecage framework for long-timescale, high-resolution, and multi-factor data collection and analytics

Long-term monitoring of behavioral and physiological processes is essential for elucidating complex brain-based phenomena and disorders that develop over extended periods, such as chronic stress, circadian disruption, and metabolic syndromes. Though digital phenotyping is well-es...

Cefepime versus piperacillin-tazobactam for the treatment of Pseudomonas aeruginosa pneumonia

BACKGROUND: Both piperacillin-tazobactam and cefepime are widely used for the treatment of pneumonia caused by Pseudomonas aeruginosa. Despite this, no studies have directly compared these agents for this purpose. METHODS: We performed a single-center retrospective cohort study o...

Talquetamab for people living with relapsed/ refractory multiple myeloma: plain language summary of the MonumenTAL-1 study

Plain Language SummaryWhat is this summary about?This summary describes how well talquetamab worked and its safety at a median (midpoint) of 17–26 months follow-up from the MonumenTAL-1 study, which tested talquetamab treatment for a type of cancer called relapsed/refractory mult...

Characteristics and Timing of Dual Pediatric Palliative Care and Ethics Consultations

Abstract Patients with serious illness hospitalized in the pediatric setting can receive support from Pediatric Palliative Care (PPC) and Ethics Consultation (EC). However, empirical data on dual PPC-EC involvement in pediatrics is limited. Therefore, we characterized ethical iss...

Discovery of Ro 41‐0960, a Non‐Steroidal Inhibitor of the Na + /K + ‐ATPase

The Na + /K + ‐ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure. Yet, cardiotonic steroids used in clinical practice are limited by a narrow therapeutic window and pro‐arrhythmic effects. Here, we identify Ro 41‐0960 as a non...

From Seconds to Seasons and Days to Decades: Timescales in Development

Developmental processes unfold across timescales ranging from seconds to decades, yet temporal assumptions often elude direct theoretical scrutiny. This review illustrates that decisions about timescale, including how time is defined, the density and duration of observations, the...

P1.218. Early Results of Shifting From CROSS to FLOT for Neoadjuvant Therapy Before Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background There has been a shift from CROSS (C) neoadjuvant chemoradiation to FLOT (F) perioperative chemotherapy for esophageal and gastro-esophageal junction adenocarci...

Metabolomic profiling reveals distinct and shared biology in COPD and IPF

Chronic Obstructive Pulmonary disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) are chronic pulmonary disorders with distinct pathologies but shared risk factors. Metabolomics may provide insights into mechanisms. To identify metabolites associated with COPD and IPF, and to...

P1.217. Para-Anastomotic Fluid Analysis as a Predictor for Leak After Transhiatal Esophagectomy: Results From a Pilot Trial

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Anastomotic leak after esophagectomy is associated with poor conduit perfusion and cervical location. Peri-anastomotic fluid acidity (pH) has been shown to be a...

Smart Lithotripsy: Lasers, Energy Sources and Efficiency

PURPOSE OF REVIEW: To examine the evidence on contemporary lasers and provide a practical framework for platform selection, parameter optimization, and thermal safety based on the principles of smart lithotripsy. RECENT FINDINGS: Holmium: yttrium-aluminum-garnet (Ho:YAG) remains...

Persistence in GLP-1–Based Therapy Among Adults with Obesity and Type 2 Diabetes: A Narrative Review of Definitions, Real-World Outcomes, and Determinants

Abstract Purpose of Review Persistence with glucagon-like peptide-1 (GLP-1)–based therapies is important for sustained weight loss and glycemic control in adults with coexisting obesity and type 2 diabetes. This narrative review examined how persistence has been defined and measu...

Racial and Ethnic Differences in Classic and 11-Oxygenated Androgens in Men

BACKGROUND: Androgen-dependent prostate pathology, including prostate cancer and benign prostatic hyperplasia, differs in prevalence and phenotype across races/ethnicities. Adrenal-derived 11-oxygenated C19 steroids (11-oxyandrogens) are relevant to several androgen-dependent pat...

Quantitative computed tomography improves prediction of survival across ILD subtypes

Background Quantitative computed tomography (CT) methods are recognized as valuable tools for risk stratification in fibrotic interstitial lung disease (ILD). Data-driven textural analysis (DTA) is one such approach that correlates with worse lung function and shorter survival in...

Traumatic Catheter Removal‐ At‐Risk Populations, Outcomes and Prevention: A Retrospective Medical Record Review

AIMS: Traumatic catheter removal (TCR) occurs when a urinary catheter is removed with the balloon inflated, causing urethral injury. We aim to identify cases of TCR, determine at-risk populations and describe outcomes and interventions. DESIGN: Retrospective medical record review...

suPAR Identifies Treatment-Resistant Inflammatory Risk Beyond hs-CRP in Type 2 Diabetes With Coronary Artery Disease: An Ancillary Analysis of BARI 2D

OBJECTIVE To determine whether soluble urokinase plasminogen activator receptor (suPAR) is modified by randomized diabetes and revascularization strategies in patients with type 2 diabetes and coronary artery disease and whether combined suPAR and hs-CRP classification refines re...

Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest

Importance Therapeutic hypothermia is widely used for neuroprotection following cardiac arrest, but clinical trials have not consistently demonstrated improved neurological outcomes, and the optimal duration of cooling remains uncertain. Objective To determine the duration of the...

Disparities in Hospital Length of Stay and Morbidity in Acute Care Pediatric Cardiology Patients

BACKGROUND Multicenter collaborative studies examining disparities in in-hospital outcomes are lacking in pediatric cardiology. We hypothesized that Black and Hispanic patients in pediatric acute care cardiology units (ACCUs) have increased length of stay (LOS) and complications...

Lasting Financial and Professional Impacts Among Survivors of Early-Onset Colorectal Cancer

BACKGROUND: Patients with early-onset colorectal cancer (age < 50) are vulnerable to unique psychosocial consequences given their developmental stage in life. Younger adults are often establishing their careers and families, and a cancer diagnosis can contribute to financial and...