Michigan Medicine

Photoinduced Plasmon‐Polariton Mediated Energy Storage

ABSTRACT Development of new means of remotely induced energy storage is important for varied applications, including minimization of energy loss and heat effects in computation devices, solar energy generation, and data transmission. Here, we demonstrate a new concept by which ph...

Association of Early Primary Care Follow-Up With Acute Care Use After ICU Discharge

OBJECTIVE: To determine if early primary care follow-up after pediatric intensive care unit (PICU) hospitalization is associated with reduced acute care use. METHODS: Using claims data from publicly and privately insured children, we identified a cohort of PICU hospitalizations f...

Randomized clinical trial of self-acupressure for aromatase-inhibitor associated musculoskeletal symptoms

Abstract Half of aromatase inhibitor (AI)-treated patients with early stage breast cancer discontinue therapy early, primarily because of AI-associated musculoskeletal symptoms (AIMSS). Acupuncture reduces AIMSS, but uptake is limited. Prior studies demonstrated reduction in pain...

Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish

Most fish are inherently unstable and must swim to stabilize posture. How diurnal fish reduce activity at night while maintaining postural control remains unclear. We defined distinct locomotor strategies that larval zebrafish (Danio rerio) use to control posture and navigate the...

Living With Known Unknowns: Prognostic Uncertainty in Congenital Cytomegalovirus Following Diagnosis

OBJECTIVE: To examine how parents experience and navigate prognostic uncertainty following a diagnosis of congenital cytomegalovirus (cCMV) and identify implications for clinical communication and newborn screening. METHODS: We conducted in-depth qualitative interviews with 41 bi...

Perceptions of Surgeons in Vietnam on International Medical Volunteers

Objective: Short-term surgical missions (STMs) have been used by various organizations to address gaps in the surgical workforce in low- and middle-income countries (LMICs). However, the literature is inadequate in documenting host communities' perceptions of STMs. We aimed to un...

Pro-inflammatory and matricellular protein expression patterns associated with bronchopulmonary dysplasia severity

Abstract Background Pulmonary inflammation and dysregulated repair have been linked to the development of bronchopulmonary dysplasia (BPD), but disease severity varies widely, and the mechanisms leading to BPD heterogeneity remain unclear. We hypothesized that levels of pro-infla...

Efficacy of Tenapanor in Patients With or Without Prior Use of IBS-C Prescription Medications: A Post-hoc Analysis of Phase 3 Clinical Trials

BACKGROUND: Tenapanor is approved for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults. The impact of prior IBS-C prescription treatment(s) on the therapeutic efficacy of tenapanor is unknown. AIMS: To assess whether prior IBS-C prescription medicatio...

Single-nucleus multi-omics reveals reversible molecular signatures in skeletal muscle of patients with heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction (HFpEF) is a complex systemic syndrome characterized by severe exercise intolerance. In addition to cardiac dysfunction, abnormalities in peripheral skeletal muscle are key contributors to reduced exercise capacity in HFpEF. Multiple...

INCREASED PREVALENCE OF PANCREATIC CYSTS IN NONSECRETOR (FUT2 NULL) INDIVIDUALS UNDER PANCREATIC SURVEILLANCE

Abstract Background: Pancreatic surveillance commonly detects pancreatic cysts, most of which are presumed intraductal papillary mucinous neoplasms (IPMN). FUT2, the gene responsible for secretor status, has been implicated in IPMN development, although not with pancreatic cancer...

Cervical cancer screening in China: a mixed methods approach to understanding perception, practice, and prevention

Cervical cancer remains a significant global public health concern, particularly affecting younger women. Despite increasing awareness and national initiatives to encourage prevention, cervical cancer screening among Chinese women aged 18–45 remains suboptimal. This study used an...

Development and Implementation of an Interactive Data Dashboard for Inclusive Public Transit: Design and Dissemination

Public transit systems represent structural conditions that constrain or liberate how people travel through space. However, data documenting the accessibility of public transit systems in the United States (U.S.) is sparse, not nationally integrated, and rarely communicated in pl...

AASLD EXPO: Liver biopsy

Background: Liver biopsy is a foundational tool in hepatology, providing direct histologic assessment of hepatic parenchyma. Although noninvasive approaches have substantially reduced the need for biopsy in practice, it continues to play a critical role in diagnosis, staging, and...

Prognostic implications of complications during VA-ECMO for cardiogenic shock

PURPOSE: Veno-arterial extracorporeal oxygenation (VA-ECMO) provides comprehensive cardiopulmonary support in patients with cardiogenic shock (CS), but may result in complications. While complications rates are known, their impact on risk of death remains largely unknown. METHODS...

Advances in isothermal nucleic acid amplification-based HPV assays for cervical cancer screening in low- and middle-income countries: A scoping review

Objective Cervical cancer disproportionately affects low- and middle-income countries (LMICs), where over 90% of deaths occur and where cost, infrastructure, and low acceptability impede the WHO 2020–2025 goal of elimination by 2030. This review synthesizes advances in isothermal...

Catheter-Associated Urinary Tract Infection Prevention Practices in US Hospitals

Importance Catheter-associated urinary tract infection (CAUTI) remains a common and morbid health care–associated infection. Although evidence-based prevention strategies are well established, the degree to which hospitals adopt and sustain these practices over time and whether t...

Vasoconstrictor therapy for HRS-AKI in patients listed for liver transplantation: Translating evidence to the pretransplant setting

Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a life-threatening complication of decompensated cirrhosis and carries significant implications for liver transplantation (LT) candidacy and outcomes. Terlipressin, a synthetic vasopressin analogue, has emerged as a first-line...

Extracellular Vesicles, Exosomes, and Cancer: Detection and Therapeutic Monitoring

Abstract Extracellular vesicles (EVs) are membrane-bound vesicles released by cells into the extracellular space. Exosomes are a nanoscale subtype of extracellular vesicles (typically 30–200 nm) secreted by almost all types of cells. They carry a diverse molecular cargo, includin...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...