Mianyang Central Hospital

Disaster-related information support systems for families of older adults with special healthcare needs: A scoping review

Based on the theory of structural vulnerability, this study systematically examines the characteristics and underlying mechanisms shaping information needs among families of older adults with special healthcare needs in disaster contexts, providing a theoretical foundation for de...

A randomized controlled trial of internet-based cognitive behavioral therapy for sleep disturbances in ICU survivors

Objective To investigate the efficacy of Internet-based Cognitive Behavioral Therapy (ICBT) for sleep disturbances in patients discharged from the Intensive Care Unit (ICU). Methods A prospective, randomized controlled study was conducted, enrolling 120 patients with sleep distur...

A retrospective cohort study of the association between triglyceride-glucose index and its derived indicators and all-cause mortality among community-dwelling adults with a history of stroke

Abstract Objective As a novel marker of insulin resistance, the triglyceride-glucose (TyG) index has been documented to correlate with mortality in coronary artery disease and heart failure. In recent years, growing attention has been paid to the relationship between the TyG inde...

The proportion of peripheral CD4⁺ cells within CD47⁺ lymphocytes is associated with survival outcomes in diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is clinically heterogeneous, and reliable biomarkers for individualized risk stratification remain limited. Peripheral immune phenotypes may reflect systemic immune competence and influence disease progression. Ninety-eight patients with newl...

Artificial intelligence across the emergency–disaster continuum: a scoping review and implications for nursing practice

Abstract Background Emergency care and disaster response are both characterised by surges in demand, time pressure and constrained resources. In this review, an emergency-disaster continuum was developed as an analytical lens for examining AI applications across routine emergency...

Semi-recumbent position for the prevention of ventilator-associated pneumonia in adults requiring mechanical ventilation

RATIONALE: Ventilator-associated pneumonia (VAP) is associated with increased mortality, hospital stay, and healthcare costs in critically ill patients. Although guidelines recommend a semi-recumbent position for VAP prevention, the evidence remains uncertain due to limitations i...

Efficacy and safety of five femtosecond laser platforms in cataract surgery: a network meta-analysis informing platform-specific clinical decision-making

Abstract Background To compare the efficacy and safety of five femtosecond laser platforms (FLPs) in femtosecond laser-assisted cataract surgery (FLACS) and guide clinical selection. Methods Systematic searches (PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov...

Single-cell and spatial transcriptomics reveal glycolytic remodeling and ENO1-associated metabolic vulnerability in hepatoblastoma

Hepatoblastoma (HB) is the most common malignant liver tumor in children; however, the contribution of glycolytic metabolic reprogramming to HB development and progression remains incompletely characterized. We integrated single-cell RNA sequencing and spatial transcriptomic data...

Recent Advances in Stereoselecive and Enantioselective Difluoromethylation

The difluoromethyl (CF 2 H) group is a valuable fluorinated motif widely utilized in medicinal and material chemistry owing to its unique physicochemical characteristics. This review systematically summarizes recent advances in stereoselective difluoromethylation, classifies the...

The Multi-Layered Effect of Panaxatriol Saponins in Preventing Diabetic Nephropathy in Mice

Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD). Nearly 40% of people with diabetes will develop DN, and DN accounts for 23% of ESRD cases in China. Dysfunction of the gut-kidney axis...