Metropolitan University

Modification Technology for Exosome Membranes using Membrane-Curvature-Sensing Peptides and Its Application to Boron Neutron Capture Therapy

Abstract Extracellular vesicles such as exosomes are expected to be used as drug delivery vehicles, particularly in personalized medicine, due to their pharmacological advantages. However, the development of functionalization techniques for isolated extracellular vesicles—includi...

Reaction of α-Iodoalkyldifluoroboranes with Copper(II) Carboxylates via a Tetracoordinate Boron Intermediate

Abstract The reaction of α-iodoalkyldifluoroboranes with copper(II) carboxylates affords α-acyloxyalkyldifluoroboranes. In this process, the high Lewis acidity of alkyldifluoroboranes constitutes the driving force for the formation of a tetracoordinate boron intermediate, as sugg...

Exploiting Acquired Drug Resistance in Pancreatic Cancer through Selective Covalent Targeting of MAP2K4/7

Pancreatic ductal adenocarcinoma (PDAC) is highly lethal and remains largely refractory to targeted therapy despite its near-universal dependence on oncogenic KRAS. Single-agent KRAS inhibitors often fail due to adaptive resistance mechanisms that emerge under pharmacologic press...