Metro South Health

Temporal patterns and risk factors of clozapine-associated neutropenia: a nationwide population-based cohort study

Background Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, but neutropenia concerns continue to limit its use. Large real-world evidence on temporal risk patterns, re-initiation, and patient-level determinants remains limited. Methods We condu...

Outcomes after discharge from acute hospital to residential aged care among long-stay inpatients: a retrospective cohort study using a health service long-stay dashboard

OBJECTIVE: This study aimed to describe pathway timing and 90-day outcomes for long-stay inpatients discharged to residential aged care homes (RACHs), predominantly new entrants, and to explore potentially modifiable factors associated with delays and the composite unsuccessful p...

Measuring Safer Opioid Use in Hospitals: Development of Consensus-Based Safety and Quality Indicators - a modified Delphi study

BACKGROUND: A significant contributor to preventable medication related harm is opioids. Within Australian hospitals, opioids have contributed to deaths, hospital admissions, and in-hospital related harm. Given these harms, there is a need to ensure opioids are used safely and th...

Co-designing ‘Focus on Frailty’, a digital frailty education course for hospitals: a qualitative study of healthcare professionals’ perspectives

Frailty is associated with negative outcomes and adverse events in hospitals; however, limited formal education on frailty exists in this setting. Healthcare professionals across disciplines have expressed a need and want for frailty education and training. This study aimed to ex...

Hospital in the Home: Lessons from implementing an integrated HITH for Aboriginal and Torres Strait Islander people in South-East Queensland

Hospital in the Home (HITH) can deliver acute-level care at home with comparable or improved outcomes and higher satisfaction than inpatient care. For Aboriginal and Torres Strait Islander peoples, Indigenous-led HITH models may offer particular benefits by combining quality care...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Role of consolidative surgery after chemotherapy in recurrent/metastatic adrenal cortical cancer (ACC): Princess Margaret Cancer Centre experience

Recurrent/Metastatic (R/M) ACC is aggressive with few effective treatment options. The role of surgery after chemotherapy remains unclear. Moreover, prognostic factors in R/M ACC are not well defined. R/M ACC patients treated at Princess Margaret Cancer Centre (2002–2019) were re...