Medical University of South Carolina

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Phenotypic Divergence Among Genomically Closely Related Klebsiella pneumoniae Clinical Isolates

Klebsiella pneumoniae can cause a wide array of infections and exhibit substantial phenotypic heterogeneity depending on the infection site. However, less is known about phenotypic heterogeneity among bacteria isolated from the same infection site. We screened K. pneumoniae clini...

Iatrogenic portobiliary fistula treated with covered stent following percutaneous transhepatic biliary drainage

Percutaneous transhepatic biliary drainage (PTBD) is a common interventional radiology (IR) procedure typically used in the treatment of biliary obstruction when an endoscopic approach has failed or is not technically feasible. PTBD has a low overall complication rate with the So...

Estrogen receptor alpha variants differentially influence proliferation and inflammatory responses in in vitro models of lupus inflammation

Abstract Background Systemic lupus erythematosus (SLE) is an autoimmune disease with female predominance that involves multiple factors, including sex chromosomes, sex hormones, and sex hormone receptor isoforms/variants, such as estrogen receptor alpha (ERα). The mechanisms of n...

DNA Methylation Patterns Between Serous Uterine and Ovarian Carcinomas Indicate Shared Markers with Fallopian Tube Epithelium and Distinctions Consistent with Histopathology

Background/Objectives: Uterine serous carcinoma (USC) is a deadly form of Type II endometrial cancer of rising incidence in the USA. It is currently thought to originate in the uterus, but emerging evidence suggests USC etiology is more complex and may involve the fallopian tube....

Clinical Implementation and Performance of Real-Time AI System for Device Tracking in Neurointervention: First U.S. Evaluation of Neuro-Vascular Assist

Abstract Purpose To evaluate the first U.S.-based implementation, notification accuracy, and temporal operator response of Neuro-Vascular Assist. Methods In a single-center study, 21 consecutive neurointerventional cases were performed using the AI system integrated with a biplan...

How we talk and teach in the operating room: using live operative recordings to evaluate resident autonomy

Abstract Purpose Intraoperative dialogue between faculty and trainees is rich with feedback; however surgical training still relies primarily on delayed, subjective post-procedural written evaluations. We sought to capture and analyze minute-to-minute intraoperative communication...

Implementation of a Nonpharmacological Pain Management Bundle to Improve Postoperative Recovery Outcomes in the PACU

Background: Postoperative pain following laparoscopic procedures can delay recovery and reduce patient satisfaction. Nonpharmacological methods (NPM) provide a low-risk adjunct to pain management. Purpose: This study examined the implementation of a standardized NPM bundle on pos...

HPV-associated Cancer Diagnoses and Mortality in People With HIV in South Carolina During the Antiretroviral Therapy Era

Objectives: We aimed to determine whether people with HIV (PWH) and HPV-associated cancers (HACs) were more likely to be diagnosed at younger ages, at more advanced stages, and have increased mortality. Methods: This is a retrospective cohort study of people diagnosed with HACs i...

Laryngeal Carcinoma Treatment Outcomes in Female Patients

ABSTRACT Objective This study aims to describe characteristics of female patients with laryngeal cancer and to compare surgical and non‐surgical treatment. Methods A retrospective cohort study was performed as a multicenter study with data collected from all female patients diagn...

Recruitment and Engagement in Care to Impact Practice Enhancement for Patients with Sickle Cell Disease: Study Protocol

Abstract Objectives To adapt an evidence-based linkage coordinator model used in HIV care to identify, engage, and link adults with sickle cell disease (SCD) who are unaffiliated from specialty care to SCD specialists, and to assess implementation readiness, processes, outcomes,...

Perceptions of Incidental Findings on Lung Cancer Screening Exams: A National Survey of Primary Care Clinicians and Radiologists

RATIONALE: Unlike other common cancer screenings, annual lung cancer screening often identifies a spectrum of incidental findings unrelated to lung cancer. While these findings could be actionable, how to best communicate and manage them can be a challenge, often falling upon pri...

An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy

BACKGROUND: Evidence of the diverse genetic architecture of dilated cardiomyopathy (DCM) continues to emerge and requires reassessment of the clinical relevance of implicated disease genes. Building on the 2019-2020 Clinical Genome Resource evaluation, the DCM gene curation exper...

Efficacy and Safety of Savolitinib Plus Osimertinib in EGFR-Mutant, MET-Aberrant Advanced Non–Small Cell Lung Cancer

Objectives: NSCLC is the leading cause of cancer-related mortality. While combined therapy including savolitinib and osimertinib appears promising, there exists a lack of comprehensive pooled evidence regarding its anti-oncological activity. : The objective of this study is to ev...

Radiology considerations for the PREMIUM study: a multicenter randomized controlled trial of abbreviated MRI versus ultrasound for liver cancer screening in cirrhosis

Abstract This paper describes the rationale and radiology considerations in the implementation of the Preventing Liver Cancer Mortality through Imaging with Ultrasound versus MRI (PREMIUM) study. PREMIUM is a multicenter, randomized controlled trial sponsored by the Department of...

Perioperative proton pump inhibitors use and postoperative surgical complications following primary total shoulder arthroplasty

Background Proton pump inhibitors (PPIs) are commonly used perioperatively, but their effect on postoperative total shoulder arthroplasty (TSA) outcomes is unclear. The purpose of this study is to determine the effects of perioperative PPIs on surgical complications following pri...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium

Abstract Background Clinical genetic evaluation for patients with dilated cardiomyopathy (DCM) is minimally implemented and models of care are not defined. To understand current genetics care for DCM, a systematic needs assessment was conducted. Methods Principal Investigators (P...

A Clinically Aligned 18-Item Instrument for Measuring Inflammatory Breast Cancer Knowledge

This survey study evaluates preliminary, clinically informed exploratory indices to evaluate inflammatory breast cancer knowledge, including symptom and risk-factor recognition.

Navigating physician-scientist careers: insights from American Board of Internal Medicine Research Pathway graduates

The American Board of Internal Medicine Research Pathway (ABIM RP) is designed to train physician-scientists by shortening postgraduate clinical training and increasing research time. We surveyed ABIM RP graduates to understand career trajectories, research engagement, and barrie...