Medical University of South Carolina

Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity

Glycans play fundamental roles in T cell biology; however, the glycome landscape of γδ T cells remains to be unlocked. Despite the growing importance of γδ T cells in host defense, tissue homeostasis, and diseases, the glycosylation mechanisms guiding their activation, commitment...

Immunoglobulin GM (γ marker) allotypes as potential genetic markers of efficacy of lecanemab therapy in Alzheimer's disease

Lecanemab is a humanized IgG1 monoclonal antibody that targets amyloid-β (Aβ) aggregates, a pathological hallmark of Alzheimer's disease (AD). In the largest clinical trial of its kind to date, lecanemab slowed cognitive decline by 27% in patients with early-stage AD. Lecanemab h...

Mathematical simulations of paediatric haemodynamics in isolated ventricular septal defect

Computer modelling of the cardiovascular system has the potential to revolutionize personalized medical care. This is especially promising for congenital heart defects, such as ventricular septal defect (VSD), a hole between the two ventricles of the heart. However, relatively fe...

Phenolic Metabolites as Therapeutics for Chronic Diseases: One Researcher’s PAINS Is Another’s Translatable Polypharmacology

Abstract Phenols, natural and semisynthetic compounds in which a hydroxylated or oxygenated aromatic scaffold is a defining structural feature, occupy a paradoxical position in drug discovery. On the one hand, these compounds are frequently scrutinized for triggering Pan-Assay IN...

Acute Effects of Impella 5.5 on Biventricular Filling and Pressure–Volume Area in Patients With Heart Failure Associated Cardiogenic Shock

Use of Impella 5.5 in patients with decompensated heart failure-associated cardiogenic shock (ADHF-CS) is increasing as a bridge to advanced therapies. The effects of maximal trans-valvular unloading on biventricular filling and pressure–volume area (PVA) in ADHF-CS are poorly un...

Social Network Theory in Behavior Change Interventions with Black Women to Reduce Inequities in Cardiovascular Health: A Scoping Review of Application and Measurement

Abstract Background Black women in the United States face disproportionate rates of hypertension and cardiovascular disease, driven by the compounding effects of structural inequity and socially embedded stress. Social networks are a critical and underutilized lever for health pr...

Tracking the Impact of Policy on Wheelchair Provision: Insights From 10 Years of Medicare Data

Date presented: April 24, 2026 Primary Author and Speaker: Corey Morrow, morrowco@musc.edu

Who is eligible for lung cancer screening, and where are they? National subpopulation estimates of people eligible for lung cancer screening

BACKGROUND: The utilization of lung cancer screening services is less than 20%. There are a myriad of barriers at the patient, provider, and health care system levels that account for such low uptake. One reason lung cancer screening rates remain low is that identifying who is el...

Nicotine replacement therapy sampling for cigarette cessation in dental care: A National Dental Practice‐Based Research Network cluster randomized clinical trial

BACKGROUND AND AIMS: Cigarette smoking is detrimental to oral health. Oral health professionals rarely prescribe smoking cessation medications. Nicotine replacement therapy sampling (NRTS), providing brief starter courses of NRT, could improve provision of NRT and promote cessati...

AASLD EXPO: Liver biopsy

Background: Liver biopsy is a foundational tool in hepatology, providing direct histologic assessment of hepatic parenchyma. Although noninvasive approaches have substantially reduced the need for biopsy in practice, it continues to play a critical role in diagnosis, staging, and...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

Training the next generation of minimally invasive HPB surgeons: are current fellowships crossing the learning curve?

Abstract Background Minimally invasive surgery (MIS) improved outcomes in hepatopancreatobiliary (HPB) cases, yet adoption is slowed by technical complexity and steep learning curves. This retrospective review sought to characterize MIS training variations across three fellowship...

Patient Perspectives on Offers of Buprenorphine in the Emergency Department

Importance Buprenorphine reduces mortality in opioid use disorder (OUD), and emergency department–initiated buprenorphine (EDIB) doubles 30-day treatment retention, yet many patients decline EDIB when offered. Patient-driven factors limiting uptake are not well characterized. Obj...

AI‐Powered Virtual Patients in Health Professions Education: Learner Engagement and Knowledge Application

PURPOSE/OBJECTIVES: Immersive educational technologies, including applications of artificial intelligence in education (AIED), are increasingly used to develop clinical skills in health professions education. This study evaluated the feasibility and perceived value of integrating...

Brain Stimulation Therapeutic Interventions in Neuropsychiatry: A Cambrian Explosion

Brain stimulation interventions alter neural activity by applying electrical, magnetic, sonic, or other forms of energy to the nervous system, using invasive or noninvasive methods. In recent years, the basic science and clinical science of neuromodulation have markedly advanced,...

Ferroptosis in liver biology and diseases.

Ferroptosis is a form of non-apoptotic cell death driven by iron-dependent lipid peroxidation (LPO). Ferroptosis is closely associated with hepatic metabolic pathways, particularly those involving iron, fatty acids, amino acids, and redox changes. This review aims to provide a co...

Grief in Neurosurgery: Reframing Loss and Identity Through Lived Experience.

Grief is an under-recognized yet pervasive experience in neurosurgery, arising not only from the death of patients and loved ones but also from losses related to professional identity, health, and personal relationships. Despite its relevance, grief is often conflated with burnou...

Heterogeneous Cost Patterns of Episodic Recurrent Vestibular Vertigo in the Medicare Population: A Case-Control Economic Evaluation

Objective To evaluate Medicare costs and healthcare usage with total annual payments comprising hospital, outpatient and prescription costs, neuroimaging, and vestibular and audiometric testing for benign paroxysmal vertigo (BPPV), Ménière’s Disease (MD), and Vestibular Migraine...

Smoking‐induced deprivation and subsequent smoking cessation among adults who smoke in four high‐income countries: Trends, correlates and longitudinal associations, 2016–2024

Abstract Background and aims Tobacco smoking substantially contributes to poverty. Smoking‐induced deprivation (SID) occurs when people continue smoking despite financial stress. This study examined (i) trends in SID in Canada, the United States (US), England and Australia from 2...

Efficacy and Safety of Risankizumab in Paediatric Patients With Psoriasis in the OptIMMize-1 Phase III Study.

BACKGROUND: Treatment options for paediatric patients with psoriasis are limited, and additional, more advanced therapies are needed. Risankizumab is an interleukin-23 inhibitor approved to treat moderate-to-severe psoriasis in adults. OBJECTIVES: To evaluate efficacy and safety...