Medical University of Lublin

Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties

Twelve thiosemicarbazones and 24 corresponding Cu(II) and Pd(II) complexes were synthesised and evaluated for their physicochemical properties and biological activities. Single-crystal X-ray diffraction and mass spectrometry confirmed ligand deprotonation and the formation of neu...

Mechanical and Gravimetric Response of Surgical Suture Biomaterials to Commercial Mouthrinses During Static In Vitro Exposure

Surgical sutures are temporary load-bearing biomaterials whose performance in the oral cavity may be altered by postoperative mouthrinses. Seven USP 4-0 suture materials were immersed in four commercial mouthrinses for 3, 7, 10, and 14 days in a balanced factorial design (n = 3 p...

Sacituzumab govitecan in heavily pretreated metastatic triple-negative breast cancer: a secondary analysis of the CEBCC-102 real-world cohort

Abstract Background Real-world evidence on sacituzumab govitecan (SG) in heavily pretreated patients with metastatic triple-negative breast cancer (mTNBC) remains limited. This study assessed SG outcomes in a multicentre Central European cohort. Methods This retrospective study i...

Childhood Diet, Gut Microbiota and Early Cardiovascular Risk: A Narrative Review

Childhood dietary patterns play a key role in shaping early cardiometabolic risk through effects on adiposity, lipid metabolism, inflammation, insulin sensitivity, and gut microbiota composition. Evidence indicates that atherosclerotic processes begin in early life and are strong...

The evaluation of pharmacotherapy in endometriosis: changes, challenges and difficulties

OBJECTIVES: Endometriosis presents a multitude of challenges for individuals. Current treatment of the disease is based on pharmacotherapy that aims to relieve pain, improves future fertility, potentially slows disease progression and lessen the likelihood of recurrence. The pres...

Comparative RP-HPTLC Lipophilicity Analysis of Bioactive 1,3,4-Thiadiazole–Resorcinol Conjugates

The behavior of bioactive 1,3,4-thiadiazoles of anticancer potency and cholinesterases (ChEs) inhibitors was examined by high-performance thin-layer chromatography (HPTLC) in a reversed phase (RP) system. The chromatographic systems consisted of C-18 or C-8-bonded silica as the s...

Personality Traits and Illness Acceptance in Patients with Cancer and Cardiovascular Disease: A Cross-Sectional Study from Poland

Background: Illness acceptance is a key psychological factor shaping adjustment to chronic disease, and personality traits are among its established correlates. Whether the diagnostic context—oncological versus cardiovascular disease—moderates the relationship between personality...

Self-Rated Health and Persistent Symptoms Among Adults Reporting Previous SARS-CoV-2 Infection: A Cross-Sectional Study

Background/Objectives: Health self-assessment captures perceived physical and psychological well-being. This study described current and recalled pre-infection health ratings, persistent symptoms, and sociodemographic and clinical correlates among adults reporting previous severe...

Mortality Predictors and Retrospective Concordance with ICU Admission Prioritization Guidelines in Patients with Cancer: A Single-Center Cohort Study

Background/Objectives: Advances in cancer treatment and an aging population have increased ICU admissions among patients with cancer, while mortality remains high and ICU resources are limited. We aimed to identify mortality predictors available at admission and factors arising d...

Outcomes and adverse events of postoperative stereotactic interventional radiotherapy/brachytherapy for brain metastases: a systematic review

Postoperative radiotherapy is commonly used after resection of brain metastases, but durable local control with a low rate of adverse events (AEs) remains challenging. This systematic review summarizes outcomes and AEs of postoperative stereotactic interventional radiotherapy (S-...

Discordance between concern and guideline-defined gestational weight gain status: a multicentre cross-sectional study of pregnant women

Concern about gaining too much weight may not correspond to guideline-defined excessive gestational weight gain (GWG) and may instead reflect body-related experiences. We assessed concordance between concern and excessive GWG and associations of concern, weight-related body estee...

Long-Term Sequelae in Patients Treated for Recurrent CNS Relapses of Pediatric B-Cell Acute Lymphoblastic Leukemia: 20-Year Follow-Up, Neurological Consequences, and Survivorship Burden—A Case Report and Literature Review

Central nervous system (CNS) relapse remains a major cause of treatment failure in pediatric acute lymphoblastic leukemia (ALL). Repeated isolated CNS relapse is particularly rare and associated with poor prognosis, while optimal therapeutic strategies remain insufficiently defin...

Nutrition-Related Parameters and Imaging Severity of COVID-19 in Hospitalized Adults: A Secondary Analysis of a Prospective Multicenter Cohort

Background/Objectives: Nutrition-related parameters may be associated with COVID-19 severity, but their relationships with complementary pulmonary imaging measures remain incompletely characterized. This study aimed to examine associations between selected nutrition-related param...

Agentic AI-Enabled Digital Twins for Intelligent Non-Destructive Testing of 3D-Printed Rehabilitation Equipment—A Narrative Review

Digital twins (DTs) based on agent-based artificial intelligence (Agentic AI) provide a transformative framework for streamlining nondestructive testing (NDT) of 3D-printed rehabilitation equipment. This study applies a conceptual research methodology based on the integration and...

Interactions of ACEA and WIN 55,212-2 mesylate with temozolomide and cisplatin in neuroblastoma and glioblastoma cell lines: an isobolographic analysis

Glioblastoma is still the most aggressive primary brain tumor in adults. Recently, several advanced experimental treatment options have been proposed for glioblastoma patients, including the application of cannabinoids as an add-on therapy. In the MTT, LDH, and BrdU assays, the a...

Applicability of HR-ICP-OES in the Pharmacopoeial Assessment of the Uniformity of Elemental Dosages in Food Products for Medical Use

Unlike medicinal products (MPs), dietary supplements (DSs), foods for special medical purposes (FSMPs) and fortified foods (FFs) available on the Polish market are not required to meet pharmacopoeial quality standards. Dose uniformity testing, a pharmacopoeial requirement for MPs...

Morphological, metabolic, and chemical changes in Candida albicans cells induced by the NaQSA complex

This study examines the effects of the sodium complex of quercetin-5′-sulfonic acid (NaQSA) on Candida albicans yeast cells. Flow cytometric analysis showed a concentration-dependent decrease in viable cell numbers after incubation with NaQSA, indicating reduced cellular viabilit...

Structure-guided allosteric modulation of the delta opioid receptor

Abstract Opioid analgesics remain essential for pain management but are associated with significant adverse effects, including respiratory depression, tolerance, and dependence. The δ-opioid receptor (δOR) represents a promising therapeutic target for developing safer opioid anal...

Factors affecting the effectiveness of massive open online course in health professional education: an updated rapid review

A rapid review published in 2020 summarised factors and barriers influencing the effectiveness of MOOCs, to inform decisions regarding health professions education in the early days of the pandemic. No subsequent rapid reviews have updated this work to include evidence produced d...

Efficacy and tolerability of venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia – real-world analysis of Polish adult leukemia study group

We collected clinical data on 363 patients with relapsed/refractory chronic lymphocytic leukemia (RR-CLL) treated with venetoclax-rituximab (VR) in a real-world setting. The median age was 69.5 years (range, 32.5–91.6 years), and the median number of prior lines of therapy was 2...