Medical University of Lublin

Structure-guided allosteric modulation of the delta opioid receptor

Abstract Opioid analgesics remain essential for pain management but are associated with significant adverse effects, including respiratory depression, tolerance, and dependence. The δ-opioid receptor (δOR) represents a promising therapeutic target for developing safer opioid anal...

Factors affecting the effectiveness of massive open online course in health professional education: an updated rapid review

A rapid review published in 2020 summarised factors and barriers influencing the effectiveness of MOOCs, to inform decisions regarding health professions education in the early days of the pandemic. No subsequent rapid reviews have updated this work to include evidence produced d...

Serum CC-Chemokine Profiling in Alcohol-Associated Liver Disease: Focus on MIP-3α/CCL20 as a Biomarker of Disease Severity

Background/Objectives: The inflammatory response is central to the pathogenesis of alcohol-associated liver disease (ALD), yet currently used prognostic scores, including Maddrey’s modified discriminant function (mDF), Child–Turcotte–Pugh (CTP), MELD-Na and MELD 3.0, reflect hepa...

The Quality of Polish Pediatric Healthcare—The First Study of Caregiver Reported Pediatric Oncology Patient Experiences

INTRODUCTION: The aim of this study was, with regard to the state of Poland's pediatric healthcare, to assess user experiences from the perspective of caregivers of pediatric patients and to provide a comprehensive picture of its quality. The research involved cooperating pediatr...

Efficacy and tolerability of venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia – real-world analysis of Polish adult leukemia study group

We collected clinical data on 363 patients with relapsed/refractory chronic lymphocytic leukemia (RR-CLL) treated with venetoclax-rituximab (VR) in a real-world setting. The median age was 69.5 years (range, 32.5–91.6 years), and the median number of prior lines of therapy was 2...

(Z)-3′-(3-Chloro-4-fluorophenyl)-5-fluoro-5′-((6-methoxypyridin-3-yl)methylene)spiro[indoline-3,2′-thiazolidine]-2,4′-dione

A novel spiro[indoline-3,2′-thiazolidine]-2,4′-dione derivative incorporating 3-chloro-4-fluorophenyl and 6-methoxypyridin-3-yl fragments was synthesized and characterized. The synthetic route involved a two-step procedure, including the preparation of the spirocyclic scaffold vi...

KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications - Supplementary Methods

Supplementary Materials and Methods for "KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications" accepted for publication in Haematologica (2026) The published article includes an abbreviated Methods sec...

KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications - Supplementary Methods

Supplementary Materials and Methods for "KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications" accepted for publication in Haematologica (2026) The published article includes an abbreviated Methods sec...