Medical University of Graz

Construction of personal health knowledge graphs for clinical data harmonization in breast cancer

Integrating heterogeneous personal health data and maintaining clinical registries for breast cancer management is labor-intensive. This study presents an AI-powered virtual assistant transforming identifiable breast cancer patient data into interoperable personal health knowledg...

Age-related bone mineral density patterns in a large German clinical DXA cohort: device-specific comparisons with international reference populations

In a large German clinical DXA cohort, comparisons with international reference populations were strongly device-dependent. iDXA values were consistently lower, whereas Prodigy Pro values showed closer but age- and cohort-dependent agreement. The data should not be interpreted as...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Digital solutions for tackling mental health in cancer patients and their families: The ALTHEA project

Despite advances in cancer treatment, the growing global cancer burden underscores the need for comprehensive and supportive care to address the needs of patients and their families. However, access to psycho-oncological support remains often limited across healthcare systems. Th...

From pelvic geometry to modal compliance: sex-specific deformation pathways in the human pelvic ring

Abstract Walking, posture and childbirth all depend on the pelvic ring, yet human pelvic dimorphism is usually interpreted from static birth-canal dimensions. We asked whether sex differences in pelvic function are explained by overall size and static pelvimetry or by available m...

Developmental divergence in gene regulation underlies trophic innovation in Lake Victoria cichlids

Abstract The role of developmental shifts in the emergence of ecological diversity during adaptive radiation remains largely uncharacterized. Here, we investigate the developmental gene regulatory landscape of trophic innovation in the rapid adaptive radiation of cichlid fishes f...

Physiological determinants of endurance capacity in individuals with cerebral palsy: a narrative review

OBJECTIVE: To synthesize evidence on the physiological determinants of endurance capacity in individuals with cerebral palsy. DESIGN: Narrative review. SUBJECTS/PATIENTS: Children and adults with cerebral palsy across the spectrum of motor function (Gross Motor Function Classific...

Clinical management of metachromatic leukodystrophy cases identified in the German and Austrian Newborn screening pilots

Abstract Background Metachromatic leukodystrophy (MLD) is a rapidly progressive leukodystrophy that leads to severe disability and early death if untreated. Autologous hematopoietic stem and progenitor cell gene therapy (HSPC-GT, atidarsagene autotemcel, arsa-cel) for early onset...

Toward the Use of Real‐World Data for Regulatory and HTA Decision‐Making: Experiences and Recommendations from Six EU ‐Funded Projects

Real-world data are increasingly important for regulatory and health technology assessment decision-making, yet their effective use across Europe remains limited by technical, methodological, regulatory, and societal challenges. Drawing on the experiences of six Horizon Europe pr...

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...

Distribution and voltage dependence of ion channels shape single-neuron computations

Voltage-gated ion channels do not distribute evenly in the plasma membrane of a neuron; they localize to distinct domains where they govern the excitability of the cell and the computations it performs. Informed by electron microscopic reconstructions, models of morphologically r...

Early prediction of severe morbidity after liver resection using serum albumin and ALBI-score in a mixed patient cohort

Abstract Background Early identification of patients at risk for severe morbidity after liver resection (LR) remains challenging. Serum albumin and albumin–bilirubin (ALBI) score reflect liver function, but their prognostic value in the immediate postoperative period is not well...

Pattern of ovarian cancer recurrence and survival: final analysis of an extended cohort of 591 patients

Summary This study reports the results of the extended final analysis of the pattern of recurrence and factors influencing survival in 591 consecutive patients with recurrent primary ovarian cancer. Recurrence was arbitrarily defined as the first clinical manifestation of tumor p...

Hypobaric hypoxia at 3,466 m suppresses hepatic bile acid metabolism and remodels the tumor lipidome in mice

Abstract Background Systemic hypoxia induces whole-body metabolic adaptation, but its impact on tumor metabolism and hepatic bile acid (BA) pathways remains poorly defined. Methods We investigated how high-altitude (HA) hypobaric hypoxia at 3,466 m affects tumor growth, tumor lip...

Multimodal imaging reveals no evidence for magnetite-based magnetoreceptors in the mole-rat eye

Magnetoreception is widespread across animals, but its sensory mechanism remains unresolved. One leading hypothesis proposes that single-domain magnetite is coupled to mechanosensitive ion channels. In subterranean Ansell's mole-rats, such receptors have been proposed to reside i...

Long-term survival after allogeneic stem cell transplantation in patients with acute myeloid leukemia

Abstract Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for patients with higher-risk acute myeloid leukemia (AML), but survival is limited by recurrent malignancy and complications such as organ toxicity and infections. This study evaluated ov...

An international position statement on practical approaches for inpatient continuous glucose monitoring, insulin pumps and automated insulin delivery systems in adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and sa...

An International Position Statement on Practical Approaches for Inpatient Continuous Glucose Monitoring, Insulin Pumps, and Automated Insulin Delivery Systems in Adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps, and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and s...

Interest in geriatric medicine training among health and social care professionals: the roles of experience and attitudes. Findings from the online survey of the COST Action PROGRAMMING 21122

Abstract Background The growth of ageing populations is increasing the requirement for professionals trained to care for older adults. Aims To explore factors associated with interest in further training in geriatrics across health and social care professionals. Methods The COST...

Exploring patients' and family members’ perspectives on intensive care unit experiences through unsolicited feedback: A qualitative content analysis

Background Intensive care unit (ICU) stays are profound and distressing experiences for critically ill patients and their family members, often resulting in physical, psychological, cognitive, and social sequelae. Existing knowledge stems largely from structured interviews or que...