Medical College of Wisconsin

Validity of the center for epidemiological studies depression (CES-D) scale for depression screening in postpartum adolescents in Uganda

In Uganda, 25% of pregnancies occur among teenagers and an estimated 20.7% have postpartum depression. Postpartum depression is often underdiagnosed due to insufficient mental health resources and few validated screening tools for adolescent mothers. Addressing this gap, psychome...

Genomic and Transcriptomic Correlates of Deep PSA Response in Patients with Metastatic Androgen Pathway Modulation-Sensitive Prostate Cancer

Abstract Background Despite advances in metastatic androgen pathway modulation-sensitive prostate cancer (mAPMS) treatment, outcomes remain heterogeneous. Achieving a post-treatment undetectable prostate specific antigen (PSA) is a strong prognostic marker. We aimed to identify g...

The Impact of Tablet-Based Screening on Trichomonas Testing in the Pediatric Emergency Department

OBJECTIVES: Sexually transmitted infections (STIs) are a public health concern for adolescents and young adults, with half of STIs diagnosed annually among 15 to 24-year-olds. Trichomonas vaginalis is a high-prevalence STI, linked with increased risk for HIV and premature births....

Trends in Pediatric Firearm Injuries: 2016–2023

BACKGROUND/OBJECTIVES: Firearm injuries (FIs) are the leading cause of death for children and adolescents in the United States. Prior studies noted increases in pediatric FI emergency department (ED) visits early in the pandemic, but long-term trends are unclear. METHODS: We cond...

Adverse events, quality of life, and work impairment in patients with chronic myeloid leukemia (CML)—a survey of first- and second-line tyrosine kinase inhibitor (TKI) intolerance in the US

Tyrosine kinase inhibitors (TKIs) improve survival for people with chronic myeloid leukemia (CML) but may cause adverse events (AEs) that impair quality of life (QoL). Adults with CML receiving first- or second-line TKI therapy in the United States (US) completed validated questi...

GLP-1 receptor agonist use and mental health outcomes in adolescents with obesity: a retrospective review

OBJECTIVES: Adolescent obesity is associated with increased rates of depression and suicidality. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used to treat pediatric obesity, yet concerns remain regarding potential psychiatric effects. This study evaluate...

A Novel De Novo STAG1 Variant at the RAD21 Binding Interface Is Associated With Hypoglycemia, Recurrent Fever, Immunodeficiency and Features of Classical Cohesinopathies

The cohesin complex, composed of SMC1, SMC3, RAD21, and STAG1/STAG2, is essential for chromosome cohesion, DNA repair, and transcriptional regulation. Pathogenic variants in cohesin components cause cohesinopathies. The classical characteristics of cohesinopathies include develop...

Neighborhood Contemporary Redlining and Racial Mortgage Lending Bias and Cardiovascular Outcomes in Women With Breast Cancer

BACKGROUND: Studies have demonstrated neighborhood structural inequities are associated with cardiovascular outcomes among breast cancer survivors. We investigated the associations between bias in mortgage lending practices (contemporary redlining and racial lending bias) and car...

A Comparison of Pediatric Hospitalization Data in Cosmos and the Kids’ Inpatient Database

OBJECTIVE: To compare characteristics of pediatric hospitalizations in Epic Cosmos, an electronic health record-based database that aggregates voluntarily submitted data from across the United States, with nationally representative pediatric inpatient data in the Kids' Inpatient...

Efficacy of student developed and led high value care education in preclinical medical students

The Institute of Medicine estimates that, on average, about one third of all healthcare waste is attributed to unnecessary services. High value care (HVC) is a proposed solution to this problem but is currently underrepresented in preclinical undergraduate medical education (UME)...

Best Case/Worst Case: A Multisite Randomized Trial of Scenario Planning for Patients With Late‐Stage Kidney Disease

BACKGROUND: Best Case/Worst Case (BC/WC) is a communication tool to support nephrologists and older adults with advanced chronic kidney disease with decisions about dialysis. We compared the effectiveness of training nephrologists to use BC/WC versus usual care on receipt of pall...

Safety and Effects of Gildeuretinol Acetate on Retinal Atrophic Lesions in Stargardt Disease

Importance Stargardt disease (STGD) is the most common macular dystrophy, resulting in profound loss of vision. There is no approved treatment. Objective To evaluate the safety and effects of oral gildeuretinol acetate on the growth of retinal atrophic lesions in individuals with...

Wilms tumor: diagnosis and updates

Although Wilms tumor is the most common malignant renal tumor of childhood, it is an overall rare malignancy with a variety of histological appearances. As clinical trials have sought to further identify groups of patients who can benefit from escalation or de-escalation of thera...

Intimate partner violence against Jordanian women: a systematic review of prevalence, associated factors, and health outcomes

Intimate partner violence (IPV) is a pervasive public health problem in many countries, including Jordan. To our knowledge, no systematic reviews have been conducted in Jordan regarding the prevalence of IPV, its associated factors, and related health outcomes. This systematic re...

Na/K-ATPase Signaling in Adipocytes Promotes Atherosclerosis

BACKGROUND: Adipocyte dysfunction is closely associated with oxidative stress and chronic inflammation, which contribute to systemic metabolic disturbances and atherosclerosis. We previously identified the NKA (Na/K-ATPase) α1 subunit as a signal transducer that activates Src-fam...

Pediatric Hospital Medicine Board-Certified and Non–Board-Certified Hospitalists Are Welcome Here

The Consortium of Pediatric Hospital Medicine, representing elected leaders in the field of Pediatric Hospital Medicine (PHM), proudly welcomes and fully supports every pediatric hospitalist, sub-board certified and non–sub-board certified alike, as integral contributors to our c...

Time-dependent divergence in infection risks among patients with multiple sclerosis treated with fumarates versus anti-CD20 monoclonal antibodies

Background: People with multiple sclerosis (pwMS) treated with anti-CD20 monoclonal antibodies have an elevated infection risk, yet long-term comparative data with oral fumarates are limited. Objective: To compare infection incidence, healthcare resource utilization, and relapse...

Adolescent-Centered Cannabis Messaging in Clinical Settings: Preliminary Qualitative Insights From Adolescents for Clinicians

BACKGROUND: Youth-directed cannabis messaging is often generic, adult-centered, and does not reflect contemporary patterns of cannabis use. This study examined adolescents' perceptions of cannabis-related messaging and identified messaging strategies they find relevant. METHODS:...

Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Localized Intermediate-Risk Prostate Cancer

Importance The treatment of prostate cancer with radiotherapy is evolving. How quickly radiotherapy can be delivered, and the relative risks and benefits of such a treatment, is of significant public interest. Objective To determine whether stereotactic body radiotherapy (SBRT) w...

Carbonyl stress promotes ferroptotic susceptibility through lipid metabolic remodeling in renal tubular epithelial cells

Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease worldwide and is characterized by progressive tubular injury, oxidative stress, and metabolic dysregulation. Carbonyl stress, driven by the accumulation of reactive dicarbonyl metabolites such as methylgly...