Medical College of Wisconsin

Historical Baseline Electrocardiogram Ascertainment Prior to Cancer Diagnosis and Cardiovascular Diagnosis Patterns in Cancer Survivors: A Retrospective Observational Cohort Study

Background: Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality among cancer survivors. Contemporary cardio-oncology frameworks emphasize baseline cardiovascular risk assessment before potentially cardiotoxic cancer therapies. Historical real world imp...

An Adolescent With Neurosyphilis

Neurosyphilis is a central nervous system (CNS) infection that has become exceedingly rare in the postantibiotic era, especially in children and HIV-negative persons. It can develop during any stage of an untreated syphilis infection and is known as "the great imitator" for its h...

Interim Update on Reactive Infectious Mucocutaneous Eruption ( RIME )

ABSTRACT Reactive infectious mucocutaneous eruption (RIME), a term describing blistering skin and mucosal lesions, is a term coined by a group of Pediatric Dermatology Research Alliance (PeDRA) researchers and first published in 2021. Since that time, the literature has grown wit...

Imputed Rare‐Variant Aggregate Analysis Is a Powerful Approach to Detect Genetic Associations

ABSTRACT Imputation can cost‐effectively generate genotypes for millions of variants. This study evaluated the power of performing rare‐variant aggregate association tests using imputed genotypes. UK Biobank exome‐sequence data and variants obtained via imputation using the HRC (...

Transient receptor potential channel activation targets multiple stages of the schistosome parasite

Schistosomiasis, a neglected tropical disease caused by infection with parasitic blood flukes of the genus Schistosoma , affects more than 250 million people worldwide. Currently, patients rely on a single medicine, praziquantel (PZQ), discovered half a century ago. To combat dru...

A qualitative comparison of 3 law enforcement deflection programs for people who use drugs (PWUD) in Wisconsin

Due to the high cost of imprisonment and high rates of recidivism, there are a growing number of programs working to divert individuals involved in non-violent drug offenses away from arrest, jail and prison. Deflection programs are those that refer people who use drugs (PWUD) to...

Grief in Neurosurgery: Reframing Loss and Identity Through Lived Experience.

Grief is an under-recognized yet pervasive experience in neurosurgery, arising not only from the death of patients and loved ones but also from losses related to professional identity, health, and personal relationships. Despite its relevance, grief is often conflated with burnou...

Brain structure correlates of circulating endocannabinoids and related lipids in early adolescents

Abstract The endocannabinoid (eCB) system underlies many biological processes and is thought to be critical in adolescent brain development. However, the eCB system’s contributions to brain morphometry during adolescence remains understudied. Here we investigated cross-sectional...

Machine-perfused Donation After Circulatory Death Grafts Improve Access to Liver Transplant for Primary Biliary Cholangitis Patients.

Background: Primary biliary cholangitis (PBC) is a small-duct cholangiopathy that can lead to end-stage liver disease requiring liver transplantation (LT). Use of donation after circulatory death (DCD) donors in this population has been limited by historic concerns of severe bili...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Real‐world outcomes of nivolumab‐ AVD and brentuximab vedotin‐ AVD in paediatric and adult advanced‐stage Hodgkin lymphoma

Summary Brentuximab vedotin (BV)‐doxorubicin, vinblastine and dacarbazine (AVD) and nivolumab (N)‐AVD have transformed the frontline treatment of advanced‐stage Hodgkin lymphoma (HL), yet real‐world comparative data remain limited. In this multicentre retrospective study across 1...

A functionally distinct HPA ‐1a‐specific alloantibody associated with fetal/neonatal alloimmune thrombocytopenia that activates platelets via FcγRIIa

Abstract Background Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal alloantibodies directed against fetal platelet antigens, most commonly human platelet antigen‐1a (HPA‐1a). These antibodies mediate platelet destruction and can lead to fetal and neonatal...

Disruption of local CTCF binding impairs renin expression and blood pressure response in Dahl salt-sensitive rats

Most genetic variants associated with any complex trait are found in non-coding regions. Multiple studies have reported enrichment in single nucleotide polymorphisms (SNPs) found in specific sequences bound by CCCTCF-binding factor (CTCF). CTCF binds DNA to establish boundaries,...

Medial temporal default mode network selectively encodes autobiographical visual imagery

The human brain’s capacity to imagine visual scenes from memory is thought to rely on the medial temporal subsystem of the default mode network (MT-DMN), yet the neural codes supporting this ability remain poorly understood. We combined functional magnetic resonance imaging (fMRI...

Peripartum Decompensation of an Orbital Vascular Malformation Managed With Urgent Postpartum Surgical Decompression

Abstract: A 36-year-old woman at 36 weeks gestation presented with 5 months of pain on upgaze and 2 months of progressive vision loss in the right eye. Examination revealed 20/200 acuity, a relative afferent pupillary defect, proptosis, motility restriction, disc edema, and visua...

Germline Genomic and DNA Methylation Differences Between MGUS and Multiple Myeloma Among Patients of African Ancestry

Individuals of African ancestry (AA) have approximately twofold higher risk of multiple myeloma (MM) than individuals of European ancestry, yet the molecular determinants between monoclonal gammopathy of undetermined significance (MGUS) and MM remain poorly defined. We performed...

Supine Versus Standing Pelvic Radiographs Yield Significantly Different Radiographic Parameters in Femoroacetabular Impingement and Hip Dysplasia: A Systematic Review and Meta‐analysis

Purpose To compare radiographic parameters obtained from supine versus standing pelvic radiographs in patients with femoroacetabular impingement (FAI) and acetabular dysplasia (AD). Methods This study was registered on the International Prospective Register of Systematic Reviews...

Flourishing and the Future of US Medical School Admissions

US medical school admissions have been under increasing pressure from state and federal governments, while contending with the implications of the 2023 US Supreme Court decision that ended race-conscious admissions. Change is necessary, but few have offered ideas for how best to...

Comparison of Visual Feedback Conditions While Learning a Redundant Novel Visuomotor Task

Human movement relies on coordinating multiple degrees of freedom (DOFs) converging onto fewer DOFs of functional goals. We compared two forms of visual feedback as participants learned a novel motor task: using 18-DOF finger movements to control a 3-joint kinematic chain, ultima...

Validity of the center for epidemiological studies depression (CES-D) scale for depression screening in postpartum adolescents in Uganda

In Uganda, 25% of pregnancies occur among teenagers and an estimated 20.7% have postpartum depression. Postpartum depression is often underdiagnosed due to insufficient mental health resources and few validated screening tools for adolescent mothers. Addressing this gap, psychome...