Mazandaran University of Medical Sciences

Elucidating an explanatory model for cancer care management within the urban family physician setting in Iran: a qualitative grounded theory study

Cancer care management requires coordinated and continuous services across prevention, diagnosis, treatment, and supportive care pathways. Despite ongoing efforts to strengthen primary healthcare in Iran, an integrated framework explaining how cancer care can be organized within...

Mechanistic insights into the role of hypoxia-preconditioned mesenchymal stem cell-derived small extracellular vesicles in angiogenesis, adhesion, emt, and tumor progression in solid tumors

Solid tumors harbor a highly hypoxic tumor microenvironment (TME) that plays a pivotal role in tumor progression, therapeutic resistance, and metastasis. Mesenchymal stem/stromal cells (MSCs) are actively recruited into these hypoxic regions, where they undergo phenotypic reprogr...

Demographic resilience of Anopheles stephensi to synthetic detergent (surfactants) pollution: life-table responses and implications for urban malaria transmission

Environmental contamination of freshwater habitats is increasingly recognized as a factor influencing the ecology of disease vectors. In this study, we used life table-based analyses to examine the effects of three concentrations of sodium dodecylbenzene sulfonate, a detergent/su...

Association of total and source-specific dietary nitrate and nitrite with subclinical atherosclerosis in young adults

Atherosclerosis, a chronic process originating in young adulthood and progressing silently to clinical cardiovascular disease, highlights the need to identify modifiable nutritional exposures. Epidemiological evidence regarding their association with subclinical atherosclerosis i...

Antibacterial efficacy of Nonea lutea-mediated silver and gold nanoparticles against multidrug-resistant clinical pathogens harboring virulence and resistance genes

INTRODUCTION: The emergence of high-level antibiotic-resistant bacteria, such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus, represents a critical global health threat that requires novel therapeutic strategies. The use of Green-synthesized gold an...

Intratumor microbiota in thyroid cancer: emerging insights into tumorigenesis and therapeutic potential

Thyroid cancer incidence has risen sharply in recent decades, yet the mechanisms underlying tumor development and progression remain incompletely understood. Recent evidence reveals that tumors, including thyroid malignancies, harbor distinct microbial communities, termed intratu...

Aureocin A53 as a therapeutic agent against drug-resistant mycobacteria including M. tuberculosis and non-tuberculous strains

The global rise of tuberculosis (TB) and increasing drug resistance in Mycobacterium tuberculosis ( M. tuberculosis ) highlight the urgent need for novel antimycobacterial agents. Antimicrobial peptides (AMPs), particularly bacteriocins, offer promising therapeutic options or adj...

Coumarin-triazole hybrids as potent low-toxicity anticancer agents evaluated by in vitro and in vivo 99mTc-MIBI uptake in glioblastoma models

Abstract Glioblastoma is the most aggressive primary malignant brain tumor in adults. This study examines the anticancer potential of twenty innovative coumarin-based 1,2,4-triazole derivatives, alone and in a combination with paclitaxel, against various human cancer cell lines a...

Psychometric features of the Patient-Centered Communication Scale among Iranian clinical nurses

Background Measuring patient-centered communication seems essential from the perspective of nurses as the primary healthcare providers. The Patient-Centered Communication Scale (PCCS) is one of the instruments that makes it possible to achieve this goal. Therefore, since no versi...

Psychometric properties of the Persian version of Pressure Ulcer Management Self-Efficacy Scale for nurses

Background: Pressure ulcers remain a major clinical challenge, and nurses’ self-efficacy is essential for their prevention and management. The Pressure Ulcer Management Self-Efficacy Scale (PUM-SES) for nurses was developed to assess this competency. Aim: This study aimed to tran...

Engineering CAR-NK cell platforms for breast cancer: metastatic interception, perioperative control, and emerging platelet-guided biomimetic strategies

Breast cancer metastasis remains the leading cause of disease-related mortality, highlighting the need for strategies that can intercept circulating tumor cells, suppress micrometastatic outgrowth, and eliminate residual disease during the perioperative window. Although CAR-T cel...

Epidemiology and antimicrobial resistance patterns of bloodstream infection pathogens in northern Iran

Bloodstream infection (BSIs) is life-threatening conditions associated with increasing antimicrobial resistance (AMR), particularly in low- and middle-income countries. Local surveillance data are essential to guide empirical therapy and antimicrobial stewardship. This study aime...

Anti-methicillin-resistant Staphylococcus aureus (Anti-MRSA) flavonoids from Iraqi Citrus sinensis (L.) Osbeck

Citrus sinensis (L.) Osbeck (Rutaceae) was investigated as a potential source of anti-MRSA compounds. A bioassay-guided isolation approach afforded fourteen compounds from the peel and leaf extracts of C. sinensis , including a new flavanone glycoside, sinensidin ( 10 ). Structur...

Intermittent fasting in diabetic retinopathy: microbiome modulation, mechanisms, and clinical insights.

Intermittent fasting, a nonpharmacological approach, shows promise for controlling diabetic retinopathy but lacks concrete human evidence directly associating intermittent fasting with eye responses. This review highlights preclinical research insights about intermittent fasting...

Platelet–neutrophil cooperation in premetastatic niche formation: from NETosis and stromal conditioning to nanotherapeutic interception

Metastasis remains the leading cause of cancer-related mortality, yet the metastatic cascade is initiated long before circulating tumor cells reach distant organs. Central to this early phase is the premetastatic niche (PMN), a dynamic and tumor-conditioned microenvironment in wh...

Assessing the concordance between ultrasonography and MRI for evaluation of structural features in knee osteoarthritis: a prospective cross-sectional study

Abstract Background Knee osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by progressive structural and functional impairment. While magnetic resonance imaging (MRI) is regarded as the reference standard for assessing joint pathology, ultrasonography (...

Fabrication and evaluation of a polymeric muco-adhesive film with local and controlled release of phenytoin: an in vitro investigation

Phenytoin has long been used to accelerate wound healing. The aim of this study is to design, fabricate, and evaluate some properties of a polymeric mucoadhesive film with slow release of phenytoin. In this in vitro study, polymers such as Hydroxypropyl Methylcellulose, Sodium ca...

Green synthesis of silver nanoparticles using Senecio vernalis and evaluation of their multifunctional biomedical, sun protection factor and catalytic degradation activities

Green synthesis has emerged as a safe and sustainable alternative to conventional chemical methods because it avoids the use of toxic reagents and enables environmentally friendly nanoparticle production. In this study, silver nanoparticles were prepared through a green approach...

Concurrent infection with Clostridium chauvoei, Clostridium septicum and Clostridium perfringens type A in cattle: a case report

Blackleg, caused by Clostridium chauvoei , is an acute, fatal infectious disease characterized by necrotizing myositis and toxemia primarily affecting cattle and sheep. Gas gangrene (malignant edema), a similar necrotizing myositis, is caused by multiple anaerobes including C. ch...

Spatial patterns and factors associated with suicide death among individuals with suicide attempts in northern Iran

Suicide is a major global health concern causing over 720,000 annual deaths, with most occurring in low- and middle-income countries. Official reports in Iran demonstrate increasing and regionally varied patterns, with distinctly elevated risk levels observed in certain province....