Massachusetts Department of Public Health

Lung Function–Associated Genetic Variants and Overall Survival in Non–Small Cell Lung Cancer: A Multi-Platform Analysis

Abstract Background: Genome-wide association studies (GWAS) have identified numerous variants associated with spirometric lung function, and Mendelian randomization studies suggest that impaired pulmonary function contributes to lung cancer susceptibility. Whether these variants...

Sexually transmitted infection testing among U.S. adolescents in relation to U.S. Preventive Services Task Force screening guidelines

BACKGROUND: This study examined whether sexually transmitted infection (STI) testing patterns aligned with U.S. Prevention Services Task Force (USPSTF) screening recommendations among a large sample of U.S. adolescents. METHODS: Data were from Inclusive Care and Access to Resourc...

Contribution of Adolescent Movement Behaviours to Socioeconomic Inequalities in Adult Cardiovascular Disease Risk: A Causal Decomposition in a Population-Based Cohort

Abstract Addressing unhealthy movement behaviours in adolescence could reduce socioeconomic inequalities in adult cardiovascular disease (CVD) risk. Among 6608 adolescents enrolled in the Add Health cohort (1994-1995) and followed into adulthood (2016-2018), movement behaviours (...

Multilevel factors associated with nonresponse to patient-reported outcome measures in routine radiation oncology care

Nonresponse to routinely collected patient-reported outcome measures (PROMs) threatens the representativeness of aggregated data. We characterized patient-, provider-, and clinic-level factors associated with PROMIS Global-10 nonresponse in routine radiation oncology care. In thi...

The impact of a randomized controlled trial of a lifestyle intervention on postpartum physical activity among predominantly Puerto Rican women with overweight and obesity: Proyecto Mamá

Engaging in physical activity during pregnancy decreases the risk of gestational diabetes and excessive weight gain, thereby reducing postpartum risk of type 2 diabetes and postpartum weight retention. Such long-term adverse health outcomes disproportionately affect Hispanic wome...

Machine learning–driven spleen imaging and genomics uncover a splenic connection to coronary artery disease

Despite advances in managing traditional risk factors, coronary artery disease (CAD) remains the leading cause of mortality. Circulating hematopoietic cells influence risk for CAD separately from traditional risk factors, but the role of a key regulating organ, the spleen, is unk...

Military Service and Survival Among Persons With ALS in the U.S. National ALS Registry, 2011–2023

ABSTRACT Introduction/Aims Military service has been associated with increased risk of amyotrophic lateral sclerosis (ALS) but less is known about survival after diagnosis. We evaluated the association between military service and survival after ALS diagnosis among U.S. National...

“I Just Need Guidance Through This Maze I’m Going Through”: Addressing Unmet Basic and Mental Health Needs to Facilitate Engagement in HIV Prevention Services in the Context of Stimulant Use

There is a global syndemic of HIV, mental health challenges, substance use, and structural barriers. Critical to local HIV prevention efforts is understanding this syndemic in the context of rising stimulant use to inform intervention development. Adhering to the EPIS model, we c...

Gestational Diabetes Mellitus: Recurrence and Future Type 2 Diabetes Risk Across Racial and Ethnic Groups

OBJECTIVE Despite rising diabetes prevalence among women, data on long-term diabetes risk following gestational diabetes mellitus (GDM), particularly its recurrence, remain limited, especially for Asian women. This study examined associations among GDM, its recurrence, and subseq...