Institution
Mass General Brigham
Recent research
- Health & Medicine
Intraoperative Botulinum Toxin and Sialocele Incidence After Parotidectomy
ABSTRACT Objectives Postoperative sialocele is a complication of parotidectomy and, in some cases, may require multiple follow‐ups or necessitate needle aspiration. The purpose of this study was to assess whether intraoperative botulinum toxin A injection is associated with decre...
- Health & MedicineOpen access
Artificial intelligence in clinical trials—state of the evidence, gaps, and next steps
Artificial intelligence (AI) affects clinical trials in two distinct but overlapping ways: as the intervention under evaluation and as infrastructure supporting trial design, recruitment, monitoring, endpoint assessment, analysis, and reporting. In this manuscript, we define AI-a...
- Health & Medicine
Despite advances in managing traditional risk factors, coronary artery disease (CAD) remains the leading cause of mortality. Circulating hematopoietic cells influence risk for CAD separately from traditional risk factors, but the role of a key regulating organ, the spleen, is unk...
- Health & MedicineOpen access
Summary Vertically transferred maternal cells or maternal microchimeric cells (MMCs) engraft the fetus and persist in offspring for long periods of time. How altered maternal immune states arising from infection affect MMCs and their function in offspring is poorly understood. He...
- Society & Economics
ABSTRACT Objective To characterise the clinical and phenotypic profile of the Comprehensive Risk Evaluation for Anorexia nervosa in Twins (CREAT) cohort, identify candidate risk and illness‐related correlates of AN, and establish a foundation for forthcoming biological, neuroimag...
- Health & MedicineOpen access
BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...
- Health & MedicineOpen access
Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM
BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...
- Health & Medicine
Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy
BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...
- Health & MedicineOpen access
Abstract Introduction Cardiotocography (CTG) is widely used for monitoring fetal heart rate (FHR) and uterine activity (UA) during pregnancy and labor. Clinician interpretation of CTG tracings may be subjective, leading to significant inter‐ and intra‐observer variability and inc...
- BiologyOpen access
Abstract Oncology notes contain the richest clinical detail, yet they remain largely inaccessible at scale because extracting structured phenotypes requires either substantial language model infrastructure, curated training data, or cloud computing under regulatory constraints. W...
- BiologyOpen access
Multimodal models capable of imputing diverse data used in single-cell biology studies provide potential foundational opportunities in clinical practice. However, patient data uniquely comprise longitudinal mosaic measurements that reflect underlying physiological dynamics and ex...
- Health & MedicineOpen access
Care Team Response to Patient Portal Message Content and Writing Style
Importance Patient portal messages are an increasingly central channel for patient-clinician communication, but there are inequities in how responsive care teams are to messages sent by patients from historically marginalized groups. The reasons driving these disparities are not...
- Health & Medicine
Food protein-induced allergic proctocolitis: an early step on the atopic march
PURPOSE OF REVIEW: Food protein-induced allergic proctocolitis (FPIAP) has traditionally been considered a benign, non-immunoglobulin E (IgE)-mediated condition of infancy without long-term consequences. This review examines evidence challenging this framework and discusses FPIAP...
- Health & Medicine
Introduction The Lattice flow diverter is a novel mechanical balloon-based device designed to enhance wall apposition and optimize aneurysm neck coverage. Yet, its safety, efficacy, and angiographic outcomes have not been systematically evaluated. Methods A systematic review and...
- Health & MedicineOpen access
Functional Activity of TDP-43: A Direct Biomarker for ALS
TDP-43 dysfunction is a defining feature of amyotrophic lateral sclerosis (ALS), yet no biofluid biomarker directly measures its functional activity. We developed a serum-based homogeneous time-resolved FRET (hTR-FRET) assay that quantifies TDP-43 RNA binding activity using synth...
- Health & Medicine
SDHC c.397C>T- Related Pheochromocytomas and Paragangliomas: Insights from an International Study
BACKGROUND: The SDHC c.397C>T (p.Arg133Ter) germline pathogenic variant is present in over 40% of mutation-positive paragangliomas in French-Canadian patients, supporting a founder effect. We aimed to characterize pheochromocytomas and paragangliomas (PPGLs) associated with this...
- Biology
Papillary Hyperplasia in Autosomal Dominant Polycystic Kidney Disease
Renal cysts in autosomal dominant polycystic kidney disease (ADPKD) frequently harbor small intracystic epithelial proliferations that arise in continuity with the cyst lining and are distinct from other recognized proliferative lesions or well-defined renal tumors and lack a for...