Mass General Brigham

Prognostic Significance of Contrast Enhancement in Newly Diagnosed Grade 2 IDH-mutant Glioma

Abstract Background Contrast enhancement is generally considered an adverse prognostic feature in adult glioma. However, its significance in newly diagnosed grade 2 IDH-mutant glioma remains uncertain, with important implications for use of the mutant IDH inhibitor vorasidenib. W...

GVHD ‐Associated Angiomatosis: An Overlooked Vascular Sequela of Chronic Graft‐Versus‐Host Disease

ABSTRACT Graft‐versus‐host disease‐associated angiomatosis (GVHD‐AA) is a rare clinicopathologic variant of chronic GVHD characterized by benign vascular proliferations arising within areas of sclerodermatous skin change. The entity was formally named in 2014 and presents clinica...

Spontaneous resolution of vestibular schwannoma: A singular phenomenon

Background: The natural history of vestibular schwannoma (VS) is variable, with concerns about observation management rather than hearing loss. Shrinkage is well documented, with an undetermined hearing outcome. Case Description: We report the case of a 62-year-old female followe...

RINGSIDE Phase II Study of Varegacestat for Treatment of Desmoid Tumors: A Randomized Dose-Finding Clinical Trial

PURPOSE Desmoid tumors (DTs) are rare, often locally aggressive, connective tissue neoplasms with limited effective treatment options. We evaluated the safety and efficacy of varegacestat, an oral gamma-secretase inhibitor. METHODS RINGSIDE phase II was an open-label, randomized,...

Willingness to Participate in HIV Cure Research Among Young People Living with Perinatally Acquired HIV in the Centre Region of Cameroon: A Cross-Sectional Survey

Young people living with perinatally acquired HIV (YPLHIV) represent a unique population for HIV cure research, offering opportunities to assess interventions in a group for whom adherence to antiretroviral treatment (ART) is particularly challenging. Understanding their perspect...

Impact of Extent of Surgical Resection on Survival in Patients With High-risk Neuroblastoma

Objective: The impact of extent of resection of the primary tumor on outcomes in patients with high-risk neuroblastoma (HRNB) remains uncertain. We evaluated this issue in patients with HRNB treated on a prospective trial of multimodality therapy. Summary of Background Data: Pati...

A multiomic atlas reveals distinct immune landscapes in preterm and term chronic placental inflammation

Chronic placental inflammation (CPI), an umbrella term encompassing chronic chorioamnionitis, chronic villitis, and chronic deciduitis, is associated with preterm birth (PTB), yet its cellular and molecular determinants across gestation remain poorly defined. Here, we constructed...

Mechanism-Targeted Therapy in Adult Obstructive Sleep Apnea: Aligning New Treatment Modalities with Pathophysiological Endotypes

Advances in Positive Airway Pressure (PAP) technology, including novel pressure algorithms such as Kairos PAP, aim to improve comfort without compromising efficacy. Pharmacologic therapies have emerged as viable options, with tirzepatide demonstrating substantial reductions in ap...

Sensitivity to ATR–CHK1 pathway inhibition in MDS/AML is enhanced by SRSF2 mutations and reduced by RUNX1 loss

Abstract SRSF2 mutations occur in 5–15% of acute myeloid leukemia (AML) and ~15% of myelodysplastic neoplasms (MDS), are enriched in elderly/secondary AML, and lack mutation-directed therapy. We aimed to identify vulnerabilities in MDS/AML with SRSF2 mutations. Ex vivo drug-sensi...

Antithrombotic-associated bleeding: management in the emergency department.

The expanding use of antiplatelet agents, anticoagulants, and fibrinolytics has made bleeding emergencies more frequent and more complex. A structured, evidence-based approach enables emergency clinicians to identify life-threatening and critical-site bleeding, initiate resuscita...

The global cost of schizophrenia: a health economic modelling study

Abstract Background Schizophrenia is a chronic psychiatric disorder that leads to substantial disability, impaired quality of life, and reduced life expectancy. In addition to its profound impact on affected individuals, the disorder places a considerable financial burden on heal...

Decomposing diagnostic criteria in neurology: a scoping review of components and structure to inform criteria development

Abstract Background Diagnostic criteria are critical for the accurate diagnosis of neurological diseases, which are among the most challenging to define. They help to standardize global efforts in healthcare delivery and scientific investigation. Despite their importance, no stan...

Reducing Serum Bilirubin Measurements in a Newborn Nursery Using Quality Improvement Methodology

BACKGROUND: Transcutaneous bilirubin (TcB) screening in the newborn nursery (NBN) is noninvasive and appropriate for most infants; however, reported rates of total serum bilirubin (TSB) measurement remain at 17% to 30%. OBJECTIVE: From January to December 2024, 17.2% of infants s...

RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair

Aging and tissue repair involve heterogeneous remodeling across transcriptional, biochemical and cellular dimensions, yet prevailing definitions rely on isolated molecular markers that obscure how these states co-evolve. Here we present RamanOmics, a multimodal framework integrat...

Utility and best practices for clinical diagnostic testing of the autonomic nervous system: A Consensus Statement Endorsed by the American Autonomic Society and the American Association of Neuromuscular & Electrodiagnostic Medicine

Abstract Purpose Disorders of the autonomic nervous system are prevalent and associated with substantial morbidity, mortality and diagnostic delay. Standardized, laboratory-based autonomic function testing provides objective physiological data essential for diagnosing, staging, a...

Modifiable Lifestyle Factors in Cardiovascular Disease Prevention: Current Evidence and Future Directions

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide despite substantial advances in pharmacologic and interventional therapies. Modifiable lifestyle behaviors are major determinants of cardiovascular risk and essential targets for primary a...

Multilevel factors associated with nonresponse to patient-reported outcome measures in routine radiation oncology care

Nonresponse to routinely collected patient-reported outcome measures (PROMs) threatens the representativeness of aggregated data. We characterized patient-, provider-, and clinic-level factors associated with PROMIS Global-10 nonresponse in routine radiation oncology care. In thi...

Program-Level Neoadjuvant Chemotherapy Use and 10-Year Survival in Advanced Ovarian Cancer

This comparative effectiveness research examines the association between neoadjuvant chemotherapy adoption by US cancer programs and 10-year survival among patients with advanced ovarian cancer.

A Mixed Methods Quality Improvement Evaluation of a Dedicated Virtual Rounding Team for Home Hospital Care

Background Importance Home hospital is the delivery of acute, hospital-level care at home as a substitute for traditional brick-and-mortar care. Most past literature includes a care model where home hospital providers visit the patient at home. Due to the inefficiencies of travel...

Patterns of Index Endovascular Compared With Surgical Revascularization for Femoropopliteal Disease in Patients With Claudication Using Medicare-linked Data

OBJECTIVE: To compare outcomes of endovascular versus open infrainguinal bypass in patients with claudication. SUMMARY OF BACKGROUND DATA: PAD research has focused largely on CLTI, yet 20% of patients present with claudication and may not improve with medical therapy alone. Durab...