Marche Polytechnic University

mRNA Vaccines as Novel Immunotherapeutic Approaches in Gastrointestinal Cancers

Messenger RNA vaccines have moved rapidly from the infectious-disease area into oncology. They now represent an attractive therapeutic option for gastrointestinal (GI) cancers. Personalised constructs, designed to elicit tumour-specific T-cell immunity, have shown acceptable safe...

Polycyclic aromatic hydrocarbons in loggerhead sea turtles (Caretta caretta) embryos: Occurrence, tissue distribution and associated biological responses

Maternal transfer of environmental contaminants represents a critical pathway that occurs during the early life stages of marine vertebrates, however, the occurrence and the fate of polycyclic aromatic hydrocarbons (PAHs) in sea turtle embryos remain poorly characterized. This st...

MARMADE Deliverable 1.1 – Map of marine biomass sources and hotspots

Deliverable D1.1 of the MARMADE project provides a comprehensive mapping of marine biomass sources and hotspots across Europe to support the development of circular bio-based value chains for food and feed ingredients. The deliverable focuses on two priority value chains: crustac...

Enhanced coupling efficiency in geometric terahertz rectennas based on scalable CVD graphene

Ubiquitous electromagnetic radiation from wireless communication networks is an untapped energy source for low-power devices. Passive rectennas (a combination of a rectifier and an antenna) can harvest this energy to power devices and systems, such as autonomous sensors. Rectenna...

Future Generations' Perceptions and Evaluations of Financial Intermediaries: A Multivariate Analysis in the Digital and Sustainable Era

ABSTRACT The rapid digital transformation of financial services, increasing regulatory pressure and the growing strategic relevance of sustainability are reshaping financial intermediaries and how they are perceived by younger generations. In this context, traditional monetary co...

More immersion, better experience? The trade-offs of haptic gloves and treadmill locomotion in virtual museums

Abstract Virtual Reality (VR) is increasingly adopted in cultural heritage to enable interactive exploration of artefacts that cannot be physically handled in museum settings. Despite growing interest in advanced interaction technologies such as haptic gloves and VR treadmills, e...

Substance Use during Pregnancy: A Retrospective Multicenter Clinical Report from Four Italian Centers

Background: Rising substance use during pregnancy is a major global health concern associated with adverse maternal and neonatal outcomes. Despite growing international literature, Italian real-world multicenter data remain limited. Methods: We conducted a retrospective descripti...

Validation of the Malay Version of the Cognitive Fusion Questionnaire-7 (CFQ-7-M)

Introduction/ Objective This study aimed to translate and validate the Malay version of the Cognitive Fusion Questionnaire-7 (CFQ-7-M) among Malay-speaking, Malaysian university students. The CFQ-7 measures cognitive fusion, a key ACT process that reflects the extent to which ind...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

OnabotulinumtoxinA Improves Sleep Quality in Patients with Chronic Migraine: A Prospective Real-World Study

Sleep disturbances are highly prevalent in patients with chronic migraine (CM) and are increasingly recognized as major contributors to disease burden and headache chronification. Growing evidence suggests that dysregulation of calcitonin gene-related peptide (CGRP) signaling and...

The impoverishing effect of tobacco expenditures

Tobacco consumption is a major source of health and financial burden, yet evidence on its association with household poverty remains limited. This study examines how tobacco-related expenditures are associated with both the incidence and depth of poverty in Albania. Using nationa...

Aflibercept 8 mg for diabetic macular edema and neovascular age-related macular degeneration: an italian expert consensus paper

To provide consensus recommendations on the clinical use of aflibercept 8 mg in managing neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the real-world setting. A modified Delphi study was undertaken, involving ophthalmologists from special...

Ultrasound-Guided Collagen Peptides Injections Combined with Focused Extracorporeal Shockwave Therapy and Therapeutic Exercise in Chronic Partial Common Extensor Tendon Tears at Elbow Lateral Epicondyle: A Retrospective Case Series

Background: Lateral elbow tendinopathy (LET) is a common upper-limb musculoskeletal disorder causing pain during gripping activities, reduced work capacity, and functional limitation. LET is currently considered a predominantly degenerative condition characterized by collagen dis...

Poincaré inequality and quantitative De Giorgi method for hypoelliptic operators

We propose a systematic approach based on trajectories to prove a Poincaré inequality for weak non-negative sub-solutions to hypoelliptic equations with an arbitrary number of Hörmander commutators, both in the local and in the non-local case. As a consequence, we deduce the weak...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

Ultrasound-Assisted Osmotic Pretreatment of Myrtle (Myrtus communis L.) Berries with Grape Molasses: Impacts on Convective Drying Quality

Myrtle berries are rich in bioactive phenolics and volatile terpenes and have potential for use in functional food products. However, the combined application of grape molasses and ultrasound as a pretreatment before drying has received limited attention. This study characterized...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Retrohepatic Vena Cava Encirclement, as Surrogate of Extensive Liver Manipulation During Caval Sparing Hepatectomy, Is a Risk Factor for Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma

ABSTRACT Introduction In liver transplantation (LT) with a caval sparing (CS) approach, the presence of complete encirclement of inferior vena cava (IVC‐E) by hypertrophic segment 1 increases the technical complexity of hepatectomy. Thus, in LT for hepatocellular carcinoma (HCC),...

Global trends in pleural infection mortality: a WHO-mortality database analysis

Background Current data suggest that the incidence of pleural infection is rising worldwide, however mortality data on global rates, trends and variations are lacking. Objectives To estimate pleural infection mortality rates across 24 Countries from 1994 to 2020 worldwide, using...

Knowledge design in complex domains

Traditional Knowledge Engineering (KE) often fails to address modern complex domains characterized by "wicked problems," where non-stationary ground truths and high dimensionality render static rule sets obsolete. This paper proposes a paradigm shift from traditional Knowledge En...