Marche Polytechnic University

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Dual-Kinetic Relaxation Spectroscopy for Discrimination of Volatile Organic Mixtures via Finite-Size Surface Gratings

Abstract Discrimination of chemically similar volatile organic compounds (VOCs) in gas mixtures remains a challenge for traditional optical refractive index sensors. In this work, we used a surface holographic grating relaxation technique to monitor the transport kinetics of VOCs...

Role of ERK1 and ANP as potential forensic biomarkers in hypothermia conditions: An experimental study

Diagnosing fatal hypothermia remains a forensic challenge due to the lack of specific postmortem markers. This study investigates the potential of extracellular signal-regulated kinase 1 (ERK) and atrial natriuretic peptide (ANP) as biochemical indicators in hypothermia-related d...

Impact of live-in care workers on health and well-being of older people with long-term care needs and their primary informal care providers during the Covid-19 pandemic in Italy

This study aimed to assess the impact of privately hired live-in care workers (LICWs), many of whom have a migrant background, on overall health status, emotional/psychological status and quality of life of older people with long-term care (LTC) needs and their primary informal c...

Regime-Dependent Effectiveness of Spectral Nudging in WRF–Chem: Meteorological and Saharan Dust Skill over the Central Mediterranean

Regional WRF–Chem dust simulations may require continuous integrations when state continuity is scientifically important, yet extended limited-area runs can depart dynamically from the driving analysis. We use a two-tier controlled design that separates dynamical attribution from...

Impact of GLP-1 Receptor Agonists on Cognitive Performance in Adults at Risk of Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background/Objectives: Type 2 diabetes, a widely recognized risk factor of Alzheimer’s disease (AD), is mainly due to the role played by insulin resistance on neuronal degeneration. Mild Cognitive Impairment (MCI) also significantly increases the risk of developing AD by approxim...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Organizing healthcare delivery in the era of disease-modifying therapies for Alzheimer’s Disease: an Italian RAND/UCLA consensus

BACKGROUND: Alzheimer's disease (AD) poses a growing clinical and organizational challenge, requiring coordinated, multidisciplinary care models. In Italy, significant regional variability in resources and access to diagnostic services persists, while the implementation of commun...

Targeting food addiction through an intensive energy-reduced Mediterranean diet lifestyle intervention: evidence from the 3-year PREDIMED-plus trial

Food addiction (FA) has been proposed as a behavioural phenotype linked to obesity, potentially influencing adherence and response to lifestyle interventions. Its role within long-term, multicomponent weight-loss programmes remains unclear. This study evaluated the impact of an i...

Comparative analysis between optical see-through and video see-through technologies: usability and accuracy assessment of two head-mounted displays for cranio-maxillofacial surgery

Abstract In recent years, Mixed Reality (MR) technologies in surgery have attracted growing interest. To assess the usability and accuracy of MR in surgery, it is essential to compare the devices available on the market. However, in the literature, no studies compare optical see-...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Finite Element Analysis of Two Panthera MADs: Implications for Biomechanical Stress on Teeth and Periodontal Ligaments

Aim This study compares the biomechanical effects of 2 mandibular advancement devices (MADs), Panthera D-SAD Classic (ID1) and Panthera D-SAD X3 (ID2), on dental and periodontal structures using finite element analysis (FEA). The objective is to assess differences in stress distr...

Does Economic Policy Uncertainty Influence ESG Performance? Evidence from European Banking Sector

The purpose of this paper is to investigate the impact of economic policy uncertainty (EPU) on environmental, social and governance (ESG) performance in the European banking sector and then to investigate the moderating influence of board gender diversity (BGD) on this relationsh...

When networks sense and decide: a preliminary investigation of the human and invisible ethical dimensions of ISAC in 6G

Abstract Integrated Sensing and Communication (ISAC) is expected to become a core capability of future 6G networks, enabling wireless infrastructures to sense physical environments and human presence through shared radio resources. While offering significant technological benefit...

Phenotype-based appropriateness of IGM-enriched polyclonal immunoglobulin use in critical illness: report of an expert consensus

Sepsis and septic shock result from a dysregulated host response to infection, encompassing both hyperinflammatory and immunosuppressed phenotypes. Although immunomodulatory adjunctive therapies have been extensively investigated over the past decades, none have demonstrated cons...

TO COHABIT OR INOCULATE? TESTING THE LIMITS OF MICROBIOTA TRANSPLANTATION IN MANILA CLAMS

Abstract Microbiota transplantation has emerged as a powerful tool to investigate host-microbe interactions across a wide range of organisms, yet its applicability and ecological limits in marine bivalves remain poorly understood. Here, we experimentally test whether microbiota a...

Personalized Medicine for Rheumatic Diseases: Bridging Laboratory, Imaging, and Clinimetric Tools for Tailored Diagnosis and Treatment

The aim of launching this Special Issue was to bring together contributions on recent findings in rheumatic diseases, with a particular focus on the methodologies and tools used to detect, diagnose, and manage their clinical counterparts [...]

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

Multi-source structural identification of undocumented historic bridges via 360°photogrammetry, operational modal analysis, and model updating

This paper presents a robust, ultra-low-cost, and fully non-invasive framework for the structural identification of undocumented and hard-to-reach historic bridges under severe data-scarcity conditions. The proposed methodology combines: (i) tethered spherical (360°) photogrammet...

Exploring the potential of cluster analysis in identifying disease phenotypes in CPPD: Moving from intuition to insight

BACKGROUND: Calcium pyrophosphate deposition (CPPD) disease is a heterogeneous condition and is frequently misdiagnosed due to the different clinical presentations and variable disease progression. Aim of this study is to identify clinical phenotypes of CPPD disease by integratin...