Marche Polytechnic University

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Retrohepatic Vena Cava Encirclement, as Surrogate of Extensive Liver Manipulation During Caval Sparing Hepatectomy, Is a Risk Factor for Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma

ABSTRACT Introduction In liver transplantation (LT) with a caval sparing (CS) approach, the presence of complete encirclement of inferior vena cava (IVC‐E) by hypertrophic segment 1 increases the technical complexity of hepatectomy. Thus, in LT for hepatocellular carcinoma (HCC),...

Global trends in pleural infection mortality: a WHO-mortality database analysis

Background Current data suggest that the incidence of pleural infection is rising worldwide, however mortality data on global rates, trends and variations are lacking. Objectives To estimate pleural infection mortality rates across 24 Countries from 1994 to 2020 worldwide, using...

Knowledge design in complex domains

Traditional Knowledge Engineering (KE) often fails to address modern complex domains characterized by "wicked problems," where non-stationary ground truths and high dimensionality render static rule sets obsolete. This paper proposes a paradigm shift from traditional Knowledge En...

Multidisciplinary Delphi consensus-based recommendations on the use of image-guided radiotherapy for upper gastrointestinal tumours: an AIRO–AITRO–AIFM study

Abstract Objectives Upper gastrointestinal (GI) malignancies represent one of the most challenging scenarios for image-guided radiotherapy (IGRT). Despite technological advances, clinical practice remains heterogeneous among centres. This national, multidisciplinary Delphi consen...

The bright and dark sides of AI-driven transformation: evidence from Italian firms

Purpose This study examines how firm-level Artificial Intelligence (AI) capabilities are associated with innovation trajectories and firm performance, with particular attention to sustainability-oriented (green) and efficiency-oriented (brown) innovation outcomes. It further inve...

A Modified Delphi consensus on early management of combined cardiovascular risk factors in adult patients with type 2 diabetes in Italy

BACKGROUND: Type 2 diabetes (T2D) is a complex chronic disease often associated with other metabolic conditions that increase the risk of cardiovascular (CV) disease and early mortality. Hence, early, integrated management of T2D may prevent long-term CV complications. METHODS: T...

Operation Melilli, forensic humanitarian medico legal activities on the largest known Mediterranean disaster: the shipwreck of April 18th, 2015

On April 18th, 2015, a boat carrying about 1,000 migrants sank in the Strait of Sicily, prompting one of the most complex recovery missions ever conducted in the Mediterranean. Operation Melilli was the first time a European Government authorized the recovery of a sunken migrant...

Virtual Reality for the Assessment of Visual Capacities: A Systematic Review

Objectives: Virtual reality (VR) enables controlled, interactive, and ecologically valid visual tasks, offering potential advantages over static clinical tests. This systematic review synthesized current evidence on the use of VR technologies for assessing visual capacities acros...

Mapping Net-Zero Technologies Through Web Scraping: Evidence from Italian Corporate Websites

Abstract The Net-Zero Industry Act (NZIA) is a key initiative of the European Union aimed at accelerating the green transition and strengthening the EU’s clean-tech industrial base. However, the adoption of net-zero technologies across firms, sectors and regions remains largely u...