Mansoura National University

Dexamethasone-Induced Insulin Resistance and Hepatic Metabolic Dysfunction: Modulatory Effects of Montelukast on SGK1-Associated Signaling and NLRP3/Leukotriene-Related Responses

Background: Glucocorticoid-induced metabolic dysfunction and insulin resistance-related abnormalities are important complications associated with dexamethasone (DEX) exposure. This study investigated the protective effects of montelukast (MNT) against DEX-induced metabolic and he...

Nano curcumin as a multifunctional additive in (PVP/SA) blends: structural, optical, and antibacterial insights

Abstract Nano curcumin was incorporated into Polyvinyl pyrrolidone/ Sodium alginate (PVP/SA) blend using casting method. The decrease in amorphousity of PVP/SA polymer blend with increasing nano curcumin content was confirmed by XRD results. FTIR illustrated the coordination or i...

Deep learning-based multi-class misbehavior classification in fog-enabled vehicular ad hoc networks

Abstract Traffic collisions and congestion represent significant challenges within intelligent transportation systems (ITS). Consequently, a vehicular ad-hoc network (VANET) has been established. Numerous architectures have been incorporated into VANETs to manage the extensive da...

Metaheuristic-Based PI Controller Tuning Using a Multi-Error ITAE Objective Function for FOC-Controlled PMSM Drives in Electric Vehicle Applications

Permanent Magnet Synchronous Motors (PMSMs) are widely employed in electric vehicle (EV) propulsion systems because of their high efficiency, high power density, and superior dynamic performance. The performance of field-oriented control (FOC)-based PMSM drives strongly depends o...

Cloud-assisted IoRT framework for latency-aware analytical kinematic control of a six-DOF robotic manipulator

Abstract The Internet of Robotic Things (IoRT) has introduced new possibilities for distributed and scalable robotic control by combining industrial manipulators with cloud-based computation and networked communication infrastructures. However, the deployment of cloud-assisted ro...

Pyrazolo[3,4-b]pyridine: a privileged scaffold for the synthesis of anti-Alzheimer’s agents

Abstract Alzheimer’s disease (AD) is known to be the most prevalent neurodegenerative disorder that results in dementia and causes a variety of cognitive symptoms. There are many important aspects of AD that should be considered, even though the exact sequence of events is unclea...

Fasudil Protects Against Diclofenac-Induced Hepatorenal and Gastric Injury via Modulation of ROCK/TLR4/SIRT1 Signaling and Preservation of Tight Junctions

Background: Diclofenac is a widely consumed non-steroidal anti-inflammatory drug, yet its clinical utility is limited by severe hepatotoxicity, acute kidney injury, and gastric ulceration. While the RhoA/ROCK pathway is implicated in inflammation, its potential as a therapeutic t...