Mahidol Oxford Tropical Medicine Research Unit

Human scFv inhibiting broad coronavirus replication: a pandemic preparedness candidate

The ongoing emergence of zoonotic coronaviruses (CoVs) and the rapid evolution of viral variants underscore the need for broadly active antiviral agents. The relatively conserved S2 subunit of the coronavirus spike protein is an attractive target for developing pan-coronavirus th...

Coronavirus disease 2019 vaccination and reduced severity-related outcomes in high-risk groups in Thailand during the Omicron period

Despite the coronavirus disease 2019 (COVID-19) booster vaccination, individuals with comorbidities continue to experience disproportionately severe COVID-19 disease and adverse outcomes. Evidence on associations between vaccination status and clinical outcomes among high-risk gr...

Serum decoy receptor 3 (DcR3) concentrations and associations with clinical parameters in Plasmodium vivax and Plasmodium falciparum malaria

Decoy receptor (DcR3) is a soluble member of the tumor necrosis factor receptor superfamily with immunomodulatory properties that is elevated in several inflammatory and infectious diseases. However, its role in malaria remains poorly understood. This study investigated serum DcR...

Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay

Overview: SeptiCyte RAPID is an FDA-cleared gene expression test that quantifies host immune response to aid in the diagnosis of sepsis. The test yields a score (the SeptiScore) ranging from 0–15, distributed across four bands (1–4) based on increased likelihood of sepsis. Each b...