Maastricht University

Reframing the epidemiological transition as increasing returns to tackling aging-related diseases

Abstract Global life expectancy has risen since 1973 from 58 to over 73 years, while the share of people aged 65 years and older has doubled to 10% and is projected to reach 21% by 2073. This shift is linked to an epidemiological transition from infectious to chronic disease. Her...

Towards an Asian registry of wrongful convictions

Wrongful convictions represent a persistent yet unevenly documented problem across Asian criminal justice systems. While international research has identified common factors contributing to known wrongful convictions, systematic information about wrongful conviction cases in Asia...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

The effect of network degree on bargaining:Experimental evidence from the field

We conduct an artefactual field experiment in real-existing trade networks to analyze how individual network degree affects bargaining demands and outcomes. We combine data from a bilateral bargaining experiment with data of trade networks in 24 villages in Uganda. To identify th...

Calcium-mediated force–interval relationship drives post-extrasystolic potentiation in premature ventricular complexes: a computational study

Abstract Premature ventricular complexes (PVCs) are common cardiac arrhythmias that can lead to cardiomyopathy when frequent. Post-extrasystolic potentiation (PESP), which is the transient increase in contractility following a PVC, may serve as a predictive marker for heart failu...

Antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation: an individual patient data network meta-analysis

BACKGROUND AND AIMS: Randomized trials demonstrated that in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) direct oral anticoagulants (DOAC) and a P2Y12 inhibitor reduce bleeding compared with vitamin K antagonist (VKA) plus dual antipl...

Real‐World Medication Adherence and Medication Reviews in Adults and Children With Cystic Fibrosis

BACKGROUND: People with cystic fibrosis (pwCF) have complex treatment regimens with cystic fibrosis transmembrane conductance regulator (CFTR) modulators and supportive therapies. Evidence on adherence across cystic fibrosis (CF) therapies using different assessment methods and t...

Cardiometabolic effects of contrast therapy: A systematic review

Abstract The rising prevalence of overweight and obesity, together with associated cardiometabolic disorders, underscores the need for additional strategies alongside established interventions. The growing popularity of contrast therapy – alternating exposure to heat and cold, a...

Investigating graduates’ perception of overall goal attainment of a resilience-focused medical program offered in the United Arab Emirates: a quantitative cross-sectional study, 2025

It is vital to develop transversal skills that collectively reinforce individual learners’ resilience. Although resilience-focused initiatives are widely adopted in health and care professions’ education, these initiatives seem to take the form of discrete interventions, as oppos...

Transition from mandatory to discretionary nurse-measured MEWS assessment in a continuously monitored surgical ward: Diagnostic performance of wearable-derived early warning scores

Abstract Early detection of clinical deterioration on surgical wards is vital to prevent adverse outcomes. Conventional ward monitoring using the Modified Early Warning Score (MEWS) relies on intermittent nurse-measured vital signs, but its role may change when continuous wearabl...

A Cross-Sectional Study of Short-Video Viewing and Young Adult Health: Dose–Response Relationships with Sleep, Dream Anxiety, Ocular Surface, and Quality of Life

Background: Short-video platforms (e.g., Douyin, TikTok) have gained immense popularity among young adults, yet their addictive potential and health consequences remain understudied. Unlike gaming addiction, which has been linked to myopia and mental distress, short-video viewing...

The Challenge to Find Ideal Representation in Urban Living Labs: Lessons from the Maastricht case

Urban Living Labs (ULLs) are spaces in which ‘in situ’ experiments test the (dis)advantages and transformative potency of physical and social innovations. Unlike traditional labs, ULLs provide citizens and other stakeholders an opportunity to cocreate, try out and ‘try on’ potent...

Near-peer mentoring influences self-regulated learning strategies among medical graduates in high-stakes exams

Abstract INTRODUCTION: The Philippine Physician Licensure examinations is a high-stakes examination needed to practice medicine in the Philippines. Prior studies have indicated that performance in examinations might be influenced by student self-regulated learning (SRL) strategie...

The IO PhD International Research Program 15 years later: where do we stand?

Abstract Background International doctoral research programs represent an effective model for fostering scientific collaboration and training clinician-scientists. The Italia-Olanda PhD International Research Program (IO PhD), established in 2010, was designed to promote translat...

Crystalline/amorphous silicon and silica Bragg reflectors for gravitational wave detectors

Coating thermal noise is a major source of noise in gravitational wave detection. In order to reduce this noise, we investigate the use of silicon-on-insulator (SOI) wafers as Bragg reflectors. First, we show different architectures, such as multi-SOI as top and bottom layers, in...

Interval Scheduling Games with Color-Based Concurrent Jobs

We consider a game theoretic variant of an interval scheduling problem. Every job is associated with a length, a weight, and a color. Each player controls all the jobs of a specific color, and needs to decide on a processing interval for each of its jobs. Jobs of the same color c...

One-Pot Aqueous Assembly of Sulfimides from Thiols, Alkyl Halides, and Oxaziridines

A sequential one-pot method for the aqueous synthesis of sulfimides from thiols, alkyl halides, and an oxaziridine nitrogen-transfer reagent is reported. Thiols are first S-alkylated under aqueous conditions, and the resulting sulfides are converted directly into sulfimides witho...

Multimodal prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery

OBJECTIVES: This is a protocol for a Cochrane review (intervention). The objectives are as follows: To evaluate the benefits and harms of a multimodal prehabilitation programme versus no prehabilitation with respect to functional capacity, postoperative outcomes, and health-relat...

CREM Marks TCR-Driven T-Cell Activation and Associates with Favorable Prognosis in Papillary Thyroid Carcinoma: A Single-Cell and Bulk Transcriptomic Study

Although papillary thyroid carcinoma (PTC) is widely considered an immunologically cold tumor, detectable T-cell infiltration can influence disease progression in selected patients. Previous bulk analyses have linked cAMP-responsive element modulator (CREM) expression to a favora...

Streaming platform games: construction of the core

Abstract Streaming platforms offer subscribers unlimited access to content against a periodic subscription fee. To address the problem of dividing the revenues of the platform in a stable way among the content creators, we model these situations as cooperative streaming platform...