Maastricht University Medical Centre

Multicentre performance and consistency of two deep learning models for malignancy probability estimation of incidental pulmonary nodules

Abstract Objectives A screening-trained deep learning (DL) model (DL1) for pulmonary nodule malignancy probability estimation on CT previously demonstrated good discrimination on a single-centre dataset of incidental nodules. An updated DL model (DL2) was trained on both screenin...

Neurodevelopmental outcome in children with congenital cytomegalovirus infection: a systematic review and meta-analysis protocol

Abstract Background Congenital cytomegalovirus (cCMV) infection is the most common cause of congenital infection worldwide. Neurodevelopmental sequelae have been reported in children with cCMV across different developmental stages, from infancy to adolescence. However, the eviden...

Exploring patients’ experiences and perceptions of manipulation under anesthesia for stiffness after total knee arthroplasty: a qualitative study

Purpose To gain in-depth insight into the experiences and perceptions of patients requiring manipulation under anesthesia (MUA) for persistent stiffness after total knee arthroplasty (TKA).Material and methods A pragmatic qualitative study using the interpretive description appro...

Beating the Odds: Survival After Extracorporeal Membrane Oxygenation Decannulation Due to Poor Prognosis in Children—An Extracorporeal Life Support Organization Registry Study

Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for critically ill children. However, decisions regarding discontinuation due to poor prognosis remain ethically complex. While outcomes after successful weaning are well described, survival following decann...

Psychedelics and women’s mental health: the effects of female sex hormones on psychedelics’ efficacy and tolerability

Women experience a disproportionate burden of affective and stress-related disorders, with symptom variability shaped by endocrine transitions across the menstrual cycle, pregnancy, postpartum, and menopause. Although psychedelic-assisted therapies are increasingly investigated f...

The Burden of Small Fiber Neuropathy: Changes in Pain, Costs, and Quality of Life Before and After Diagnosis

ABSTRACT Background and Aims Small fiber neuropathy ( SFN ) is a peripheral neuropathy causing neuropathic pain, reduced quality of life ( QoL ), and high societal costs. Previous studies assessed these societal costs before a definitive diagnosis was established, leaving it uncl...