Ludovika University of Public Service

Characteristic central nervous system fingerprints and related molecular signatures in difficult-to-treat rheumatoid arthritis

Abstract Background Despite guideline-recommended treatment, approximately 30% of rheumatoid arthritis (RA) patients remain symptomatic and are classified as difficult-to-treat (D2T), representing an unmet clinical need. D2T RA is a heterogeneous state potentially involving diffe...