Loyola University Chicago

Chemogenetic inhibition of the ventrolateral orbitofrontal cortex disrupts novelty-guided updating of spatial memories and alters hippocampal engram reactivation

Abstract Rationale Adaptive behavior requires revising memories when outcomes deviate from expectations. The orbitofrontal cortex (OFC) is implicated in representing outcome expectancies, but its role in memory-updating, beyond value-based learning, remains unclear. Objectives We...

B Cell Deficiency Protects Against the Development of c‐MET and Beta‐Catenin Driven Hepatocellular Carcinoma in Mice

ABSTRACT Hepatocellular carcinoma (HCC), a lethal form of liver cancer, continues to show rising mortality rates despite advancements in immunotherapies. This highlights the need for more effective treatments. Recent studies linked the presence of B cells within human tumors, inc...

Examining Identity Development in Multiracial Students: A Scoping Review of Terminology, Research Methods, and Educational Impact

ABSTRACT The purpose of this scoping review was to map how multiracial identity development has been conceptualized, defined, and studied within educational contexts in the United States. Specifically, this review aimed to clarify what terminology is used and how those terms are...

Dose-Escalated Focal Salvage High-Dose-Rate Brachytherapy and Genomic Classifier Risk Stratification in Radiorecurrent Prostate Cancer: The F-SHARP Phase I/II Clinical Trial

Purpose Prospective data on the management of intraprostatic radiorecurrence (IPR) after definitive radiotherapy (RT) and use of genomic classifiers (GC) in this setting are limited. We hypothesized that dose-escalated focal salvage high-dose-rate brachytherapy (DE-fsHDR) would b...

Crime and Participation

Does exposure to crime mobilize or demobilize political participation? We report findings from a preregistered design, leveraging data from an original survey of 21 major U.S. cities and five waves of the Cooperative Election Study. We assess the relationships between direct vict...

From black box warning to wake-up call: menopausal hormone therapy prescribing patterns at a large academic medical center

Objective: To characterize menopausal hormone therapy (MHT) prescribing patterns over 18 years in a large academic medical center and evaluate demographic and clinical factors associated with MHT prescriptions. Methods: We conducted a retrospective observational study using elect...

Identifying incident medication‐related osteonecrosis of the jaw and antiresorptive drug holidays using natural language processing on clinical notes in men and women prescribed bisphosphonates or denosumab for fracture prevention

OBJECTIVE: Medication-related osteonecrosis of the jaw (MRONJ) is a rare complication of antiresorptive therapy for osteoporosis, with risk potentially influenced by "drug holidays" around dentoalveolar procedures. MRONJ risk is higher in rheumatic diseases. Epidemiologic studies...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

Early metabolic rewiring precedes arsenic-induced carcinogenesis in human lung epithelial cells

Chronic, low-dose inorganic arsenic (iAs) exposure is a major environmental risk factor for lung cancer, yet the early cellular events that link low-dose exposure to carcinogenesis remain poorly understood. Because most people are exposed to iAs at low, chronic doses rather than...

From just doing research to doing just research: research paradigms for emancipatory social work research

The social work profession has always prioritized working toward social justice, yet how research can accomplish that aim has been conceptualized in diverse ways. Now, problems such as the implementation gap that renders much evidence-based knowledge unavailable for high-burden c...

Food for thought: a mixed methods analysis of nutrition decision making during bedside rounds in the neonatal intensive care unit

BACKGROUND: Variation in nutrition delivery contributes to poor growth in preterm infants in the neonatal intensive care unit (NICU); however, few studies have examined how clinicians develop nutrition plans. The aim of this research is to describe the nutrition decision-making p...

Mayor Richard J. Daley and the Northern Ireland conflict, 1968–76

Abstract Between September 1969 and December 1972, Mayor Richard J. Daley of Chicago sent almost a quarter of a million dollars to charitable organisations that were helping victims of violence in Northern Ireland. He also issued scathing attacks on British and unionist governmen...

Geographic Patterns of Pancreatic Cancer Mortality and Dietary Microplastic Exposure in Italy: An Ecological Hypothesis-Generating Framework

Pancreatic cancer (PC) mortality in Italy exhibited a persistent North–South macro-geographic gradient between 2003 and 2022, with significantly higher rates in northern regions. Whilst traditional risk factors partially explain this trend, the contribution of emerging dietary xe...

A Scoping Review of Psychological Distress Outcomes in NICU Healthcare Providers

The Neonatal Intensive Care Unit (NICU) is a demanding work environment that provides medical care for acutely ill and premature infants while supporting parents experiencing significant stress and psychological distress. This scoping review is the first to examine quantitative r...

Examining Trust Among Veterans from Camp Lejeune Exposed to Environmental Toxicants: A Qualitative Study

Abstract Background Serving Veterans with military environmental exposures is a top priority of the Veterans Health Administration (VHA). This priority is critical for over 1 million Veterans and civilians who were exposed to contaminated drinking water at United States Marine Co...

The factory enters the fray: how mitochondrial protein trafficking shapes the host response to infection

Beyond textbook functions in homeostatic metabolism, mitochondria are now recognized as central coordinators of cell-intrinsic and cell-extrinsic immune responses to infection. Directed trafficking of proteins and other molecules between mitochondria and the rest of the cell unde...

Entrepreneurship and Employment: The Simultaneous Impacts of Establishment Births versus Deaths on Regional Employment across the United States

This study investigates the non-linear effects of establishment births versus deaths on regional employment, which show asymmetric pathways between intra-regional versus inter-regional spillovers. Using state-year data on establishment births, deaths, and employment for service s...

Expanded Culture Techniques Identify Uropathogens in "Contaminated" Cultures.

IMPORTANCE: Treating asymptomatic bacteriuria (ASB) during pregnancy is recommended to reduce adverse pregnancy outcomes. Some urine cultures reported as contaminated may represent clinically significant bacteriuria. Enhanced culture techniques detect more microbes than standard...

Leading Play Groups for School Children in a Caribbean School System: Reflections of Sunshine Circles Leaders

Schools use group-based interventions to efficiently provide services that promote academic and emotional well-being. Sunshine Circles is a Theraplay®-based intervention in which leaders are trained to provide playful relational, regulating activities to a classroom. This study e...

Discovery of Ro 41‐0960, a Non‐Steroidal Inhibitor of the Na + /K + ‐ATPase

The Na + /K + ‐ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure. Yet, cardiotonic steroids used in clinical practice are limited by a narrow therapeutic window and pro‐arrhythmic effects. Here, we identify Ro 41‐0960 as a non...