Linkou Chang Gung Memorial Hospital

Cross-cultural adaptation and validation of the Traditional Chinese NASA Task Load Index (NASA-TLX) for assessing perceived workload in Taiwanese adults

Background Perceived workload is central to occupational health, ergonomics, and rehabilitation research, yet no guideline-based Traditional Chinese version of the NASA Task Load Index (NASA-TLX) has been available for Taiwan and other Traditional-Chinese-speaking settings. Objec...

Reliability-aware dual-representation DCE-MRI segmentation with disagreement-guided quality control for breast tumor delineation

Automated breast tumor segmentation on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may support quantitative imaging analysis, but case-level segmentation failures remain a concern in heterogeneous multicenter data. We evaluated a reliability-aware dual-represen...

Clinical and radiological outcomes of reverse shoulder arthroplasty without preoperative 3D digital planning: a single-surgeon retrospective cohort study

This study aimed to evaluate whether reverse shoulder arthroplasty (RSA) can achieve reliable clinical and radiological outcomes when performed using standard instrumentation without preoperative 3-dimensional (3D) digital planning in patients with relatively normal anatomy. We c...

Continuous infusion of granulocyte colony-stimulating factor is associated with an advantage in neutrophil recovery in pediatric oncologic disorders

INTRODUCTION: The use of intensified chemotherapy has significantly improved overall survival (OS) and relapse-free survival (RFS) in cancer patients. However, it also increases the risk of chemotherapy-induced neutropenia (CIN). Granulocyte colony-stimulating factor (G-CSF) is c...

Three-dimensional evaluation of dental adaptation and skeletal stability following posterior open-contact surgical occlusion

Abstract This study evaluated the effects of different surgical occlusion designs, particularly posterior open contacts, on dental movement, skeletal stability, and occlusal outcomes in orthognathic surgery. A total of 49 skeletal Class III patients were classified into tripod co...

Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes.

Oral squamous cell carcinoma (OSCC) often arises from oral epithelial dysplasia (OED); however, the gene expression changes during OED progression and its microenvironment are not fully understood. This study used spatial transcriptomics to identify differentially expressed genes...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

Targeting a miRNA–mRNA regulatory network to overcome radioresistance in head and neck cancer: identification of I-OMe-AG-538 via transcriptome-guided drug repurposing

Abstract Radioresistance is a major obstacle to successful radiotherapy in head and neck cancer (HNC), leading to treatment failure, recurrence, and poor patient outcomes. MicroRNAs (miRNAs) are key post-transcriptional regulators implicated in radiosensitivity, but comprehensive...

Targeting the Gut Vascular Axis in Atherosclerosis: Probiotic and Phytoantioxidant Crosstalk as a Hypothesis-Generating Framework for Residual Cardiovascular Risk

Despite decades of effective statin therapy, a clinically important proportion of patients with atherosclerosis continue to experience ischemic events, even when low-density-lipoprotein cholesterol (LDL-C) is at guideline-recommended levels. This shortfall is increasingly attribu...

A bioactive cell sheet interface regulates scaffold–host interactions for cartilage regeneration

Abstract Cartilage tissue engineering remains challenged by uncontrolled scaffold–host interactions after implantation, particularly host tissue infiltration that can disrupt cartilage formation and compromise scaffold integrity. Although biomaterial‐based encapsulation strategie...

Epstein-Barr virus reactivation and post-transplant lymphoproliferative disease risk deserve a place in the JAK inhibitor toxicity profile. Comment on: “Janus kinase inhibitors as an evolving treatment for lymphomas and immune-mediated complications”

Not available.

Endoscopic-assisted percutaneous reconstruction of chronic Achilles tendon ruptures with allograft Achilles tendon: a report of two cases with novel surgical technique

Chronic Achilles tendon ruptures with large defects are difficult to reconstruct because of tendon retraction, poor tissue quality, and the risk of wound complications associated with open surgery. This report describes a novel endoscopic-assisted percutaneous technique for Achil...

Superior reduction quality without improved outcomes: open versus closed reduction for displaced femoral neck fractures in adults under 60 years

The optimal reduction strategy for displaced femoral neck fractures (DFNFs) in non-elderly adults remains controversial. Although open reduction may improve radiographic alignment, its impact on outcomes remains unclear. Adults aged < 60 years with DFNFs who were treated with int...

Campylobacter jejuni genotoxin promotes intestinal inflammation via the DNA damage-cGAS-STING signaling axis

The foodborne agent Campylobacter jejuni is a pervasive zoonotic pathogen and a major cause of gastrointestinal disease associated with inflammatory disorders in humans. While its genotoxin, cytolethal distending toxin (CDT), induces DNA damage, the toxicological signaling events...

Machine learning-based prediction of intraoperative desaturation risk in pediatric dental sedation using preoperative data

Dental sedation in children is widely used to reduce anxiety and facilitate successful dental procedures. However, intraoperative desaturation remains a significant safety concern. This study aimed to evaluate whether machine learning models using only readily available preoperat...

The burden of suicide by paraquat poisoning in Taiwan (1987–2017): trends, geographic variations, and demographic characteristics

Pesticide self-poisoning accounts for 14%–20% of global suicides. Paraquat, a highly lethal pesticide, is involved in a considerable number of suicides in some countries. This study investigated the burden, trends, geographic variations, and demographic characteristics of pestici...

Transcriptional analysis of co-stimulatory molecules in ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease where T-cell dysregulation plays a pivotal role. A balance of co-stimulatory and co-inhibitory molecules governs the activation of T cells. This study aimed to investigate the mRNA expression profiles of the...

Longitudinal Immunophenotypic Changes in Refractory Lupus Nephritis After B-cell Depletion: A 25-year Case Study

Background/Aim: Long-term management of systemic lupus erythematosus (SLE) requires a persistent balance between intensive immunosuppression and the prevention of opportunistic infections. This is particularly challenging in patients with a multi-decade disease history and evolvi...

Development ofa Shapley Additive Explanations (SHAP)-InterpretableModel for Cardiovascular Risk Stratification in Type 2 Diabetes Mellitus:Implications of MDA-Modified Protein Adducts and Autoantibodies

Abstract Coronary artery disease (CAD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). This study explores the two-hit oxidative–immune hypothesis by evaluating malondialdehyde (MDA)-modified protein (MDA-protein) adducts and their corresponding autoantibodi...

Smyca-FOXM1 ribonucleoprotein complex promotes homologous recombination and tumor immune evasion to define a therapeutic target of triple-negative breast cancer

BACKGROUND: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with limited treatment options. Although PARP inhibitor (PARPi) offers great promise in treating TNBC with deficiency in homologous recombination (HR), most TNBC patients are HR-profi...