Linkou Chang Gung Memorial Hospital

Development ofa Shapley Additive Explanations (SHAP)-InterpretableModel for Cardiovascular Risk Stratification in Type 2 Diabetes Mellitus:Implications of MDA-Modified Protein Adducts and Autoantibodies

Abstract Coronary artery disease (CAD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). This study explores the two-hit oxidative–immune hypothesis by evaluating malondialdehyde (MDA)-modified protein (MDA-protein) adducts and their corresponding autoantibodi...

Smyca-FOXM1 ribonucleoprotein complex promotes homologous recombination and tumor immune evasion to define a therapeutic target of triple-negative breast cancer

BACKGROUND: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with limited treatment options. Although PARP inhibitor (PARPi) offers great promise in treating TNBC with deficiency in homologous recombination (HR), most TNBC patients are HR-profi...

Same-day EHR-coded sevoflurane versus propofol exposure and long-term coded dementia in older surgical adults: a propensity-matched cohort study

Whether perioperative EHR records of sevoflurane and propofol identify clinically meaningful differences in long-term dementia risk is uncertain. We compared same-day EHR-coded sevoflurane versus propofol exposure in relation to subsequent coded dementia among older adults underg...

Interpersonal Predictors of Youth Internalizing Symptom Trajectories During the COVID‐19 Pandemic

INTRODUCTION: The COVID-19 pandemic disrupted youths' interpersonal relationships, posing risks for internalizing distress. Yet, evidence remains limited beyond the early pandemic waves and with changing interpersonal contexts. This study examined trajectories of youth internaliz...

Fracture morphology guides the selection of closed versus open reduction in straddle fractures: outcomes of an indication-based treatment strategy

To identify fracture characteristics associated with the selection of closed reduction (CR) or open reduction (OR) for anterior pelvic ring fixation in patients with straddle fractures and to evaluate the radiographic, functional, and complication outcomes following an indication...