Link Campus University

Rethinking Solid-Phase Microextraction (SPME) for Bioanalysis: Workflow Optimisation in Automated Vacuum-Assisted Cooling SPME for Fatty Acid Monitoring in Faecal Waters

Short-chain fatty acids (SCFAs) are key biomarkers of gut microbiota and intestinal health, yet their analysis is challenging due to high volatility, hydrophilicity, and the complexity of the faecal matrix. This study introduces a novel, green, and fully automated workflow for mo...

Clinical examination findings were not associated with isometric strength or functional performance in adults with groin pain

Abstract Objectives The aim of this study was to investigate whether positive clinical examination findings were associated with selected measures of lower-limb isometric strength or functional performance in physically active adults with groin pain. Methods This was a cross-sect...

Impact of GLP-1 Receptor Agonists on Cognitive Performance in Adults at Risk of Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background/Objectives: Type 2 diabetes, a widely recognized risk factor of Alzheimer’s disease (AD), is mainly due to the role played by insulin resistance on neuronal degeneration. Mild Cognitive Impairment (MCI) also significantly increases the risk of developing AD by approxim...

Conservative Management of Pediatric Mandibular Condylar Fractures: A Systematic Review

ABSTRACT Mandibular condylar fractures are common mandibular injuries in children. Conservative treatment is generally favored because of the remodeling capacity of the growing condyle, although rehabilitation protocols and the criteria for operative treatment remain variable. Th...

Large-Scale Cerebellar-Cerebral Network Alterations Underlying Impaired Social Predictive Processing in Cerebellar Neurodegeneration

Abstract The cerebellum is a key node for detecting and adjusting social-prediction internal models. Yet social prediction has been scantly investigated in neurodegenerative cerebellar patients (CB). Thus, we examined CB social-prediction abilities and related cerebellar-cerebral...

Tibial Component Malalignment in Total Ankle Arthroplasty

Background: Total ankle replacement (TAR) has emerged as a valuable alternative to ankle arthrodesis for the treatment of end-stage ankle osteoarthritis, offering pain relief while preserving joint motion and improving quality of life. Despite advances in implant design and surgi...

Radiographic accuracy of implant positioning in unicompartmental knee arthroplasty, does an imageless robotic system make a difference?

Abstract Background Robotic-assisted technologies and evolving implant designs have been introduced in unicompartmental knee arthroplasty (UKA) to improve the accuracy and reproducibility of component positioning. However, the relative contribution of robotic assistance compared...

Botulinum Toxin for Temporomandibular Disorder: Current Evidence, Clinical Applications, and Future Perspectives

Temporomandibular disorders (TMDs) are heterogeneous musculoskeletal conditions frequently characterized by pain, impaired mandibular function, and reduced quality of life. Botulinum neurotoxin type A (BoNT-A) has emerged as a potential therapeutic option, particularly for persis...

The rising burden of scabies in Italy: insights from a nationwide survey of dermatologists

BACKGROUND: Scabies is an increasingly relevant dermatological and public health issue, with rising case burdens reported in several European countries. OBJECTIVES: To assess Italian dermatologists' perceptions of recent scabies trends and current approaches to diagnosis, treatme...

Surgical treatment of complex scapular fractures: a single centre prospective observational study

Abstract Background Conservative management is traditionally preferred for scapular fractures, but recent studies suggest that surgical intervention may improve outcomes in selected patients. This study evaluates functional and imaging outcomes, complication rates, and under-repo...

Integrating urgent care centers into primary care networks to reduce emergency department overcrowding: a real-world implementation and evaluation

Emergency Department (ED) overcrowding is a major challenge for health systems and is often driven by high volumes of low-acuity visits. In 2023, the Emilia-Romagna Region in Italy implemented a network of community-based Urgent Care Centers (UCCs) to provide timely care for low-...

Future Generations' Perceptions and Evaluations of Financial Intermediaries: A Multivariate Analysis in the Digital and Sustainable Era

ABSTRACT The rapid digital transformation of financial services, increasing regulatory pressure and the growing strategic relevance of sustainability are reshaping financial intermediaries and how they are perceived by younger generations. In this context, traditional monetary co...

The Osteosarcoma Tumor Microenvironment: From Cellular Interactions to Advanced Preclinical Models

OS is the most common primary malignant bone tumor, predominantly affecting children, adolescents, and young adults. Despite advances in multimodal treatment, patient outcomes have remained largely unchanged over the past decades, particularly in cases of metastatic or recurrent...

Refined Shrimp Peptide Concentrate: Regulatory, Value Chain and Circular Blue Bioeconomy Perspectives

The European Union Regulation (EU) 2015/2283 on novel foods has created new opportunities for the valorization of marine by-products within the framework of the circular bioeconomy and sustainable blue economy. Refined shrimp peptide concentrate (RSPC), obtained through enzymatic...

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice

Abstract Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, thera...

Beyond Device Safety: Organisational Burden and Quality of Life in Oncology Outpatients with PICCs. A Descriptive Exploratory Study

Background and Objectives: Cancer care is increasingly delivered through outpatient pathways, thereby progressively transferring part of the organisational and practical workload of care to patients and informal caregivers. Although peripherally inserted central catheters (PICCs)...

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous...

Diabetic Cardiomyopathy: Distinct Clinical Entity or Manifestation of Metabolic Heart Disease?

Background/Objectives: Type 2 diabetes mellitus (T2DM) is a global epidemic strongly associated with an increased risk of heart failure, independent of coronary artery disease or hypertension. This condition, historically termed diabetic cardiomyopathy (DCM) and recently redefine...

Isolated Hypoglossal Nerve Palsy Associated with Internal Carotid Artery Dissection: A Systematic Review

Background: Isolated hypoglossal nerve palsy is a rare neurological condition with a broad differential diagnosis. Although neoplastic disorders are the most common cause, internal carotid artery dissection (ICAD) is an uncommon but clinically important and potentially reversible...

Targeting KPC-Producing Klebsiella pneumoniae Biofilms: Genomic Profiles, Clinical Outcomes and Novel Combinations

New beta-lactam/beta-lactamase inhibitor combinations (BL/BLICs) are licensed for Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) infections. However, data regarding their efficacy against bacterial biofilms and the potential of synergistic comb...