Institution
Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Recent research
- BiologyOpen access
Spectral tuning and signaling of diverse and far red–sensitive rhodopsins in mantis shrimp eyes
Stomatopod crustaceans (mantis shrimps) have extraordinary eyes with unmatched visual rhodopsin diversity, but their potential for broad color detection remains unclear. Here, we report that 17 rhodopsins, mostly from the midband eye region, are involved in color sensing and func...
- BiologyOpen access
Abstract Mitochondrial crista junctions (CJs) operate as regulated gateways into the cristae microenvironment, whose protein, metabolite, and ion compositions are finely tuned for mitochondrial function. The Mic60-Mic19 complex of the mitochondrial contact site and cristae organi...
- BiologyOpen access
Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins
Beta-arrestins (β-arrs) are cytosolic proteins which mediate G protein-coupled receptor (GPCR) desensitization, endocytosis, and signaling. Despite the widespread physiological roles of β-arr coupling, the molecular basis of GPCR/β-arr interaction has been studied primarily in mo...
- Health & MedicineOpen access
Nanobodies Equipped with HaloTag Enable Scalable Fluorescence-Lifetime Multiplexing
Abstract Fluorescence lifetime (FL) is a robust strategy for multiplexed imaging; however, variability in fluorophores’ local microenvironment when used on affinity probes broadens lifetime distributions, limiting its practical applicability. We create a modular platform for FL e...
- Materials & EnergyOpen access
Abstract Elucidating protein–protein interactions plays a crucial part in understanding disease mechanisms and advancing pharmacological research. Photocatalytic proximity labeling using antibody–catalyst conjugates enables the highly target-specific analysis of protein–protein i...
- BiologyOpen access
Pho84/GLUT2 are cellular myo-inositol exporters regulated by inositol pyrophosphates
Abstract Inositol is an essential nutrient for most living organisms, as combinatorial phosphorylation on this cyclic sugar generates key cellular messengers, such as lipid-bound phosphoinositides (PtdInsPs), water-soluble inositol phosphates (InsPs), and high-energy inositol pyr...