Lanzhou Veterinary Research Institute

Porcine Reproductive and Respiratory Syndrome Virus: Adaptive Immunity, Immune Evasion and Emerging Strategies for Disease Control

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogens affecting the global swine industry. This review summarizes current knowledge of PRRSV-induced suppression of adaptive immune responses, with particular emphasis on imp...

Contagious caprine pleuropneumonia: a review and gap analysis of its impact, epidemiology, pathogenesis, and control

Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae ( Mccp ), remains one of the most important small ruminant diseases and a major transboundary disease. Although primarily affecting goats, infections have also been reported in sheep...

Mapping of three novel linear B-cell epitopes on the VP7 protein of epizootic hemorrhagic disease virus with monoclonal antibodies

Abstract Epizootic hemorrhagic disease virus (EHDV) is an important Orbivirus transmitted by culicoides midges. EHDV poses a significant threat to ruminant production worldwide. The VP7 protein is a highly conserved, group-specific antigen of EHDV, which serves as a key target fo...

LY6E regulates Pseudorabies virus early infection via impairing viral internalization

Abstract Pseudorabies virus (PRV) causes Aujeszky’s disease, posing an emerging threat to the livestock industry and raising concern for human health. Host cells employ a wide range of intrinsic factors to combat viral infections; however, the host factors involved in restricting...

African swine fever virus pMGF110-9L plays a critical role in the integrated stress response and viral pathogenesis

African swine fever virus (ASFV) is the causative agent of ASF, a highly contagious and frequently fatal hemorrhagic disease in domestic swine and wild boars, posing a significant threat to the global pig industry. To ensure successful replication, ASFV may modulate cellular stre...

ASFV D117L hijacks KEAP1 to induce oxidative stress-dependent vascular endothelial cell death

African swine fever (ASF), caused by the ASF virus (ASFV), is a fatal hemorrhagic disease of domestic pigs that causes significant economic losses in the global pig industry. Systemic hemorrhages and abnormal coagulation of multiple tissues and organs are the typical lesions of A...