Kyushu University

Denitrative Cyanation of Nitroalkanes by Nucleophilic Substitution through Anion–Radical Coupling

Abstract We report a photocatalytic denitrative cyanation to directly convert nitroalkanes into nitriles under mild conditions. The reaction proceeds rapidly under blue LED irradiation and exhibits broad functional-group tolerance. Mechanistic investigations support an anion–radi...

Naturally Occurring ZCCHC3 Variants Modulate Antiretroviral Activity in Cynomolgus Macaques

ABSTRACT Many mammalian cells restrict viral replication by utilizing various host restriction factors. We recently demonstrated that CCHC‐type zinc‐finger‐containing protein 3 (ZCCHC3) suppresses human immunodeficiency virus type 1 (HIV‐1) replication through multiple mechanisms...

Kinetic Monte Carlo–Ising Machine Optimization for Atomistic Inverse Design of Solid Electrolytes

Abstract Maximizing ionic conductivity remains a fundamental challenge in the atomistic design of solid electrolytes. To this end, we present a framework that combines kinetic Monte Carlo (KMC) and factorization machine with quadratic-optimization annealing (FMQA), an Ising-machi...

Observation modes of EarthCARE/CPR with different Doppler measurement accuracy: evaluation of their applicability

Abstract. An accurate characterization of cloud vertical motion is essential for understanding cloud microphysical and dynamical processes. The Cloud Profiling Radar (CPR) onboard the Earth Cloud Aerosol and Radiation Explorer (EarthCARE) satellite, launched in May 2024, enables...

Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Abstract We previously reported inherited RORγT deficiency in seven patients from three ancestries (Chilean, Palestinian, Saudi Arabian) with mycobacterial disease and chronic mucocutaneous candidiasis (CMC). We report here five additional patients from different ancestries (Afgh...

On the Effectiveness of Training Data Optimization for LLM-based Code Generation: An Empirical Study

Large language models (LLMs) have achieved remarkable progress in code generation, largely driven by the availability of high-quality code datasets for effective training. To further improve data quality, numerous training data optimization techniques have been proposed; however,...

Evaluation of clinical prognostic factors for radium-223 therapy in castration-resistant prostate cancer with bone metastases: the KYUCOG-1901 study

We evaluated clinical factors associated with symptomatic skeletal events (SSEs), radiographic progression-free survival (rPFS), and overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) and bone metastases treated with radium-223 (Ra-223)...

Quantum‐Mechanical Wave Functions in Singular Potentials: Linear and Nonlinear States

ABSTRACT It is known that the attractive singular potential gives rise to the quantum collapse in the framework of the three‐dimensional (3D) linear Schrödinger equation. This article summarizes theoretical results which demonstrate suppression of the collapse caused by this sing...

From intention to adoption: integrating DOI, TAM, and TPB to design extension strategies for smallholder dairy systems

Purpose This study reviews determinants of recommended dairy farming practices (RDFP) adoption in smallholder systems, with emphasis on arid, resource-constrained regions such as Sindh, Pakistan, and examines the intention-behavior gap through DOI, TAM, and TPB.Methodology A PRIS...

Minimally invasive cardiac surgeries in 2023–annual report of the Japanese association for minimally invasive cardiac surgery

Abstract Objective To establish updated nationwide perioperative benchmarks for minimally invasive cardiac surgery (MICS) in Japan by presenting the 2023 annual report and summarizing procedural trends from 2021 to 2023. Methods Data on mitral valve (MV) surgery, aortic valve rep...

Safety of Endoscopic Ultrasound-Guided Biliary Drainage in Patients with Distal Malignant Biliary Obstruction with Large-Volume Ascites

Background/Aims: The safety and efficacy of endoscopic ultrasound-guided biliary drainage (EUS-BD) in patients with large-volume ascites (LVA) remain unclear. We aimed to evaluate the safety of EUS-BD in patients with distal malignant biliary obstruction complicated by LVA. Metho...

Biological Impacts of Microplastic Exposure in Zebrafish (Danio rerio): A Systematic Review Across Developmental, Physiological, and Neurobehavioral Endpoints

Microplastics (MPs) are emerging pollutants widespread in aquatic environments; however, their effects across the different life stages of aquatic organisms remain poorly understood. This systematic review integrates recent experimental results on the developmental, physiological...

Long-term effects of cognitive-behavioral therapy for adults with ADHD: results from an 8-year randomized controlled trial follow-up

Abstract Background To evaluate the provisional long-term durability of group cognitive behavioral therapy (CBT) benefits 8 years post-baseline and to explore tentative associations between digital booster engagement and the maintenance of treatment gains in adults with ADHD. Met...

Weathering induced microscopic and color changes in Japanese fast-growing hardwoods

Abstract Fast-growing hardwoods are increasingly used in Japan. However, their early deterioration under outdoor weathering conditions remains poorly understood. This study investigates the initial microscopic anatomical changes and surface color variations in Toona sinensis , Ch...

Experimental and CFD investigation of heat transfer in high-power avionics equipment

Reliable thermal verification of high-power-density avionics is challenging because densely packed circuit boards and narrow cooling passages complicate detailed modeling and experimental validation. This study evaluates the thermal performance of an avionics enclosure using an i...

Stringy Constraints on Modular Flavor Models

Abstract We investigate stringy constraints on moduli spaces in modular flavor models by analyzing moduli-dependent threshold corrections in heterotic string vacua. While moduli play a crucial role in determining the flavor structure of fermions predicted by modular flavor models...

“Smelltronics”—From Gas to Smell Sensing

This review discusses recent trends in smell and odor-sensing studies, including materials, devices, and interfaces. Since the invention of chemical sensors, particularly over the past few decades, gas sensor materials and devices for small molecules have been extensively investi...

Nuclear Pan‐Lysine Lactylation Immunoreactivity Is Associated With Poor Prognosis in Intrahepatic Cholangiocarcinoma

AIM: Lysine lactylation (Kla) links cellular metabolism to gene regulation, but its significance in intrahepatic cholangiocarcinoma (ICC) remains unclear. METHODS: Nuclear pan-Kla immunoreactivity was evaluated in 118 patients who underwent curative-intent resection for ICC. Asso...

Long‐Term Restoration of Anticoagulant Function After Liver Transplantation for Severe Congenital Protein C Deficiency: A Single‐Center Experience Involving Three Pediatric Patients

Severe congenital protein C (PC) deficiency is a rare inherited coagulation disorder that can be difficult to control with conventional medical treatment alone. We report a single-center case series of three pediatric patients with severe congenital PC deficiency who underwent li...

Parafermionizing the monster

A bstract We study the parafermionization of the Monster CFT with respect to its ℤ pA subgroups, with p an odd prime. Under certain assumptions, we show that the parafermionization is equal to a non-invertible gauging of $$ \mathcal{P}(p)\times \mathcal{P}{(p)}^{\vee } $$ P p × P...