KU Leuven

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Abstract Objective To assess the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) stratified by age, number of previously attempted antiseizure medications (ASMs), and SCN1A pathogenic variant status. Methods In this post hoc analysis, data from three ran...

P1.015. A Potential Option for Blown-Out Myotomy After Peroral Endoscopic Myotomy

Abstract Topic Benign Disease: Esophageal Function and Motility Case Submission A 52 year old female with an extensive medical history including left lower limb dystrophy and a complex pain problem for which she is wheelchair bound, received several neurostimulators and had a hig...

Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases

Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive over...

Characterising caregivers’ contingent responses: Short, slow, and clear speech facilitates infant turn-taking

Bidirectional temporal contingency in infant-caregiver interaction is believed to be instrumental in shaping the development of turn-taking and speech. Likewise, caregivers are known to modulate their voices in a distinctive register when speaking to infants. Yet, less is known a...

Postpartum GLP-1 receptor agonists and SGLT-2 therapies in women with prior gestational diabetes: current evidence and uncertainties

Gestational diabetes mellitus (GDM) affects approximately 14% of pregnancies and is associated with adverse pregnancy outcomes and a substantially increased risk of long-term cardiometabolic disease. Although glucose levels often normalise postpartum, women with prior GDM have a...

Single‐stage regenerative approach for persistent RT3 gingival recession following orthodontic improvement of tooth position

Abstract Background Management of gingival recession type 3 (RT3) defects remains a clinical challenge due to interproximal attachment loss and soft tissue deficiency. This case report describes a regenerative strategy for a malpositioned anterior tooth presenting with severe rec...

Leveling the Peak: Standard Waveforms for Consistent PA Benchmarking

This is a paper submitted for review that focuses on creating a set of standard signals to use in PA measurement. The paper reviews why such standard signals are needed. As a companion, we are releasing a github that has a set of signals that we have curated and will additionally...

Fluorescence-Gated Flow Cytometry Approach for Measuring Lipid Flippase Activity in Mammalian Cells

Abstract P4‑ATPase lipid flippases establish transbilayer lipid asymmetry in eukaryotic membranes, with increasing evidence indicating a role for interacting partners in regulating flippase activity. However, assessing interactor‑dependent effects on flippase activity in mammalia...

Intra-abdominal Bowel Dilation in Experimental Gastroschisis Is Associated With a Modifiable Transcriptomic Program of Intestinal Dysfunction

OBJECTIVE: To characterize intestinal transcriptional profiles in gastroschisis, their temporal evolution, and response to fetal intervention. SUMMARY BACKGROUND DATA: Gastroschisis causes significant intestinal dysfunction, with intra-abdominal bowel dilation clinically shown to...

Soil health-based business models: perspectives and policy implications

Abstract. Soil health is foundational to ecological sustainability, economic productivity, and societal wellbeing. However, fragmented perspectives on what constitutes “healthy soil” hinder coherent policies and business models. This article addresses that gap by offering a value...

ENACT FCT Maps - September 2025 - February 2026

The ENACT FCT Maps 2026 (1) summarise the trends in the observations submitted to the ENACT structured knowledge base during the period September 2025 - February 2026. The maps are aligned to the four observatories of ENACT: Capabilities Observatory Technology Observatory Market...

Intraoperative Adverse Events in Robot-assisted Minimally Invasive Esophagectomy (RAMIE)

Objective: Assess the incidence and management of intraoperative adverse events (IAEs) during robot-assisted minimally invasive esophagectomy (RAMIE) and evaluate their impact on postoperative outcomes. Background: IAEs are an inherent component of surgical practice and owing to...

ENACT FCT Maps - September 2025 - February 2026

The ENACT FCT Maps 2026 (1) summarise the trends in the observations submitted to the ENACT structured knowledge base during the period September 2025 - February 2026. The maps are aligned to the four observatories of ENACT: Capabilities Observatory Technology Observatory Market...

Warped Geometries of Segre–Veronese Manifolds

Abstract. Segre–Veronese manifolds are smooth submanifolds of tensors comprising the partially symmetric rank-1 tensors. We investigate a one-parameter family of warped geometries of Segre–Veronese manifolds which includes the standard Euclidean geometry. This parameter controls...

Putting Globus Into Context: Prevalence, Characteristics, and Overlap With Other Disorders of Gut‐Brain Interaction

OBJECTIVE: Globus is characterized by the sensation of a lump in the throat without dysphagia or underlying structural abnormality or major motility disorder. Reported prevalences vary considerably across studies. Globus has been linked to both heartburn and affective disorders....

LazyHMC: Hamiltonian Monte Carlo Simulation for Lazy, Infinite Dimensional Probabilistic Programs

Hamiltonian Monte Carlo (HMC) is a successful generic inference method in probabilistic programming, but in its ordinary formulation it needs gradients and finite-dimensional parameter spaces. In Haskell, lazy evaluation lets probabilistic programs express stochastic processes an...

In-situ visualisation of the micromechanical deformation of apple tissue using 4D X-ray computed tomography with digital volume correlation

Continuous X-ray computed tomography (XCT) combined with digital volume correlation (DVC) is presented to quantify internal three-dimensional strain and failure dynamics in apple cortex tissue during compression, revealing how the cellular microstructure governs its mechanical re...

Solution of Erdős problem # 443

In [1, p.88], Erdős and Graham posed the following problem:Let m and n be positive integers and consider the two sets {k(m−k):1≤k≤m2} and {l(n−l):1≤l≤n2}.Can one estimate the number of integers com...

Design of Stainless Steel Homogeneous and Hybrid I-Sections Exhibiting Strong Flange Behavior

Abstract Stainless steel built-up I-profile are frequently designed with webs significantly more slender than their flanges and greater material strength in the flanges in case of hybrid sections. Given the fundamental load case of pure compression or bending, the compressed flan...

Anatomy and Biomechanics of the Deltoid Ligament Complex in Healthy Ankles: Protocol for a Systematic Review and Meta‐Analysis

ABSTRACT Introduction Up to one in two individuals who have a history of an ankle injury will develop chronic ankle instability, which subsequently increases the risk of osteoarthritis development. Although lateral ankle ligament injuries are the most common, recent research show...