Korea University

Early On-Treatment Host Fitness Dynamics Refine Prognostic Stratification in Advanced NSCLC Receiving First-Line Immunotherapy

PurposeWe assessed whether baseline and early on-treatment measurements of host fitness using the Prognostic Nutritional Index (PNI) provide complementary prognostic information in advanced non-small cell lung cancer (NSCLC). Materials and MethodsWithin the prospective, multicent...

Harnessing Li‐Ion Binding Energy for Solvation‐Guided Electrolyte Additive Design and Robust Solid Electrolyte Interphase Reinforcement

The rational design of electrolyte systems is essential for stabilizing the electrode-electrolyte interface to enhance the electrochemical performance of lithium-ion batteries (LIBs). Although conventional strategies focus on the introduction of specific functional moieties, the...

Regional FireworksPollution over East and SoutheastAsia from Airborne Observations around the Spring Festival Period

Abstract Fireworks are spectacular, but they also pollute the atmosphere. While fireworks are known to rapidly increase local pollution levels, the regional influences and nanosized appearance of fireworks-related particles are poorly understood. This study collected aerosol part...

Gold‐Stabilized Copper Enables Anodic Hydrogen Evolution for Ultralow‐Voltage CO‐to‐Ethylene Electrolysis

ABSTRACT Electrochemical upgrading from CO 2 and CO to ethylene has typically been coupled with the oxygen evolution reaction (OER), whose high standard reduction potential leads to full‐cell voltages above 2.2 V at 200 mA/cm 2 . Here we explored an alternative anodic reaction, w...

Graphitic Grain‐Network Nanoarchitecture for Ultrahigh‐Rate and Exceptionally Durable Potassium Ternary Intercalation

ABSTRACT Potassium–ternary graphite intercalation compounds (K + ‐T‐GICs) are promising high‐power potassium‐ion storage materials, but their low reversible capacity and poorly understood electrolyte‐dependent behavior have limited their practical viability. Herein, this sensitiv...

Epitactic Growthduring the Fluid-Driven Aragonite-to-CalciteTransformation

Abstract Aragonite and calcite (CaCO3) are the most abundant polymorphs of calcium carbonate in the Earth’s crust and are relevant industrial minerals. The factors that control the solid-state transformation of aragonite, the high-pressure polymorph, into calcite, the stable poly...

Seeing MolecularRecognition in Action: A Visual,Amplification-Free Sandwich Assay for DNA Detection Using Noble MetalNanoparticles

Abstract This laboratory experiment introduces upper-division undergraduate and early stage graduate students to the design and implementation of a nanoparticle-based DNA sandwich assay for colorimetric DNA detection. The assay leverages sequence-specific hybridization between DN...

AI-guided De Novo design of DHPS inhibitors

Hypusine modification of eIF5A by Deoxyhypusine Synthase (DHPS) is essential for the replication of a broad range of viruses, making DHPS an attractive host-directed therapy (HDT) target for antiviral drug discovery. AI-based drug design methods spanning binding affinity predicti...

MXene as conductive mortar: Assembly of Ti3C2Tx and carbon nanotube fibers into multifunctional films for EMI shielding and infrared stealth

Advanced electronic and defense systems require multifunctional films that combine electromagnetic interference (EMI) shielding and infrared (IR) stealth with mechanical robustness, high electrical conductivity, and low IR emissivity. Here, we report a mechanically strong and hig...

Integrative Genomic Analysis Reveals Molecular and Clinical Disparities between Bladder and Upper Tract Urothelial Carcinoma in K-MASTER Program

Purpose: The clinical outcome of urothelial carcinoma presents significant variability, reflecting its molecular composition, epidemiologic attributes, and primary site of origin. Despite histological similarities, upper tract urothelial carcinoma (UTUC) and bladder urothelial ca...

Gas-assisted electrodeposition modulates the grain structure of Cu catalysts for selective conversion of CO2 to C2+ products

Electrochemical CO 2 reduction has attracted considerable research interest as a pathway to convert CO 2 into value-added multicarbon products. Cu is a key catalyst for multicarbon-product formation, and its selectivity is strongly affected by its microstructure. However, the eff...

Exclusive e-cigarette use, nicotine exposure, and early age-related macular degeneration in South Korean adults

The increasing use of electronic cigarettes (e-cigarettes) has raised concerns regarding their potential health effects, including ocular outcomes such as age-related macular degeneration (AMD). While conventional cigarette smoking is a well-established risk factor for AMD, the a...

Interspecific variation in bamboo decay capacity of bambusicolous Apiospora species

Abstract Bambusicolous fungi play crucial roles in bamboo growth, health, disease, and lignocellulose decomposition. Among them, Apiospora species occupy diverse ecological niches as endophytes, pathogens, and saprotrophs. Fungal decay ability is an important functional trait for...

2D-unsteady chaotic flows for mixing two different non-Newtonian fluids: optimization and flow control

Mixing of non-Newtonian fluids has been widely studied, yet numerical investigations of the simultaneous mixing of two different shear-thinning fluids inside chaotic mixers remain limited. In this work, we numerically investigate, for the first time, the mixing of two shear-thinn...

Development of a Low‐Starch‐Digestibility Korean Rice Snack ( Nurungji ) Substituted With Tenebrio molitor Larvae: Rheological and Sensory Enhancement

ABSTRACT Background and Objectives Starch‐based rice snacks are widely consumed but generally have low protein content and high glycemic response. This study evaluated the effects of mealworm protein forms on the rheological, nutritional, and flavor properties of a traditional Ko...

Mosapride promotes internalization of a TREK1–HTR4 complex and exerts rapid antidepressant-like effects

Major depressive disorder (MDD) remains a critical global health burden, and a substantial proportion of patients exhibit insufficient responses to conventional monoaminergic antidepressants. Selective inhibition of the two-pore domain potassium channel TREK1 has emerged as a pro...